Sentences with phrase «cancer cell diversity»

Not exact matches

For a cancer with very high genetic diversity (like AML) however, the unintended effect of treatment is often to select for the most aggressive, resistant cells, clearing away their competitors and furnishing them with all the resources they need to flourish.

Generally speaking, the seriousness of a given cancer diagnosis may be linked with genetic diversity in cancerous cells.

A new method to take the DNA fingerprint of individual cancer cells is uncovering the true extent of cancer's genetic diversity, new research reveals.

«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.

The results validated a previous group's discovery that measurement of the genetic diversity between Barrett's cells in any given lesion is a good predictor of which patients are at high risk of developing cancer.

The team has already revealed a huge amount of genetic diversity between cancer cells taken from different sites within each man's prostate.

Professor Steven Bova, based at the University of Tampere, Finland, and head of ICGC prostate cancer UK metastatic studies, said: «The diversity we've found suggests multiple biopsies might be needed to identify the «trunk» of the cancer's tree of mutations — we need treatments that target these core weaknesses to destroy all cancer cells in a clean sweep, rather than trimming the branches.

This unusually thorough list helped the researchers tease out subtle differences between generations of same cancer cells treated with chemotherapy and chart how the cancer cell community increased diversity among its members through RNA.

In this video Dr. Odunsi discusses a new study that found that higher T - cell diversity in ovarian cancer is associated with poor overall survival.

Now, scientists at the Salk Institute have uncovered details about how cancer is able to become drug resistant over time, a phenomenon that occurs because cancer cells within the same tumor aren't identical — the cells have slight genetic variation, or diversity.

These new findings may potentially point to a «switch» to turn off this diversity — and thereby drug resistance — in cancer cells.

To uncover how groups of cancer cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed dishes of human pre-cancer and metastatic breast cancer cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.

The most rigorous genetic sequencing ever carried out on a single tumor reveals far greater genetic diversity among cancer cells than anticipated.

So despite their diversity, all cancer cells share one critical thing in common: they are absolutely dependent for their survival on their ability to hijack telomerase (or, less frequently, ALT).

Overall the goal is to eat a rainbow of foods so we are getting a diversity of antioxidants to protect our cells from damage and help prevent cancer.

Other heritable conditions that are related to loss of genetic diversity and inbreeding include cataract, various heart valve defects including pulmonic stenosis, hydrocephalus, cysteine urolithiasis, and hiatal hernias; immunologic disorders that include a propensity for severe demodectic mange indicative of immunodeficiency, allergies associated with atopic dermatitis and ear infections, and autoimmune diseases such as hypothyroidism; and cancers including glioblastoma, mast cell sarcoma and lymphoma [15, 16].