Sentences with phrase «cancer blood vessel cells»

It may even be possible to modify the cancer blood vessel cells to secrete factors that would inhibit cancer cell growth.

Not exact matches

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

For over one hundred years, scientists have debated the question of the origins of the lymphatic system — a parallel system to the blood vessels that serves as a conduit for everything from immune cells to fat molecules to cancer cells.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Opioids also may make blood vessels leaky, making tissues more receptive to cancer cells looking for places to build a tumor, Moss says.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

Fat cells cultured from the body mass index of a morbidly obese patient cause multiple myeloma cells to anchor to a much greater extent than normal cells and produce a significantly larger number of blood vessels to sustain the cancer cells.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

The cancer cells spread from one place in the body to another, through the blood vessel.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

As a result, these blood vessels will be structured more tightly, which can prevent cancer cells from spreading to other organs.

In other words, the same «old» medicine simultaneously targets the cancer cells themselves and the blood vessels with great efficiency.

When BRCA1 is mutated, ANG1 switches on, new blood vessels are formed, and cancer cells get the nutrients critical to their survival.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

They found that besides traveling in the bloodstream, melanoma cells could also move along the abluminal, or outside, surface of blood vessels by way of angiotropism, a biological interaction between the cancer cells and the blood vessel cells.

With angiotropism and EVMM, the cancer cells may replace a type of cell called a pericyte, which normally resides on the outsides of blood vessels.

Based on the pioneering work of Dr. Claire Lugassy and Dr. Raymond Barnhill at UCLA's Jonsson Comprehensive Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) light.

A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.

«UV light accelerates cancer cells that creep along outside of blood vessels.»

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

Aifantis, the chair of the Department of Pathology at NYU Langone and a member of its Perlmutter Cancer Center, and an early career scientist at the Howard Hughes Medical Institute, says experiments in his laboratory had shown that leukemia - initiating cells concentrate in the bone marrow near CXCL12 - producing blood vessels.

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature — the small blood vessels that transport blood within tissues — as a niche where dormant cancer cells reside.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

This neural highway might be especially important in pancreatic cancer, they say, because it grows fewer blood vessels that can carry cancer cells to the rest of the body.

The experimental drug cediranib blocks the cell surface receptor VEGF, which stimulates the growth of new blood vessels to feed the growth of tumours,» explains study researcher Dr Paul Symonds, of the Department Cancer Studies & Molecular Medicine at the University of Leicester, UK.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

Researchers from the University of Portsmouth's Brain Tumour Research Centre of Excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain.

They also used a model which simulated the cancer cells flowing through the blood vessels, and got the same result.

«Loophole for cancer cells found: Cancer cells kill blood vessel cells so that they can slip through the vascular wall, form metastases.&cancer cells found: Cancer cells kill blood vessel cells so that they can slip through the vascular wall, form metastases.&Cancer cells kill blood vessel cells so that they can slip through the vascular wall, form metastases.»

These cells have different factors on their surfaces which determines how «sticky» the cells are and whether they are responsible for mediating the cancer cells binding to the blood vessel walls.

One drug attacks cancer cells; the other inhibits cancer cell formation and the growth of blood vessels at tumor sites.

Cancer cells and tumors at first rely on nearby blood vessels to get what they need to survive, but, as tumors grow, they need to form new vessels.

Dr Kat Arney, Cancer Research UK's science communications manager, said: «This exciting research may have cracked how healthy cells in the blood vessels are protecting against cancer treatCancer Research UK's science communications manager, said: «This exciting research may have cracked how healthy cells in the blood vessels are protecting against cancer treatcancer treatments.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

Lymphovascular invasion (LVI) means that malignant cancer cells «invade» the blood vessels and lymphatic system, from whence they can be transported onwards.

Dr. Nagy is renowned for his work in stem cells, blood vessel biology, and creating genetic tools in cancer cells, among other areas.

The team's experiments in cell cultures, conducted with funding from an American Brain Tumor Association Discovery Grant, showed that coibamide A cuts off the cancer cells» ability to communicate with blood vessels and other cells, eventually starving the cell and triggering its death.

Due to the lack of oxygen in the cancer cells, VEGF - A (Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.

In another, a cancer cell trails sticky appendages as it rolls through a blood vessel and attempts to gain purchase on the vessel wall.

According to a new study, these «cancer stem cells» reside in blood vessels.

The dendrimer, an extremely tiny nanoparticle, takes advantage of certain physical characteristics that blood vessels leading to cancer cells have, but healthy ones do not.

«Scientists discover how breast cancer cells spread from blood vessels.»

This study sheds light on how cancer cells leave the blood vessels to travel to a new part of the body, using a technique that allows researchers to map how cancer cells interact and exchange information with cells that make up the blood vessels.

Researchers at Emory University School of Medicine were testing whether GM - CSF (granulocyte - macrophage colony stimulating factor), already used to restore white blood cell numbers during cancer treatment, could help heal blood vessels damaged by atherosclerosis.

Dr Claus Jorgensen, who led the research at The Institute of Cancer Research, London, and at Cancer Research UK's Manchester Institute at the University of Manchester, said: «The next step is to figure out how to keep this receptor switched on, so that the tumour cells can't leave the blood vessels — stopping breast cancer spreading and making the disease easier to treat successfully.&Cancer Research, London, and at Cancer Research UK's Manchester Institute at the University of Manchester, said: «The next step is to figure out how to keep this receptor switched on, so that the tumour cells can't leave the blood vessels — stopping breast cancer spreading and making the disease easier to treat successfully.&Cancer Research UK's Manchester Institute at the University of Manchester, said: «The next step is to figure out how to keep this receptor switched on, so that the tumour cells can't leave the blood vessels — stopping breast cancer spreading and making the disease easier to treat successfully.&cancer spreading and making the disease easier to treat successfully.»

When cancer cells interact with the walls of the blood vessels, EPHA2 is activated and the tumour cells remain inside the blood vessels.