I don't think this negates Dr. Greger's points / conclusions in this video but I have noticed that he asserts that «the benefits of
caloric restriction on health and aging has been clearly demonstrated» (i'm assuming he means in humans) in several videos and blog posts including today's (15June 2015) post «Living Longer by Reducing Leucine Intake».
It has been hypothesized that the reported beneficial health effects from
caloric restriction on excess body weight, cardiovascular risk factors, glucose metabolism, tumor physiology, neurodegenerative pathology and life span can be mimicked by alternating periods of short term fasting with periods of refeeding, without deliberately altering the total caloric intake.
The Rosedale Diet is the most scientifically advanced diet in the world, that has been shown to mimic the amazing effects of
caloric restriction on health and life extension, without having to even think about restricting calories.
This prompted keen scientific interest on the effects of
caloric restriction on lifespan.
Transgenerational effects of
caloric restriction on longevity, B - vitamins silencing bad genes, cognitive stimulation revering neurodegenerative disease, exercise increases neurogenesis, and vitamin D controls aging.
Effect of acute
caloric restriction on work efficiency.
Beneficial effects of intermittent fasting and
caloric restriction on the cardiovascular and cerebrovascular systems
Not exact matches
Some of the medical studies I used as a reference are:
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging and Dietary Factors, Hormesis and Health, found
on the US National Library of Medicine Site, Cardioprotection by Intermittent Fasting in Rats
on the American Heart Association Site and Effect of Ramadan intermittent fasting
on aerobic and anaerobic performance and perception of fatigue in male elite judo athletes from the Journal of Strength and conditioning research.
«If
caloric restriction does not extend human lifespan, we're an exception
on the planet,» says gerontologist David Sinclair of Harvard University.
«You can't put human [study subjects]
on caloric restrictions all their lives,» he says, but adds: «There is no reason why it couldn't apply to humans.»
Live fast, die young, might also explain the age - defying effects of
caloric restriction, assuming that the metabolism of an animal
on a starvation diet becomes more efficient, so producing fewer free radicals.
Some people have put themselves
on caloric -
restriction regimes (SN: 10/25/08, p. 17).
An influential 2012 report
on 120 monkeys being studied at the National Institute of Aging (NIA) reported no differences in survival for
caloric restriction animals and a trend toward improved health that did not reach statistical significance.
«We study
caloric restriction because it has such a robust effect
on aging and the incidence and timing of age related disease,» says corresponding author Rozalyn Anderson, an assistant professor of geriatrics.
The rationale for using it came from research
on caloric restriction, the world - champion method for making animals live longer.
The results imply there is likely some olfactory component affecting humans
on caloric restriction diets as well.
Pletcher's group exposed two lab strains of fruit flies
on caloric restriction to smells created by live yeast, an important constituent of the fly's diet.
«I'd been working
on caloric restriction in animals for 20 years,» he says.
The primary method of achieving weight loss was
caloric intake
restrictions, based
on guidelines from the American Diabetes Association.
The most recognized common strategy has been focused
on caloric restriction (CR) defined as a dietary regimen low in calories without malnutrition.
«These conflicting outcomes had cast a shadow of doubt
on the translatability of the
caloric -
restriction paradigm as a means to understand aging and what creates age - related disease vulnerability,» says Anderson, one of the report's corresponding authors.
The current findings are «another piece of evidence that what we see in laboratory rodents
on caloric restriction translates to humans,» said Richard Weindruch, PhD, of the University of Wisconsin — Madison, who has studied
caloric restriction since 1975 but did not participate in Floel's study.
Researchers who study
caloric restriction have two main theories
on how it might slow aging.
«The results seem pretty dramatic,» says Mark P. Mattson, PhD, a senior investigator at the National Institute
on Aging in Bethesda, Md. «Even though the number of subjects in the study was not really high, they had really high, statistically significant improvements in their performance
on the memory test,» added Mattson, who studies
caloric restriction and the brain in his role as chief of the Cellular and Molecular Neurosciences Section at the Laboratory of Neurosciences but was not involved in Dr. Floel's investigation.
These «diets» rely
on absolute
caloric restriction to elicit temporary fat loss not some special characteristic of the «gimmick food».
Human studies back this up too showing that when human subjects fasted
on alternate days they not only showed the same benefits as
caloric restriction groups, but also showed an increased ability to lose weight and improvements in coronary heart disease risk factors.
Ketosis, similarly to fasting or
caloric restriction, turns
on a group of genes called Sirtuins.
Willcox, BJ et al 2007
Caloric Restriction, the Traditional Okinawan Diet, and Healthy Aging The Diet of the World's Longest - Lived People and Its Potential Impact
on Morbidity and Life Span.
In most long - term studies, the effect of increased protein consumption
on appetite was obscured by
caloric restriction imposed
on subjects in addition to the altered macronutrient content of the diet (26 — 29).
