In addition, average levels of
fecal calprotectin decreased from 471 at week 1 to 112 at week 11 (1).
By running labs we can rule out underlying gut problems like leaky gut syndrome and inflammatory gut proteins, such
as calprotectin.
Dr. Justin Marchegiani: Yeah, it's nice to be able to quantify because if we see CRP above 1, or fibrinogen above 300 or homocysteine above 8 or 9 or we see, let's say
increasing calprotectin or lactoferrin or various lysozymes or you know, IgA is very, very high and this is some of the gut inflammation markers.
Fecal calprotectin in predicting relapse of inflammatory bowel diseases: a meta - analysis of prospective studies.
Levels of gut microbial diversity, faecal
calprotectin (a marker of gut inflammation) and E coli colonisation were also examined.
β - Glucans in food modify colonic microflora by inducing antimicrobial protein,
calprotectin, in a Dectin -1-induced-IL-17F-dependent manner — T Kamiya — Mucosal Immunology
Calprotectin is a protein found in white blood cells called neutrophils that make up three - quarters of your white blood cell counts.
Some stool testing labs use
calprotectin as their inflammatory marker, and some experts consider calprotectin to be the gold standard measurement of intestinal inflammation.
The main diseases that cause an increased excretion of fecal
calprotectin are Crohn's disease, ulcerative colitis and neoplasms such as bowel cancer.
An elevated SIgA along with an elevated lysozyme,
calprotectin or lactoferrin level will tell you that there is inflammatory bowel disease (Crohn's disease or ulcerative colitis), an elevated SIgA with low or normal lysozyme, calprotectin or lactoferrin levels will tell you that there is either IBS (irritable bowel syndrome) or a significant food allergy or infection.
Levels of fecal
calprotectin and lysozyme will be found to be normal in patients with irritable bowel syndrome (IBS).
Although a relatively new stool test, fecal
calprotectin is regularly used as indicator for inflammatory bowel disease IBD during treatment and as diagnostic marker.
An elevation of lysozyme or
calprotectin (biomarkers of inflammation, some labs may use one or the other marker) is an indication of intestinal inflammation, and it may be an indication of inflammatory bowel disease (ulcerative colitis or Crohn's disease), but may be found in celiac patients as well.
Calprotectin is a marker of intestinal inflammation that is predictive of relapse in quiescent IBD patients when it appears at higher levels (59, 60).
Parameters of antioxidant defense and oxidative damage, myeloperoxidase, several cytokines, fecal
calprotectin and CRP were determined.