Sentences with phrase «cancer cell subpopulation»

Strikingly, this cancer cell subpopulation displayed enhanced expression of Bcl - xL, strongly suggesting that the upregulation of this antiapoptotic protein also supports the survival of invasive cancer cells within patients.

Not exact matches

«We have identified a code of «molecular switches» that control a very aggressive subpopulation of brain cancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell arcancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell arCancer Research, co-lead author of the Cell article.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

Hence, BH3 mimetics might represent an attractive approach of eliminating resistant subpopulations of cancer cells, thereby targeting both tumor cell invasion and cancer relapse.

Sphere - forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines.

Within tumors, there exists a subpopulation called the «cancer stem cells» (CSCs).

Cancers contain genetically different subpopulations of cells, called subclones.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

In our study, we found that exposing metastatic breast cancer cell lines to hypoxia and reoxygenation cycles induces a unique subpopulation that is highly metastatic and exhibits stem - like and EMT phenotypes.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

Using a qRT - PCR - based method, we found dramatic decreases of epithelial miRNAs (miR200c and miR205) in the F3 subpopulations compared with the parental breast cancer cell lines (Figure 6e).

Subpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for canSubpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for cansubpopulations could lead to new targets for cancer treatment.

The commentary highlights the possible fundamentally different and even opposing functions of intestinal fibroblast subpopulations in regulating inflammation and tumour formation and underscores the need to further characterize these cells to reveal new mechanisms underlying pathogenesis of chronic inflammation and cancer.

We then isolated and exposed this novel subpopulation to additional cycles of hypoxia / reoxygenation and established a distinct subpopulation of cells from these two breast cancer cell lines.

BUFFALO, New York, July 6, 2016 — A research team from Everon Biosciences, Inc. and Roswell Park Cancer Institute has identified a specific subpopulation of immune cells accumulating in old mice that are likely contributors to aging and age - related diseases.

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Our results led us to speculate that there might be a metastatic subpopulation within stem - like cancer cells since other studies have shown that CSC phenotype alone may exhibit invasive property in vitro but is inadequate to determine or predict in vivo metastasis.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

Cancer stem cells (CSCs) known as tumorigenic cells are biologically distinct from diverse subpopulations.

The project «Preprogrammed versus stochastic clonal evolution of relapsing Acute Myeloid Leukaemia: Impact on disease development and therapeutic responses» will dissect why the subpopulations of primary human blood cancer cells that drive leukaemic relapse resist relevant clinical treatments in vivo.