Sentences with phrase «cancer cells break»

These cancer cells break away from the initial tumor and spread to other parts of the body.

More specifically, the Warburg effect describes the reality that cancer cells break down sugars more rapidly than most other types of cells.

Metastasis is a life - threatening condition in which cancer cells break away from the site where they formed to other areas of the body.

Cells suspended in a stiff matrix were more likely to work their way through the matrix to other side of a serum gradient, analogous to how metastasizing cancer cells break free from their tumors.

Then tiny clumps of cancer cells broke away from the tumor and floated away in the fluid flowing through the capillary.

Not exact matches

Even in winter, the sun's damaging ultraviolet rays can dry your skin, make it look older, break down cells and even cause cancer.

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

A late breaking subanalysis of the phase III CONVERT trial presented at the European Lung Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (cancer (SCLC).

In contrast, the cancer cells often had subsets of miRNAs that were not connected to the rest of the network — rogue groups that had broken free.

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

In cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstream.

To migrate from a primary tumor, a cancer cell must first break through surrounding connective tissue known as the extracellular matrix (ECM).

Metastatic cancer cells have the ability to break free from tissue, circulate in the blood stream, and form tumors all over the body, in a way acting like blood cells.

ON THE ROAD Breast cancer cells may break away from the main tumor in clumps, already bearing most of the mutations that will drive cancer recurrence, a study suggests.

Previous studies of genetic alterations in lymphoma and lung cancer have found that certain genetic mutations — specifically when part of a gene breaks off and gets fused to another — can inappropriately switch on ALK, driving cancer cells to grow and divide.

Circulating tumor cell (CTC) clusters — clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.

Batimastat does not work this way: instead, it is designed to keep cancers in check by preventing malignant cells breaking away and forming secondary tumours elsewhere in the body.

«We're seeing now that the mechanics are going to drive whether cancer cells can migrate faster or slower or break away or not.

In these vesicles, we saw the EGFR and HER2 receptors being broken down, but we also saw our negative control receptor, c - MET,» said Dent, who is the Universal Corporation Chair in Cancer Cell Signaling and a member of the Cancer Cell Signaling research program at Massey.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

Importantly, like cancer cells with other mutations in the HR repair pathway, CHD1 - depleted prostate cancer cells proved to be hypersensitive to chemotherapeutic drugs causing DNA breaks, such as Mitomycin C, Irinotecan and PARP inhibitors.

Min Huang, Jian Ding, and colleagues at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, discovered that inhibiting PGAM1 made cancer cells more sensitive to drugs that induce breaks in both strands of the cells» DNA.

Now, a research team led by the Georgia Institute of Technology has developed a new treatment to thwart it by, in a sense, breaking cancer cells» legs.

Now researchers have discovered a mutation that fixes a key protein that's often broken in cancer cells.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

L1CAM protein (brown in top panel) resides in cells poised to break from the cancer's bulk (cells with b - catenin are brown in bottom panel) and invade other tissues.

«This work ties together the study of cell metabolism and cancer chronotherapy — If cells don't have to «rest,» they may replicate all the time, with no breaks at all.»

«Breaking down cancer cell defenses: Inhibiting membrane enzyme may make some cancer cells more vulnerable to chemotherapy.»

The cancer originated in some unfortunate clam somewhere and has persisted ever since as those cancerous cells divide, break free, and make their way to other clams.

This allows cancer cells to break off from tumors, spread throughout the body (in blood or other fluid) and form new tumors at distant sites — a process called metastasis.

Cell phones can not cause cancer, because they do not emit enough energy to break the molecular bonds inside cells.

A key question in cancer research has been how cancer cells are able to survive once they break away from a tumour to spread around the body.

Turning off the pathway can trigger cancer cells to self - destruct because the machinery used to untangle the DNA fails, meaning it is torn apart as the cell divides — ravaging and causing huge breaks in the code which lead to the cancer cells» demise.

The study of human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from other cells often killed them and many experiments ended in failure).

The study, published in Nature Communications, examined the changes that occur in cancer cells as they break away from tumours in cell cultures, zebrafish and mice.

The acidic environment inside the cancer cell then begins to break apart the pseudo-platelet — freeing the Dox to attack the cancer cell's nucleus.

Although this research was conducted on ovarian cancer cells, the ground - breaking results are applicable to a wider range of cancers.

«This paper shows that an increase in physical mobility of DNA strands is something that happens inside mammalian cells every time there is a break in the DNA,» says de Lange, who is also American Cancer Society Professor, and Director of the Anderson Center for Cancer Research at Rockefeller.

These tumors might yield to a new kind of drug known as a PARP inhibitor that kills cancer cells by hijacking the cell's ability to mend DNA breaks.

One treatment is a vaccine that targets a structure on the outside of cancer cells, while the other is an altered enzyme that breaks apart RNA and causes the cell to commit suicide.

As described in a study posted online May 21 by Science magazine, the strategy uses tumor cells» own protein - chopping machinery to break down and dispose of proteins that drive cancer growth.

Like most machinery, the mitotic spindle can malfunction, and when it does, DNA can be broken or unevenly divided, errors implicated in the uncontrolled cell division of cancer.

One tragic feature of osteosarcoma is the rapid, error - prone production of weaker bone by cancerous bone - making cells, where a young person surprisingly breaks a bone to reveal undiagnosed, advanced cancer.

Then, they showed that when the cancer cells didn't make enough ATRX, the cells couldn't join together the two ends of a broken DNA strand.

«We found that these new - generation paradox - breaking BRAF inhibitors did not promote or accelerate the growth in the colorectal cancer cells and may therefore, pending the results from ongoing clinical trials, be a safer alternative to be used alone or in combination in melanoma patients,» Dr Behren said.

A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.

Dr Behren said the «paradox breaking» compounds were tested on BRAF melanoma cells for their potential to inhibit their growth and, after being seen to successfully target these cells, were then tested for their growth - promoting effects on various colorectal cancer cells in comparison to the classical drugs.

The cancer cells placed protective membrane «sacks» round cell waste, and filled them with chemicals to break up and recycle the contents.

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits Repair of Interstrand DNA Crosslink, enhances DNA Double - strand Break, and sensitizes Cancer Cells to Cisplatin.