In summary, if one is
on a plant based diet, they can mimic the levels of DHEA found in
caloric restriction without going around hungry, thereby significantly increasing lifespan.
In 2005, in the Annals of Internal Medicine, the article «Effect of a Low - Carbohydrate Diet
on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes» showed that 2 weeks of a very low carbohydrate diet with no
caloric restrictions reduced appetite and body weight.
Apfelbaum M, Bostsarron J, Lacatis D. Effects of
caloric restriction and excessive
caloric intake
on energy expenditure.
Weight is regained despite dietary compliance with the
caloric restriction and even as your friends and family silently accuse you of cheating
on your diet.
The latest salvo in Macro-Nutrient Land is the Calorie
Restriction Diet, inspired by animal experiments in which mice, guppies, water fleas, yeast, spiders, Labrador retrievers, a microscopic water invertebrate called the rotifer, and rhesus monkeys are said to live longer
on diets that restrict
caloric intake.13 Researchers are encouraged by the longevity of a single monkey who has reached 38 years
on a diet in which the portion of monkey chow — dried compressed pellets of wheat, corn, soybean, alfalfa, fish and brewer's yeast — has been cut by 30 percent compared to controls.
Are you
on caloric restriction?
VIDEO — Dr. Guido Kroemer
on Autophagy,
Caloric Restriction Mimetics, Fasting & Protein Acetylation
The composition of the diet in both regimens followed the Study Group
on Diabetes and Nutrition of the European Association for the Study of Diabetes guidelines [15] with the same
caloric restriction: a
restriction of 2,092 kJ / day (500 kcal / day) based
on the measurement of each individual's resting energy expenditure (REE) by indirect calorimetry (metabolic monitor VMAX; SensorMedics, Anaheim, CA, USA)[16].
i said and decided to go back to birth control pills, i was really tired of spending lots of money at this private clinic (i'm from Russia, health insurance doesn't cover it, blood tests are very expensive) so i was
on birth control for about 1,5 years and didn't care much about it all, i was working out, eating about 100 - 150 carbs a day, very low fat, and always in
caloric restriction, 1300kkal maybe..
The stresses
on the body, the epigenetic genes that are — are expressed by reducing uh —
caloric restriction.
Studies
on calorie
restriction through short - term fasting just before chemotherapy — defined as a complete lack of food and
caloric beverages (noncaloric beverages such as water are allowed) for 72 hours or less — has demonstrated a wide range of beneficial effects.
By focusing solely
on calories and
caloric restriction (Caloric Restriction as Primary), we ignore the fact that weight loss in this method will result in the body desperately trying to bring the weight back up to its original
caloric restriction (Caloric Restriction as Primary), we ignore the fact that weight loss in this method will result in the body desperately trying to bring the weight back up to its origi
restriction (
Caloric Restriction as Primary), we ignore the fact that weight loss in this method will result in the body desperately trying to bring the weight back up to its original
Caloric Restriction as Primary), we ignore the fact that weight loss in this method will result in the body desperately trying to bring the weight back up to its origi
Restriction as Primary), we ignore the fact that weight loss in this method will result in the body desperately trying to bring the weight back up to its original weight.
Check out these videos for more
on the link between meat consumption and cancer: Uprooting the Leading Causes of Death
Caloric Restriction vs. Plant - Based Diets Carnitine, Choline, Cancer, and Cholesterol: The TMAO Connection
Spaeth AM; Dinges DF; Goel N. Effects of experimental sleep
restriction on weight gain,
caloric intake, and meal timing in healthy adults.
Note also that the reduction in leptin may be primary to elicit the metabolic adaptations of
caloric restriction, including the reduction in thyroid / free T3, and therefore the extreme beneficial effects
on health and lifespan.
Very low carbohydrates such as mine has similar effects
on thyroid as
caloric restriction.
«This retrospective analysis of patients from a private clinic adhering to a high - fat, low carbohydrate, adequate protein diet [the Rosedale diet] demonstrated reductions in critical metabolic mediators including insulin, leptin, glucose, triglycerides, and free T3... Patients in this study demonstrated a similar directional impact
on the measured parameters when compared to studies using more established models of longevity such as
caloric restriction.»
Much of the research included here comes from studies
on caloric restriction and intermittent fasting.
The elements of the ketogenic diet are thoroughly explained with helpful tables of foods with their
caloric and nutrient content, as well as practical direction regarding foods to focus
on — healthy fats, quality protein and calorie
restriction.
Caloric restriction has also been shown to have an effect
on thyroid hormones, specifically T3.
However, the recently published systematic review by Helms et al. [33]
on protein intakes in resistance - trained, lean athletes during
caloric restriction suggests a range of 2.3 - 3.1 g / kg of LBM, which may be more appropriate for bodybuilding.