Sentences with phrase «cancer cell interactions»

Delineating breast cancer cell interactions with engineered bone microenvironments.

Not exact matches

This suggests that «the python intestine may represent a valuable model for studying the interactions of metabolism with the regulation of cell division / death and WNT signaling relevant to cancer,» the researchers said.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

Development of new therapies for the prevention and treatment of prostate cancer bone metastasis depends on understanding the dynamic reciprocal interactions between prostate cancer cells and the bone microenvironment.

DMNT inhibitors, such as 5 - azacytidine and decitabine, boost the interactions of PARP inhibitors to block these proteins even further, causing cancer cell death, the researchers found.

When combined, these agents cause interactions that significantly disrupt cancer cells» ability to survive DNA damage, according to a preclinical study published in the journal Cancercancer cells» ability to survive DNA damage, according to a preclinical study published in the journal CancerCancer Cell.

They found that besides traveling in the bloodstream, melanoma cells could also move along the abluminal, or outside, surface of blood vessels by way of angiotropism, a biological interaction between the cancer cells and the blood vessel cells.

Learn about the latest approaches to assessing cancer - immune interactions («immune profiling») using FFPE tissue sections, multiplexed immunofluorescence, and cell phenotyping software

Rather than target a tumor - suppressor gene directly, Ideker and team took the approach of identifying genetic interactions between a tumor suppressor gene and another gene, such that simultaneous disruption of both genes selectively kills cancer cells.

They tested these drugs one at a time for lethal interaction with 112 different tumor - suppressor gene mutations in human cancer cells growing in the lab.

«Right now,» Wells said,» we're hypothesizing that the mechanical interactions modeled by the Shenoy lab explain aspects of cancer and fibrosis, and we're developing the experimental systems to confirm it with real cells.»

The interaction creates heat that kills cancer cells.

Building on this concept, Sushant Patkar of the University of Maryland and colleagues hypothesized that alterations in protein interaction networks in breast cancer cells may change the function of individual genes.

Multi-colored metastasis in the peritoneal lining of the abdomen comprised of red and yellow fluorescent cells demonstrating that pancreatic cancer spreads through interactions between different groups of cells.

This image represents synthetic lethal wiring of a cancer cell, with previously known interactions in red and newly discovered interactions in gray.

Their interaction prevented first - responder immune cells, called macrophages, from triggering reactions that kill cancer cells.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human cancers.

To address these questions, Dang, Altman, and Hsieh collaborated with Penn colleague, Aalim Weljie, PhD, research assistant professor of Pharmacology, using an osteosarcoma cancer cell line to study the interaction of MYC and metabolism in cancer cells.

On the right, the presence within EGFR of a residue able to form additional interactions with osimertinib (as for the L718Q mutant form) prevents its reaction with Cys797 allowing EGFR to work and cancer cells to survive.

The findings detail the interaction among platelets, aspirin and tumor cells and are promising for the future treatment of nonmetastatic cancer, according to the researchers.

«Our findings indicate the existence of long - distance interactions between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.

«Since patients with many types of cancer have elevated levels of myeloisd cells in their blood, it's possible that other tumors could have a similar interaction with bone to increase myeloid cell production.»

In other experiments designed to determine how PTPD2 operates in HER2 - activated breast cancer cells, the team found an «interaction partner,» a lipid called phosphatidic acid, or PA..

Researchers from Guillermo Montoya's team at the Spanish National Cancer Research Centre (CNIO), in collaboration with Isabelle Vernos» Group from the Centre for Genomic Regulation (CRG), have uncovered the molecular interaction between TACC3 and chTOG, key proteins in forming the internal cellular framework that enables and sustains cell division.

This Registered report describes the proposed replication plan of key experiments from «Interactions between cancer stem cells and their niche govern metastatic colonization» by Malanchi and colleagues, published in Nature in 2012 (Malanchi et al., 2012).

They have built proteins that disrupt other protein interactions in cells, including the interactions that prevent cancer cells from dying.

The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other hallmarks of cancer biology.

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treaCancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treacancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate cancer cells to proliferate and evade treacancer cells to proliferate and evade treatment.

Professor Chien's research on how blood flow regulates interaction between the blood stream, blood cells and artery walls also leads to new information relevant to other types of cells, e.g., stem cells and cancer cells.

Topics for the scientific sessions are: Single cell genomics and gene expression Genetic interactions RNAi and somatic cell genetics Protein - DNA interactions Cancer The meeting also highlights existing opportunities for academic and industrial researchers to access automated cell - based and biochemical technologies based at the Karolinska High Throughput Center; home to one of the most sophisticated, state - of - the - art, ultra-high performance liquid handling and analysis platforms in Europe.

Studying cancer with single - cell technology will allow us to unlock the interactions between different types of cells in tumors — and monitor how these interactions change over time, affecting patients» outcomes.

Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model.

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.

Through understanding the biology of cancer cells and their interaction with the immune system we are able to discover and trial novel therapies to induce the immune system to detect and fight cancer cells.

Still, he said, the new data, «has important implications for understanding the genesis of cancer and the interaction between human cells and other microbial or viral organisms in or around us.»

use CRISPR - Cas technology to carry out genome - wide screens of gene - gene, gene - drug and cancer - microenvironment interactions in cells and mice in order to explore fundamental biology and to identify drug targets and drug resistance / sensitisation mechanisms.

Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in vitro via interactions with the transcription factor Sp3.

His success in studying virus - host interactions inspired him to tackle an even more difficult question: How do tumor cells turn against their hosts and eventually kill the cancer patients.

Dissecting these interactions with a combination of cell - biology and systems biology approaches should allow uncovering the tissue specific control mechanisms that are defective in cancer.

We will assemble leading experts to discuss basic immunology, cancer - immune cell interactions, and examine how tumor - associated inflammation can be reprogrammed for therapeutic benefit.

My research team found that just one percent of articles published in Cancer Cell over the past 15 years, the premier journal of cancer research, refer to interactions between cancer cells and their physical enviroCancer Cell over the past 15 years, the premier journal of cancer research, refer to interactions between cancer cells and their physical envirocancer research, refer to interactions between cancer cells and their physical envirocancer cells and their physical environment.

These interactions are critical for cancer cells to adjust to environments chronically depleted of oxygen and nutrients and to maintain cell proliferation and resistance to apoptosis.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

They also show how this interaction can increase proliferation, migration and invasion of tumor cells, three hallmarks of cancer growth and spread.

Current research applications focus on new approaches to a) drug and probe development for neurodegenerative disorders and diseases including Schizophrenia, Alzheimer's, and Parkinson's, b) understanding the structural determinants of antidepressant binding to neurotransmitter transporters, c) cardiac arrhythmia as caused by the complex interplay of potassium channel regulation and drug interactions, d) multidrug resistance in cancer and bacterial cells related to multidrug transporter proteins, and e) structural basis of viral infections and antibody activity.

Loss of RUNX1, a key regulator of estrogen receptor - positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

This study defines a network of synthetic sick / lethal interactions with a set of query genes in a series of isogenic cancer cell lines.