Sentences with phrase «calmodulin dependent»

Both DAG and calcium are essential second messengers which activate downstream signaling components such as protein kinase C and calmodulin dependent kinase.

Not exact matches

Cunningham and her postdoc at the time, Christine Kirvan, found that the antibodies literally bind to human neurons, activating an enzyme called calcium / calmodulin - dependent protein (CaM) kinase II.

Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH -(reduced form of nicotinamide adenine dinucleotide phosphate), Ca2 + / calmodulin - dependent type I NO synthase of about 150 kilodaltons.

When calcium floods a neuron as a memory is formed, it turns on an enzyme called CaMKII (calcium / calmodulin - dependent protein kinase).

However, once opiate addiction had developed, the scientists observed a functional switch to a separate molecular memory pathway, controlled by a molecule called calmodulin - dependent kinase II or «CaMKII.»

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

Now, Dong et al. have investigated the consequences of Dab2 downregulation in a new STEM CELLS Translational Medicine study, demonstrating a novel role for calcium / calmodulin - dependent protein kinase kinase - 1 (CAMKK1) in the modulation of MSC secreted factors and a potential exciting means to enhance MSC - based cardiac repair [2].

Inactivation of the myocyte enhancer factor - 2 repressor histone deacetylase - 5 by endogenous ca2 / / calmodulin - dependent kinase ii promotes depolarization - mediated cerebellar granule neuron survival.

Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin - dependent protein kinase II (CaMKII) binding to the N - methyl - D - aspartate (NMDA) receptor subunit GluN2B.

Molecular interaction and functional regulation of ClC - 3 by Ca2 + / calmodulin - dependent protein kinase II (CaMKII) in human malignant glioma.

NSP2 functions downstream of Nod - factor - induced calcium spiking and a calcium / calmodulin - dependent protein kinase.

Abbreviations: AMPAR, AMPA receptor; AS, Angelman syndrome; BDNF, brain - derived neurotrophic factor; CaMKII, α - calcium / calmodulin - dependent protein kinase II; CGN, cerebellar granule neuron; co-IP, coimmunoprecipitation; DG, dentate gyrus; ERK, extracellular signal - regulated kinase; fEPSP, field excitatory postsynaptic potential; Gab1, Grb2 - associated binder 1; HFS, high frequency stimulation; IGF, insulin - like growth factor; LTP, long - term potentiation; PSD - 95, postsynaptic density protein - 95; SYN, synaptophysin; WT, wild type

RESULTS: Anthocyanin Cy -3-g increased cellular AMPK activity in a calmodulin kinase kinase dependent manner.

We also CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca 2 + / calmodulin - dependent protein kinases on the Serine 133