Sentences with word «camptothecin»

«While FL118 is an analogue of irinotecan and topotecan, two FDA - approved cancer drugs that are also based on the naturally occurring compound camptothecin, our findings add further evidence that FL118 has novel mechanisms of action that may make it especially potent against solid tumors and especially effective as a well - tolerated, targeted therapy,» said Dr. Li, an Associate Professor of Oncology in the Department of Pharmacology and Therapeutics.

Tests on laboratory animals with a type of experimental leukemia... have shown that the extract, known as camptothecin, has high antitumor properties.

Although it didn't prove effective against leukemia, a synthetic version of camptothecin is used to treat ovarian, lung and

While thousands of agents based on camptothecin have been synthesized, and two of these analogs — irinotecan and topotecan — have been approved for treatment of many solid - tumor cancers, these compounds typically are highly toxic to healthy cells, and not all of them have proven effective as anticancer agents.

In vitro research revealed that curcumin decreased camptothecin - induced death of cultured breast cancer cells.

ATM - dependent activation of p53 is usually induced by many — if not all — types of DNA - damage drugs, including camptothecin compounds such as irinotecan and topotecan, leading the authors to conclude that FL118's mechanisms of action are distinct among camptothecin analogues.

The small molecule is structurally similar to camptothecin, a component in the bark and stem of a tree native to China that has long been a traditional Chinese remedy for cancer.

MIT's new nanoparticle carries three cancer - fighting drug molecules — doxorubicin is red, the small green particles are camptothecin, and the larger green core contains cisplatin (Image: Jeremiah Johnson)

When the nanoparticle encounters a cellular enzyme called esterases it releases the second drug, camptothecin.

The team has tested its triple threat nanoparticles, containing drugs typically used to treat ovarian cancer (such as doxorubicin, cisplatin and camptothecin), against lab - grown ovarian cancer cells.

The mechanism of topoisomerase I poisoning by a camptothecin analog Proceedings of the National Academy of Sciences (Vol.