Sentences with phrase «cancer cell surface»

We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

Triple negative breast cancers are those that do not have estrogen or progesterone receptors, and do not have an excess of the HER2 protein on the cancer cell surfaces.

Not exact matches

Weeks later, Yee realized that he didn't have the equipment he needed to pluck out of Ziskin's blood the rare (perhaps one in 100,000) T cells that could identify the subtle peptide markers on the surface of her cancer cells and attack the disease.

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

But T - cells appear to be even more promising, because they can react to abnormalities inside cancer cells rather than just on their surfaces.

In many very invasive forms of breast cancer, the cells have too much of the receptor HER2 on their surface.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.

MP1 interacts with lipids that are abnormally distributed on the surface of cancer cells, creating gaping holes that allow molecules crucial for cell function to leak out.

Although some cancers — particularly those that are rife with mutations like lung cancer or melanoma — create more tangible targets on the surface of cells for the immune system to recognize and attack, other malignancies such as prostate and pancreatic cancers have proved more intransigent.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

Instead of displaying the full complement of incriminating proteins on the tumor cell's surface, the dog cancer displays just a few, obfuscating the invasion underway.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

«Cell - surface receptor offers promising breakthrough for pancreatic cancer patients.»

Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can block pancreatic tumor formation and recurrence after radiotherapy.

But when PD - 1 binds to proteins called PD - L1 and PD - L2 on the surface of certain cancer cells, the T cells essentially become paralyzed: the immune attack on cancer is called off.

They found that besides traveling in the bloodstream, melanoma cells could also move along the abluminal, or outside, surface of blood vessels by way of angiotropism, a biological interaction between the cancer cells and the blood vessel cells.

They have also isolated specific receptors on the surfaces of cancer cells that green tea compounds may interact with.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

Cadherin - 22 is located on cell surfaces, allowing hypoxic cancer cells to stick together and migrate collectively as a group, said Uniacke.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Triple - negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces.

The team, based at UCL, had already found that prostate cancer cells have more of the NAALADL2 molecule on their surface compared to cells from healthy tissue.

A pancreatic cancer vaccine could be made of whole pancreatic cancer cells, treated so they can't replicate, but modified to present certain molecules on the surface of those cells.

It's also unclear at this point, he says, exactly how annexin A2 encourages pancreatic cancer cells to release Sema3D, but the researchers suspect annexin A2 may act like a bodyguard to Sema3D, sheltering and guiding the protein as it makes its way toward an exit at the cell surface.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

The experimental drug cediranib blocks the cell surface receptor VEGF, which stimulates the growth of new blood vessels to feed the growth of tumours,» explains study researcher Dr Paul Symonds, of the Department Cancer Studies & Molecular Medicine at the University of Leicester, UK.

Toner pumped samples of whole blood through the channels, which were coated with an antibody designed to trap any cancer cell that carries a common surface protein, much as flypaper snags pesky insects.

The problem with viruses that typically cause cancer, though, is that they tend hide out of reach — inside of rather than on the surface of cells.

Cancer can be chillingly personal, right down to your cell surface.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

These cells have different factors on their surfaces which determines how «sticky» the cells are and whether they are responsible for mediating the cancer cells binding to the blood vessel walls.

They may also induce the production of antibodies that bind to molecules on the surface of cancer cells.

«When a cancer cell comes into contact with it, a protein on the cell's surface, known as APP, activates DR6.

Comparing the markers on these stem cells with those on the surfaces of cancer cells, Johnson adds, will also help scientists determine if stem cells contribute to prostate malignancies.

HER2 - positive breast cancer, which is associated with poor prognosis, has been traced to an excess of signaling through receptors, or docking ports, called HER2 found on the surface of certain mammary epithelial cells.

In human medicine EGFR is frequently used as the target of cancer immunotherapy because many cancer cells bear this receptor on their surface.

Though similar to healthy cells, cancer cells often display unique antigens on their surface, which can be exploited to develop cancer immunotherapies.

Since cancer cells bear very specific antigens on the surface, the corresponding antibodies bind to these molecules and thus inhibit tumor growth.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

Most integrin inhibitor drugs target their adhesive function and block them on the surface of the cancer cell.

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

One of the immunotherapeutic approaches that has been explored thus far relies on the use of monoclonal antibodies that specifically target a protein present on the surface of prostate cancer cells called prostate specific membrane antigen (PSMA) to elicit an anti-tumor immune response and control the cancer.

They work by sticking to specific proteins found on the surface of cancer cells, flagging them up to be killed by the immune system.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.