Sentences with phrase «called tyrosine kinase»

In fact, numerous animal studies show that soy isoflavones interfere with an enzyme called tyrosine kinase in the hippocampus, a brain region involved with learning and memory.

The product of the resulting BCR - ABL fusion oncogene possesses ABL's so - called tyrosine kinase activity — the ability to add phosphate chemical groups to the amino acid tyrosine — but fails to turn off appropriately.

Druker also led the original clinical development of Gleevec, which inhibits a biological switch called a tyrosine kinase that is abnormally activated in CML.

These therapies, the first an antibody and the second of a class called tyrosine kinase inhibitors (TKIs), reduce the ability of a target gene to manufacture the protein it encodes.

Drugs called tyrosine kinase inhibitors (TKIs) are generally successful at controlling the cancer.

Approximately 10 - 15 % of Caucasian and 30 - 35 % of Asian patients with NSCLC have a mutation in the epidermal growth factor receptor (EGFR), which can be successfully targeted with EGFR inhibitors called tyrosine kinase inhibitors (TKI), such as erlotinib, gefitinib and afatinib.

Not exact matches

Therefore, a team led by Vladimir Tesar, MD, PhD (Charles University and General University Hospital, in the Czech Republic) tested the potential of an investigational drug called bosutinib that inhibits a particular tyrosine kinase called Src / Bcr - Abl.

The target for ibrutinib, an enzyme called Bruton's tyrosine kinase (BTK), is a key component of B - cell receptor signaling.

These receptors, called receptor tyrosine kinases (RTKs), transmit instructions through the cell wall and down through a cascade of reactions to a target gene in the nucleus.

When PDGF arrives at the cell surface, it binds to a protein called PDGF receptor tyrosine kinase (PDGF RTK).

It inhibits two tyrosine kinase enzymes called Jak1 and Jak2, which rev up production of immune cells.

In 2005, Cagan's team created a general fly model of a human thyroid tumor caused by mutations in the Ret receptor tyrosine kinase gene, then screened a panel of drugs including a kinase inhibitor called vandetanib that suppressed the tumor (Cancer Res, 65:3538 - 41, 2005).

According to Vogelstein, genetic mutations can produce a tyrosine kinase that is essentially «turned on» in the absence of a normal activation signal, which is called constitutive activation.