Sentences with phrase «cancer cell of origin»

Trowbridge hypothesized that analyzing open chromatin in bulk tumor cells could provide a possible improved method to identify cancer cell of origin because of the cell - type specificity of chromatin structure.

«It's incredibly rare to identify a cancer cell of origin and until now no one has been able to track what happens on an individual level to these cells as they mutate and proliferate,» says Professor Blanpain.

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

In the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origin.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

Not exact matches

For over one hundred years, scientists have debated the question of the origins of the lymphatic system — a parallel system to the blood vessels that serves as a conduit for everything from immune cells to fat molecules to cancer cells.

«Researchers identify the cells at the origin of breast cancers.»

«Overall, our studies show that by using modified techniques we will be able to observe non-uniform cancer cells, regardless of their origin,» Polo - Parada said.

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

To seed in the brain, a cancer cell must dislodge from its tumor of origin, enter the bloodstream, and cross densely packed blood vessels called the blood - brain barrier.

This provocative fact allowed him to argue that cell - competition genes could be linked to the origins of multicellular life and that investigating them could help scientists understand and treat cancer.

But a new study suggests that mature cells also play a key role in initiating cancer — a finding that could upend the way scientists think about the origins of the disease.

The discovery of this «cell of origin» promises to accelerate the development of more precise screening tools and therapies for Barrett's esophagus and esophageal adenocarcinoma, the fastest growing form of cancer in the U.S.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

A comparison of these two cancers, published April 9 in the journal Cancer Cell, suggests that they are similar in origin, leading researchers at the University of Cambridge to believe that devils simply may be at greater risk for these kinds of diseases.

Rewinding skin cells back to their origins in the womb could provide a powerful new vaccine against multiple types of cancer.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Further dissecting the MDS stem cells at the molecular level could provide insights into the origins and development of MDS and other blood cancers.

The researchers said the findings fundamentally change the understanding of G1 cell cycle regulation and the molecular origins of many associated cancers.

«Cancer's surprise origins, caught in action: First demonstration of a cancer arising from a single cell.&Cancer's surprise origins, caught in action: First demonstration of a cancer arising from a single cell.&cancer arising from a single cell.»

Researchers at Boston Children's Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal.

Almost 80 percent of cancers have epithelial cell origin.

Dor's own group reports this week that its technique for tracing the origin of circulating DNA detected the expected type of cell death in people with pancreatic cancer, type 1 diabetes, multiple sclerosis, and brain injuries.

The genomic particularities of HeLa cells relate to their origin from an aggressive cancer and subsequent cultivation in laboratories for decades, both of which cause considerable genomic alterations.

In lab experiments, the research team used cell lines derived from 40 patient tumour samples to identify that CD151 contributes to the survival of cells of high - grade serous ovarian cancer origin.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

«Esophageal cancer «cell of origin» identified.»

Sheltzer's team proposes that these cells rapidly evolved to acquire different mutations that would confer a survival benefit — perhaps enabling them to grow in new environments, just as cancer cells that become metastatic evolve so as to be able to detach from their tissue of origin and grow at different sites in the body.

Glioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated cell of origin.

One feature of the tumor cells that the researchers were particularly interested in was their sensitivity to cancer drugs, and here too they found a correlation with the cell of origin.

«We discovered that several important characteristics of the cancer cells could be linked to the tumor's cell of origin.

«Using healthy skin to identify cancer's origins: Cancer - linked DNA changes in 25 per cent of normal skin cells.&cancer's origins: Cancer - linked DNA changes in 25 per cent of normal skin cells.&Cancer - linked DNA changes in 25 per cent of normal skin cells.»

The findings illuminate the first steps cells take towards becoming a cancer and demonstrate the value of analyzing normal tissue to learn more about the origins of the disease.

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

«On the cancer side, I think that these cells are very strong candidates for cell of origin.

However, cells with too short telomeres can lose capping function leading to a cellular catastrophe and genetic instability: the origin of many cancer types.

Rather Duesberg has also developed a novel theory about the origins of cancer, one that supposes a derangement of the chromosomes, rather than of individual genes, is the spark that ignites malignant changes in cells.

Scientists identify «cell of origin» in skin cancers.»

Scientists have identified for the first time the «cell of origin» — in other words, the first cell from which the cancer grows — in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours.

Cancer research should focus on the «fundamentals of the origins» of mutating and rapidly reproducing cancer cells that make the disease so difficult to Cancer research should focus on the «fundamentals of the origins» of mutating and rapidly reproducing cancer cells that make the disease so difficult to cancer cells that make the disease so difficult to treat.

Learning what type of cell starts a particular cancer — the «cell of origin» — is extremely valuable, providing insights into tailored therapies that are most likely to work.

A recent paper in Cancer Cell reveals the power of integrated genomic datasets for understanding cancer origins and treaCancer Cell reveals the power of integrated genomic datasets for understanding cancer origins and treacancer origins and treatment.

25) Barker N., Ridgway R.A., van Es J.H., van de Wetering M., Begthel H., van den Born M., Danenberg E., Clarke A.R., Sansom O.J., Clevers H. Crypt Stem Cells as the Cells - of - Origin of Intestinal Cancer Nature 457:608 - 611 (2009)

51) Drost, J., van Boxtel, R., Blokzijl, F., Mizutani, T., Sasaki, N., Sasselli, V., de Ligt, J., Behjati, S., Grolleman, J.E., van Wezel, T., Nik - Zainal, S., Kuiper, R.P., Cuppen, E., and Clevers, H. Use of CRISPR - modified human stem cell organoids to study the origin of mutational signatures in cancer.

«Use of CRISPR - modified stem cell organoids to study the origin of mutational signatures in cancer»

This abnormality helps drive malignancy at the point of origin, and facilitates cancer stem cells to renew over the long term.

«Knowing the cell of origin of cancer cells can provide insight into tumor subtypes and possibly diagnostic and therapeutic benefit,» says JAX Assistant Professor Jennifer Trowbridge, Ph.D., the lead author of the study published on July 11 in Nature Communications.

Cancer is an extremely complex biological phenomenon showing enormous variability (e.g., age of patient, cell of origin, general health status, genetic background, location in an organ, nutritional status, presence or absence of continued development of neoplasia (i.e., carcinogenesis), presence or absence of enhancers, rate of growth and division, type and dosage of therapy administered, etc.).

Yet, as cancer is a complicated disease of the immune system involving excessive growth of cells having altered DNA, the origins of the disease never have singular nor finite cause.

These, together with the origin or type of tumor, the grade (differentiation or degree with which the tumor cells resemble normal cells) and stage (how large it is and extent of spread) indicate how the cancer will behave (the prognosis).