Sentences with phrase «cancer cell behavior»

Marcus stresses that SaGA can be applied to additional cell types or environments, or other types of cancer cell behavior such as drug resistance.

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behavior.

Not exact matches

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

In cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstream.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

«If cancer recurs, it may be because the therapy didn't hit key mature cells that take on stem cell - like behavior.

Dr. Massagué is particularly interested in the ability of tumor cells to hug blood vessels, as he suspects this behavior may be essential for the survival of metastatic cancer cells not only in the brain but also in other parts of the body where metastatic tumor growth can occur.

«Our data clearly suggests that AKR1B1 overexpression represents an oncogenic event that is responsible for the aggressive behaviors of basal - like breast cancer cells,» Dong explains.

Scientists now know that what matters most in determining the behavior of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant cell growth instead of where the tumor begins in the body.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually called on — and whether normal epithelial cells begin to exhibit the behaviors characteristic of highly malignant cancer cells.

While it has been well - established that people should avoid behaviors like smoking to decrease cancer risk, it is less well - known that each time a normal cell divides and copies its DNA to produce two new cells, it makes multiple mistakes.

It likely works to prevent cancer by enhancing MAP1S - activated autophagy, or the cells» self - eating behavior: The benefits of spermidine disappear when MAP1S isn't available.

This insight into cell behavior could help researchers better understand cell jamming and unjamming, which could lead to potential treatments for conditions such as developmental abnormalities, asthma, and cancer.

This adaptive behavior, Emerson speculates, lets the group of cancer cells prepare for the next unanticipated threat.

Only by understanding the behavior of normal cells, she maintained, would scientists learn how to prevent abnormal behaviors, such as cancer.

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

Before long, the cancer cell is abnormal enough that it takes on behaviors that eventually kill us.

When mutations do arise and cancer ensues, traditional chemotherapies have taken advantage of the universally - dividing behavior of cancer cells, attacking the cellular machinery necessary for division.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

The team went on to test how sarcosine affected the behavior of cancer cells grown in the laboratory.

Manning believes that cell jamming likely provides an overarching mechanical explanation for many of the cell behaviors involved in cancer, including extrusion.

Using a branch of mathematics called information theory, Califano's team, along with Mariano Alvarez, PhD — DarwinHealth's Chief Scientific Officer — developed algorithms that can identify these critical proteins — dubbed «master regulators» — that hold the key to the malignant behavior of cancer cells.

To a small but growing number of physicists, however, the shape - shifting and behavior changes in cancer cells evoke not an errant genetic program but a phase transition.

Many scientists now believe that — complementing its initial focus on mutated genes — precision oncology must now also address the activity of otherwise normal proteins and molecular pathways that are ultimately responsible for cancer cells» malignant behavior.

Meanwhile, Josef Käs, a physicist at Leipzig University in Germany, wondered if jamming could help explain puzzling behavior in cancer cells.

JAX has particular strengths in research focused on understanding aging, behavior and addiction, computational biology, cancer, development and disease, gene expression, genetics and genomics, immunology and hematology, metabolism, microbiome, neuroscience, reproductive biology, statistical and population genetics, stem cells, systems biology, and translational medicine.

A methodology to investigate the relationship between cancer cells cell - cycle phase and their migratory behaviors

Studies show that human cancer cells express high levels of the fatty acid synthase enzyme, which is associated with aggressive tumor behavior and tumor - cell growth.

It decreases cell invasion, metastasis and epigenetic behavior of cancer cells as well.

Biopsy provides a complete picture of tumor type and behavior and allows us to determine if the surgical margins are clear of cancer cells.

Looking at the size, shape, and behavior of cells under a microscope helps to tell whether a cancer is benign or malignant.