Sentences with phrase «cancer cells blocked»

Conversely, shutting down sarcosine production in cancer cells blocked invasion.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

«Inflammatory breast cancer is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast.

Rather, cancer cells block lymph vessels in the skin of the breast, causing it to look red and feel warm.

Not exact matches

It's only been tested on mice so far, but the results are tremendously promising for an antibody Stanford researchers have been experimenting with that blocks the body from «eating» cancer cells.

Recent findings from the University of Texas MD Anderson Cancer Center suggests that capsaicin, the active chemical compound that gives chile peppers their heat, may reduce and even block chronic inflammation pathways in cancer Cancer Center suggests that capsaicin, the active chemical compound that gives chile peppers their heat, may reduce and even block chronic inflammation pathways in cancer cancer cells.

Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cells.

Inflammatory breast cancer is a rare and aggressive form of breast cancer that occurs when malignant cells block the skin and lymph vessels of the...

Chronic cigarette smoke exposure, as noted in many human cancers, tends to block these cell maturation genes from properly turning on, says Baylin.

The antibody blocks PD - 1 proteins, freeing T cells to attack the cancer.

To test whether those cancer genes help the cell survive, they tried blocking them.

While the combination therapies block off the principal pathway that cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles on a detour route, make use of additional pathways to continue growing and spreading.

They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Nicotine from cigarettes is a highly addictive drug that can stimulate cell growth and block cell death — two hallmark characteristics of cancer.

Once we know all cancer's major evolutionary escape routes — and it turns there may be just a few — it may be possible to block them all off with T - cells or drugs like them.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Schwarz and her colleagues used three different drugs, alone and in combination, to deprive cervical tumors of glucose and block downstream metabolic pathways that help protect cancer cells from building up toxic free radicals.

«Cancer cells» communication path blocked.»

Women with high levels of FGF1 were less likely to respond to platinum - based drugs, but blocking the gene makes their cells lose their resistance (British Journal of Cancer, DOI: 10.1038 / bjc.2012.410).

With that knowledge, they screened more than four dozen monoclonal antibodies — unique agents that can stop cells from growing or forming tumors and can be mass produced — before finding two that block tumor creation in both types of cancer.

There is currently a PD - 1 antibody on the market that blocks T cell exhaustion in patients with solid tumors, like lung cancer and melanoma.

The discovery has powerful implications for cancer immunotherapy researchers say: by blocking the mechanism with a drug, it may be possible to turn the attack - suppressing cells into tumor - attacking cells.

In the study, they found that miR - 182 suppressed Bcl2L12, a cancer gene that blocks cancer cell death in response to chemo - and radiation therapy.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

Checkpoint inhibitors block that handshake, which alerts immune cells to cancer cells and target them for destruction.

A phase 3 trial of lenalidomide / dexamethasone plus ixazomib (Ninlaro ®), a «proteasome inhibitor» that blocks the ability of cancer cells to reuse certain proteins.

«The knowledge we have gained may be applicable for future intervention of this process to block the replication of viral pathogens and cancer cells.»

«For this reason, we decided to combine vitamin C with a PARP inhibitor, a drug type known to cause cancer cell death by blocking the repair of DNA damage, and already approved for treating certain patients with ovarian cancer.»

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

DMNT inhibitors, such as 5 - azacytidine and decitabine, boost the interactions of PARP inhibitors to block these proteins even further, causing cancer cell death, the researchers found.

They were able to block proliferation of several cancer stem cell lines.

PARP inhibitors target and block proteins which cancer cells depend on to repair DNA for their survival.

But their overriding interest in BPTES, says Slusher, was in how it works: by blocking the production of glutamine, an amino acid that acts as a building block of cells and is used frequently by pancreatic cancers to create more cancer cells.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

Moreover, epalrestat, a drug that inhibits AKR1B1 and is approved in Japan to treat peripheral neuropathies associated with diabetes, was similarly able to block the growth and metastasis of human basal - like breast cancer cells.

«In order to block tumor recurrence after radiation therapy, we used an antibody to target and inhibit these cancer stem cells,» said Dr. Xu.

The studies not only point to the future possibility of specific microRNAs as a treatment for colorectal cancer, but also to the importance of external metabolic events conducted outside the cancer cell in the progression of the disease — factors that could someday be targeted to help slow metastasis, or even block it entirely.

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking thCancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking thCancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking thcancer that no longer responded to standard hormone - blocking therapy.

Liang Xu, Ph.D. member of the KU Cancer Center's Drug Discovery, Delivery and Experimental Therapeutics program and associate professor of molecular biosciences at KU, has discovered that targeting a cell - surface receptor called «CD44s» can block pancreatic tumor formation and recurrence after radiotherapy.

«Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,» he said.

«We have shown that when FBW7 is functionally inactivated this leads to a block of degradation of the stem cell protein SOX9 which becomes more stable in the brain cancer cells,» said first author Aldwin Suryo Rahmanto at the department of Cell and Molecular Biolcell protein SOX9 which becomes more stable in the brain cancer cells,» said first author Aldwin Suryo Rahmanto at the department of Cell and Molecular BiolCell and Molecular Biology.

Autophagy is a process by which cancer cells recycle essential building blocks to fuel further growth.

«It is currently impractical to directly restore Apc function in patients with colorectal cancer, and past evidence suggests that completely blocking Wnt signaling would likely be severely toxic to normal intestinal cells,» Lowe says.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

What's more, the researchers found that blocking this mechanism with HCQ — a drug used to treat malaria that has been shown in previous studies to block autophagy — limited BRAF inhibitor - induced autophagy and enhanced cancer cell death in mouse models.

The cancer cell thinks it's getting cholesterol to provide the nutritional building blocks needed to grow and proliferate.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

But scientists at the Lewis Katz School of Medicine at Temple University (LKSOM) now think they can help overcome that problem, thanks to their discovery of a small molecule that selectively kills BRCA - deficient cancer cells by blocking the activity of an alternative DNA repair pathway.