Sentences with phrase «cancer cell adhesion»

In a primary screen, the researchers identified 17 compounds that inhibited cancer cell adhesion and invasion by at least 75 percent.

Not exact matches

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

The groundbreaking study identified a protein, known as cadherin - 22, as a potential factor in cancer metastasis, or spread, and showed that hindering it decreased the adhesion and invasion rate of breast and brain cancer cells by up to 90 per cent.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

The team at Barts Cancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaginCancer Institute, part of Queen Mary University of London, have found that a molecule, called focal adhesion kinase (FAK), signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damagincancer cells by damaging DNA.

In the case of cancer, ineffective cell adhesion allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

This work outlines how a receptor termed LFA - 1 on the surface of T - cells mediates adhesion to other cells such as cancer cells.

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF - 7 human breast cancer cells.

The role of tyrosine phosphorylated caveolin - 1 in regulating focal adhesion dynamics and cancer cell migration.

Functional expression of CXCR4 (CD184) on small - cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

«Many cancer stem cells overexpress this surface adhesion molecule.

MAP3K8 controls cancer cell proliferation and migration by regulating key players in G1 / S transition and adhesion dynamics.

Cancer cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions.

Our final review article, from the labs of Maximilian Boesch (Kantonsspital St. Gallen, Switzerland) and Andreas Seeber (Medical University of Innsbruck, Austria), provides an update on the role of epithelial cell adhesion molecule (EpCAM) in cancer stem cells (CSCs) and the epithelial ‐ to ‐ mesenchymal transition (EMT) in colorectal cancer (CRC).

Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.

Their three - dimensional cell - culture system, adapted for high - throughput screening, has enabled them to identify small molecules that can inhibit adhesion and invasion, preventing ovarian cancers from spreading to nearby tissues.

The company's antibody - based product candidates target a number of potential indications including AL and AA forms of amyloidosis, Parkinson's disease and other related synucleinopathies and novel cell adhesion targets involved in inflammatory diseases and cancers.