Sentences with phrase «cancer cell toxicity»

«This research study clearly demonstrates the anticancer potential of omega - 3 fatty acids,» he said, adding that while the study showed significant cancer cell toxicity, it is too soon to tell whether the approach is able to kill every cancer cell.

Not exact matches

Preclinical trials indicate potential for noscapine as a cancer drug with less toxicity to healthy cells than currently available chemotherapies.

Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.

«We are looking to optimize the combinations of targeted therapies and the scheduling of those therapies so we can improve tumor shrinkage and minimize potential toxicities for a patient,» said Andrew Aplin, PhD, Associate Director for Basic Research and the Program Leader for Cancer Cell Biology and Signaling (CCBS) in the NCI - designated Sidney Kimmel Cancer Center at Jefferson Health.

«If immune cell therapies for cancer or autoimmune diseases (like rheumatoid arthritis, for example) are going to be safe and effective alternatives to more traditional medications, we must gain control over the activity of the cells to reduce risks of toxicity to the patient,» said Roybal.

Knowing that cancer cells have a different metabolic profile, the team surmises that this can inform when to treat cancer — when normal cells are quiet — to decrease toxicity, while increasing efficacy against the always - awake cancer cell.

The toxicity of chokeberry extract on normal blood vessel lining cells was tested and found to have no effects up to the highest levels used (50 ug / ml), suggesting that the cell death effect is happening in a way other than through preventing new blood vessel formation (anti-angiogenesis), a process that is important in cancer cell growth.

This would have multiple goals of killing cancer cells, creating a hostile biological environment for their growth, reducing toxicity from the drug regimen and avoiding the development of resistance to the cancer drugs being used.

If the engineered human T cells do produce a robust cancer attack — and don't generate toxicity by also attacking healthy cells — the next step would be clinical trials, He says.

Researchers at the University of Chicago Medical Center have isolated the gene for a component of the elusive molecular machinery that plays a key role in making cancer cells immortal, offering scientists a tantalizing target for new anticancer drugs of greater effectiveness and lower toxicity.

Despite the tremendous progress in drug cancer chemotherapy, most of the drugs used today have a pronounced toxicity effect, killing normal cells along with cancer cells.

Furthermore, the drug was characterized as agonist of casein kinases 1 (CK1); however, this effect was not confirmed and in colon cancer cells there was no correlation between PPAM toxicity and mutations in Wnt signaling mediators [57, 58].

These mistakes can cause big problems, including cell toxicity and cancer.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

«Our efficiency in killing the cancer cell was very high with no toxicity to normal cells,» said Lin.

Johns Hopkins researchers then study stem cell infusion as therapy for cancer treatment toxicity, diabetes, cystic fibrosis, and other diseases.

His scaffold cleared two hurdles in a single bound: the long slog through tissues in which most cancer - hunting T cells are lost, and the toxicity that immune - stimulating factors can cause when administered systemically.

Arnida Malugin A, Ghandehari H. Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres.

«This is why the drug is mostly released inside cancer cells, which decreases the general concentration of the drug in the organism, thus preventing toxicity,» Matveyev notes.

RALEIGH, NC — Researchers at North Carolina State University and the UNC School of Medicine have developed a new drug delivery technique that uses a biodegradable liquid metal to target cancer cells while limiting toxicity to normal cells.

Tumor - targeting nanoparticles loaded with a drug that makes cancer cells more vulnerable to chemotherapy's toxicity could be used to treat an aggressive and often deadly form of endometrial cancer, according to new research...

Thus, these approaches are characterized by inherent low toxicity and the possibility to use them in conjunction with conventional anti-cancer therapies targeting cancer cells such as radiation or chemotherapies.

[3] Low muscle mass is associated with increased risk of dose - limiting chemotherapy toxicities, such as low white blood cell count and reduced overall survival, and therefore it is extremely important to maintain muscle mass in advanced cancers.

UPDATE: Mario makes a great point in the comments: fasting prior to chemotherapy reduces toxicity to normal cells but increases toxicity to cancer cells.

In cancer therapy, melatonin counteracts chemotherapy toxicity, by acting as an anti-oxidant agent, and promotes apoptosis (programmed cell death) of cancer cells, thus enhancing the toxicity of chemotherapy.

Antioxidants protect noncancerous cells from the toxicity of chemotherapy and prevent free - radical damage involved in cancer development and treatment.

(I note in the comments that the benefits from poisoning gut pathogens and cancer cells might outweigh the damage from direct toxicity.

Chemotherapy involves the use of drugs that are designed to be damaging to cancer cells but unfortunately, they typically have some toxicity for healthy cells as well.

Chemotherapy uses drugs that are damaging to cancer cells, but may also have some toxicity for healthy cells.