Sentences with phrase «cancer cell mechanisms»

Earlier research suggests these compounds are able to negatively affect critical cancer cell mechanisms, such as those responsible for programmed cell death (apoptosis) and for proliferation.

Not exact matches

Immune oncology drugs use a mechanism to enable the immune system to «uncloak» hidden cancer cells in the body and then attack them.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

This implies that cancer genes, and the mechanisms that allow tumour cells to evade apoptosis, «have deep evolutionary roots».

Researchers have discovered a mechanism that explains how reducing sugar can cause cancer cells to die.

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

The lab that I work in is primarily interested in understanding how and why certain cancers are more likely to spread to the skeleton, and my personal project has focused on uncovering new mechanisms that the cancer cells use to communicate with other cells in the bone.

In one respect the first look is unnerving, because the chemical mechanisms that seem to drive the cancer cell astray are not different in kind from mechanisms at work in the normal cell.

Cancer cells are no exception, and are subject to the two overarching mechanisms described by Charles Darwin: chance mutation and natural selection.

During the sessions, U.S. and Cuban scientists explored such topics as the molecular mechanisms cancer cells employ to evade the body's immune system, new tools to image and manipulate that system, and ways to rethink how such therapies can best be deployed to reach patients where they receive health services.

The findings, published in Proceedings of the National Academy of Sciences (PNAS), define a mechanism in which the oncogenes turn on a protein called RSK2 that is required for cancer cells to move.

Seeking one mechanism to explain the induction of cancer by many different agents, Huebner and Todaro had suggested that retrovirus oncogenes are a part of the genetic baggage of all cells, perhaps acquired through viral infection early in evolution.

If this is the case, then cancer cells do, in fact, exploit the very mechanisms that make it possible for a fetus to survive inside a woman's womb.

The Cent - 1 molecule kills cancer cells through a mechanism similar to that of the template drug Rigosertib that is currently under commercial development.

The new discoveries show that bacteria toxins in some patients enable cancer cells to send off signals that obstruct and change the immune defence mechanism, which would otherwise fight the cancer cells.

Previous work from Shenoy's group has shown that the relationship between cancer cells and the extracellular matrix is dynamic, containing feedback mechanisms that can change the ECM's properties, including overall stiffness.

But Whitehead Institute researchers have found a mechanism underlying this resistance — a mechanism that naturally occurs in many diverse cancer types and that may expose vulnerabilities to drugs that spur the natural cell - death process.

«We've long known that NF - kB promotes cancer development by subverting apoptosis, an internal safety mechanism that otherwise would cause cancer cells to self - destruct,» says principal investigator Denis Guttridge, PhD, professor of molecular virology, immunology and medical genetics and of molecular and cellular biochemistry.

«Mechanisms cancer cells use to establish metastatic brain tumors revealed by research.»

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibCancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibcancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

In addition to using healthy cells to do their work for them, cancer cells also slowly destroy the skin's immune defence mechanism.

Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cCancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast ccancer cells that leads to chemotherapy resistance in inflammatory breast cancercancer.

Although proteasome inhibitors are very efficient in selective killing of cancer tumor cells grown in a dish (in - vitro), their success in the clinic has largely been undermined by the development of resistance — mechanisms of which are poorly understood.

Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.

The discovery has powerful implications for cancer immunotherapy researchers say: by blocking the mechanism with a drug, it may be possible to turn the attack - suppressing cells into tumor - attacking cells.

«Our work suggests a mechanism for cell lethality involving the regulation of BCAAs as crucial elements in pancreatic cancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD Andcancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD AndCancer Biology, senior author of the Nature paper and president of MD Anderson.

Adult drug resistant cancer cells may contribute to this problem, and the authors discuss these and other cancer drug resistance mechanisms in their recent publication in the September issue of the journal Cancers.

«New mechanism explaining how cancer cells spread.»

«Further research into the detailed mechanisms underlying ASIS in naked mole - rats may shed new light on cancer resistance in the mole - rats and contribute to the generation of non-tumorigenic human - iPSCs, enabling safer cell - based therapeutics,» said Kyoko Miura, an assistant professor at Hokkaido University.

Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

The work published in Cancer Cell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic stratCell complements previous research efforts from the CNIO Melanoma Group, which could lead to the development of novel drugs that selectively target the mechanism of cell autodigestion as a potential therapeutic stratcell autodigestion as a potential therapeutic strategy.

His hunch is that the mechanisms controlling cell division have gone wrong — somewhat like what happens in cancer — and that plaques and tangles are the result.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

Discerning the basic mechanism wasn't enough — Svanborg wanted to find out if the cells might be induced to commit suicide on demand: Could the discovery be developed into a cancer cure?

What's more, the researchers found that blocking this mechanism with HCQ — a drug used to treat malaria that has been shown in previous studies to block autophagy — limited BRAF inhibitor - induced autophagy and enhanced cancer cell death in mouse models.

Rad3 signalling ensures that cells do not divide before DNA damages are repaired and thus provides cancer cells with a mechanism to resist chemotherapy by repairing these DNA damages.

Cancer cells can leverage such mechanisms to escape the immune system response.

The drug's mechanism of action was entirely new: Instead of attacking cancer cells (like chemo), or indiscriminately revving up the immune system (like IL - 2), ipilimumab blocked a single receptor on one type of immune cell.

Our new findings tell us that low oxygen conditions actually encourage certain cancer stem cells to multiply through the same mechanism used by embryonic stem cells.»

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasicancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer MetastasiCancer Metastasis Lab.

Moffitt Cancer Center researchers have discovered a novel mechanism that controls a cell's response to DNA damage.

These techniques are key to understanding the molecular mechanisms underlying cell function in healthy and diseased individuals and the development of diseases like cancer.

The work also reinforces the importance of finding tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.

However, the mechanisms by which tumor cells interact to enhance the spread of cancer remained unclear.

Our body has a system to repair DNA damage (DNA repair mechanism), so why a normal cell turns into a cancer cell and why radiation exposure causes cancer have not been clarified.

University of Alberta researchers have discovered a mechanism that may make cancer cells more susceptible to treatment.

«This remodeling process of the cell proteome by autophagy is an important immune - suppressive survival mechanism for Ras - driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers,» notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.

«Bringing natural killer cells to the tumor battlefield: Scientists discover a mechanism that inhibits tumor growth in skin cancer.»

«This mechanism makes a normal cell, even without cancer stress, get old much faster, and in a detrimental way.»