Sentences with phrase «cancer cell populations»

Here we undertake a synthesis of central concepts for evolutionary predictions, based on examples of microbial and viral systems, cancer cell populations, and immune receptor repertoires.

Our previous work has shown that the CD44 + and CD44 + α2β1 + prostate cancer cell populations are enriched in tumorigenic and metastatic CSCs, whereas the α2β1 + prostate cancer cells most likely mark fast - proliferating tumor progenitors (28, 29).

Here, we elaborate on how these findings pertain to cancer cells dispersed in the tumor - adjacent stroma of breast cancer tissues, and how BH3 - mimetics may provide a therapeutic strategy to eliminate cancer cell populations that have passed through an EMT.

In the publication, Bhang and coworkers used the ClonTracer library to determine whether or not cancer cell populations resistant to drug treatments arise during treatment or are preexisting in the parent population prior to the start of treatment.

Not exact matches

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

Tumours grow through a process of Darwinian evolution, where cancer cells develop an advantageous mutation that allows them to survive and multiply, producing a population of cells which can mutate further.

Previous studies have examined cancer stem cells (CSCs)-- small populations of cells within a tumor that are resistant to chemotherapy.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

He then evaluated the levels of specific microRNAs in populations of highly metastatic, compared to poorly metastatic, cancer cells taken from the same patient.

Though chemotherapy might kill most of the cancer, tiny populations of drug - resistant cancer cells manage to survive and propagate.

The KU researcher said that new evidence suggests that cancer originates and progresses by a small population of cells known as cancer stem cells.

According to Semenza, «Chemotherapy may kill more than 99 percent of the cancer cells in a tumor but fail to kill a small population of cancer stem cells that are responsible for subsequent cancer relapse and metastasis.»

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.

Nearly all of the cancer cells died as a result, but a residual population of tumor cells survived and became dormant.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

By measuring for the presence of a molecule associated with cell division, the scientists determined that this residual population of dormant cancer cells consisted of an indolent as well as a quiescent population.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

This population of cells suppresses the growth of cancer - fighting immune cells, thereby limiting the ability of the immune system to fight off cancer.

Reporting their laboratory findings in the journal Aging, the team observed that addition of DPI to a mixed population of cells eliminated the tumour initiating cancer stem cells.

By adding measured amounts of anhydrotetracycline (ATc) to a population of genetically modified yeast cells, scientists at the University of Texas M. D. Anderson Cancer Center were able to precisely control the production of green fluorescent protein.

«If the CD117 cell population does lead to tumor initiation or cancer reoccurrence, this cell marker could become a therapeutic target,» she says.

The research group plans to move forward with more - advanced technology and larger populations to investigate field cancerization in other lung cancer subtypes, such as small - cell lung cancer, in smokers and in lung cancers that develop in non-smokers.

Researchers at Dana - Farber Cancer Institute this year announced that a previously unrecognized population of cells in the lymph nodes signals the immune system to tolerate conditions that would normally prompt an attack.

Their recent study, which appears as the cover article in the May issue of Cancer Research, shows that mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment.

What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.

«Our study suggests that if a cancer - causing mutation occurs in the neural stem cell population in the SVZ, it gives rise to the proneural or the neural glioblastoma subtype.

A team of researchers at the Massachusetts General Hospital and Harvard Medical School in Boston has developed technologies for precision measurement of cell migration speed before and applied the new tool to study the variations of migration speed in population of cancer cells.

In healthy individuals, MDSCs regulate immune responses and tissue repair, and the population of these cells rapidly expands during inflammation, infection and cancer.

Even in the early stages of tumor growth, the microRNA remains active to keep the cancer stem cell population down.

A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or «epigenetic») modifications made to the protein packaging of DNA using a small population of cells.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

«We wanted to know if eradication of this very small population of stem cells would improve organ function, and both kidney and heart were completely protected from developing fibrosis - related complications (e.g., kidney failure and heart failure),» said Humphreys, who also heads the Onco - Nephrology Program at the Dana - Farber Cancer Institute.

However, another report found that miR - 7 expression correlated with poorer prognosis of breast cancer, and these apparently conflicting results suggest that miR - 7 may be differentially expressed in a specific cell population of breast cancer (26).

Cancer stem - like cells (CSC) are a minor population of tumor mass and considered to have abilities of tumor initiation, differentiation, and chemoresistance (1).

To devise a potential new therapy, the investigators engineered a population of bone marrow derived mesenchymal stem cells loaded with oncolytic herpes simplex virus (oHSV), which specifically kills dividing cancer cells while sparing normal cells.

C, primary breast cancer cells isolated from patients with advanced cancer were directly infected with KLF4 or control lentivirus, and the CSC population (CD24 − CD44 + ESA +) was measured by FACS after culturing the cells for 72 hours in low - attachment plates.

Attempts to eliminate the tumor - initiating cell population generated by EMT are hampered by their increased resistance against most conventional cancer therapeutics.

Researchers at the Université libre de Bruxelles, ULB define for the first time the tumor transition states occurring during cancer progression and identify the tumor cell populations responsible for metastasis.

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

Cancer, the uncontrolled growth and migration of a small population of cells within a given tissue, is one of the leading causes of death in the United States in older adults.

Unlike other studies on p53, however, which target cell populations that average many cells together, Dr. Lahav developed a new approach, quantifying p53 at high temporal resolution in single cells and taking into account that «individual cell decisions are crucial in the development and treatment of cancer.»

Phillips and colleagues [47] reported that the non-adherent population of monolayer cultures of breast cancer cells has the ability to initiate mammosphere formation after irradiation.

Dr. Cui's research concluded that the cancer resistance was mediated by a specific population of leukocytes (granulocytes and monocytes) and that these cells, when transfused to a mouse with cancer, would cure the cancer.

These findings strongly suggest that we have succeeded in isolating a unique metastatic CSC population by exposing breast cancer cells to repetitive cycles of hypoxia and reoxygenation.

He employs mouse models to facilitate in - vivo lineage tracing from candidate stem cell populations and to assess their contribution to cancer initiation and progression.

We are currently exploring this possibility and hope to elucidate the mechanism and relevance of the cycling hypoxia - selected cell population in breast cancer progression.

A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer

«Using a new technique, we were able for the first time to separate low - PSA and high - PSA prostate cancer cells, which led to the discovery of a low - PSA population of cancer stem cells that appears to be an important source of castration - resistant prostate cancer,» says Tang.