Research team's multiscale scheme captures blood disorder's key molecular details Each year, 500,000 babies are born with a genetic disorder
called sickle cell disease, a...
Black women are more likely to have sickle cell disease, also
called sickle cell anemia.
Not exact matches
The Reverend said, however, that while he was struggling to raise the money, the hospital management
called to inform him that the
Sickle Cell Foundation of Nigeria had contributed N260, 000 to fund the operation as part of its efforts towards the treatment of the disease.
But the blood test that was used, the Sickledex test, could not tell people with the
sickle -
cell trait,
called genetic heterozygotes, apart from those with
sickle -
cell disease, the homozygotes.
Turning off a gene
called BCL11A in mice with
sickle cell (right) disease helps them to produce red blood
cells (left) with working hemoglobin molecules.
They then used the so -
called induced pluripotent stem
cells (IPS
cells) to reverse a mouse version of the genetic disorder
sickle -
cell anemia, which causes normally circular red blood
cells to form
sickle - shaped, thereby impeding blood flow.
The drug,
called SelG1, also reduced the frequency of pain crises in people with
sickle cell disease and reduced the number of days they spent in the hospital.
Kwiatkowski and his team suspect that the variation might be subject to something
called balancing selection — just like the
sickle cell variation — where genes are selected because of their ability to protect against malaria, but are kept from becoming too common because of their potential downsides.
This causes red blood
cells to become hard and sticky and resemble a curved farm tool
called a «
sickle.»
Hydroxyurea — This medication is prescribed to people with severe
sickle cell anemia and it stimulates your body to make a type of hemoglobin
called fetal hemoglobin.
Those with
sickle -
cell anemia or congenital heart defects are at greater risk for a condition
called brain ischemia or cerebral ischemia.
Anemia can be triggered by blood loss, a folic acid or vitamin B12 deficiency,
sickle cell disease, and a genetic disorder
called thalassemia, among other causes.
She
calls it «Better Days» after a group of her mother's friends who would hold parties, plays and fashion shows to raise money to fight
sickle cell anemia, a disease that runs in her family.
Tyler and her family went through great effort to
call for help, as the sick girl started to experience a
sickle cell crisis as she was exposed to the elements.