Sentences with phrase «cancer cell clones»

conduct computational meta - analyses on large, aggregated cancer genome data sets to identify the long tail of infrequently mutated cancer genes, to characterise mutational signatures and to inform on the evolution of cancer cell clones.

Not exact matches

The new technique used software to assign the cancer cell with the fewest mutations as the ancestral clone and place it at the root of the evolutionary family tree, with the other clones arranged as branches above it.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

Monoclonal antibodies are generated by clones of a type of white blood cell that have been fused to myeloma (cancer) cells to form fast - growing «hybridomas.»

«In this study, we showed that cancer stem cells co-opt a RNA editing system to clone themselves.

With so much work needed in studying the nature of stem cells and using them to study disease processes, therapies based on ES cells seem very far down the line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.

CHICAGO, Ill. — The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

We have shown that p53 and Notch inhibiting mutations, both of which are common in squamous cancers, imbalance cell fate in this way, generating large mutant clones.

He and his colleagues were the first to demonstrate that human antigen - specific T cell clones could be isolated and expanded in vitro and then re-infused into patients to prevent or treat viral infections and to mediate therapeutic responses in patients with cancer.

Her blood cells should be dominated by the clone of the most effective cancer genome.

Similar to primary keratinocytes, long - term — cultured squamous cell carcinoma (30) and many other epithelial cancer cells (30, 31) can also form different types of clones in culture.

Background: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood - cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer.

These results reveal that prostate cancer cells are heterogeneous in establishing different types of clones.

Cancer researcher Carlo Croce, M.D., who worked at Wistar from 1970 to 1988 and held the position of associate director from 1980 to 1988, cloned and characterized the B - Cell lymphoma (BCL2) gene in 1985, defining its role in various lymphomas.

S1B) prostate cancer cells were cultured at clonal densities, in ∼ 2 weeks clones resembling keratinocyte holoclones, meroclones, and paraclones could be easily identified.

Like keratinocyte clones (2 — 4), prostate cancer cell holoclones consisted of tightly packed, small cells and paraclones of larger and fewer cells, whereas the meroclones were made of cells of intermediate sizes and numbers (Supplementary Fig.

The progression of the ancestral tumor cell to a full - blown cancer results from the sequential acquisition of additional mutations that confer a selective growth advantage to the original clone.

Interview talks with romance - novel - cover ready fantasy man, the Outlander star Sam Heughan Playbill George C Wolfe and Oprah Winfrey are working on a cool sounding project called The Immortal Life of Henrietta Lacks about a woman whose cervical cancer cells were harvested without her permission in the 50s and cloned again and again.

The cases focus on such topics as cloning, diabetes, drug dosages, natural disasters, global warming, nuclear power, skin cancer, stem cell research, population collapse, ecotourism, and many more.