Not exact matches
However, in the presentations, speakers for both teams said that two stretches of the gene code for so -
called zinc fingers —
protein structures that insert themselves into the grooves of DNA — suggesting that the encoded
protein probably turns other genes on and off.
Talk of curing AIDS made front - page news last year, in part due to an astonishing new gene - editing technology: lab - engineered
proteins called zinc finger nucleases.
Its competitors — designer
proteins called zinc finger nucleases and TALENs — also precisely alter chosen DNA sequences, and several companies are already exploiting them for therapeutic purposes in clinical trials.
These gene - regulating
proteins have an important feature
called a
zinc finger domain.
In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes
call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface
protein that HIV latches onto in order to infect cells.
Last year, researchers targeted and destroyed this gene in the T - cells of 12 people with HIV using custom - made
proteins called zinc finger nucleases.
When
zinc hooks up with a gene - controlling
protein, it forms «
zinc finger proteins» - so
called because they can poke into the tight groove between the two strands of DNA and touch the sequence they're made for.
Working with
proteins called zinc finger nucleases and TALENs, Zhang attempted to edit the genomes of mammalian cells with a view to engineering them.