Sentences with phrase «cancer cells control»

Not exact matches

As a physics teacher, I teach the therapeutic effects of gamma radiation in radiotherapy, along with the associated dangers (radiation can cause cells to become cancerous as well as kill cells that are already cancerous), but a common misconception among students is that cancer cells are rather like viruses or bacteria, a sort of alien cell that has entered the body, growing out of control with little relation to the surrounding cells.

Researchers studied food questionnaires for 335 people with renal cell carcinoma, the most common form of kidney cancer, and 337 healthy controls.

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrated.

A type of immune therapy known as PD - 1 blockade controlled cancer in 77 percent of patients with defects in DNA mismatch repair — the system cells use to spell - check and fix errors in DNA (SN Online: 10/7/15).

A protein called YAP1 was previously shown to contribute to the growth of lung cancer cells; however, it was unknown how YAP1 controls lung cancer growth and progression.

The idea to specifically study this group of patients was based on groundbreaking research Garon published in the New England Journal of Medicine last year, which found that among patients who received pembrolizumab, those with PD - L1 expression on at least 50 percent of their cancer cells showed the longest survival and disease control.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

However, for patients with lymphoma, it may be a rather different story, as new research from the University of Copenhagen shows that toxins in the staphylococcus bacteria help cancer cells gain control over healthy cells.

One of the hallmarks of cancer cells is they don't experience apoptosis and keep dividing out of control.

In cancer cells, the protein networks that control the behavior are changed in such a way as to cause the cells to lose control and break away — a mutated skin cell, for instance, might then migrate into the bloodstream.

The scientists hope their findings on cell migration in zebrafish will open up new perspectives for research on proteins that control metastasis and thus the malignancy of cancer.

Daniel Chen, a postdoc in Dogic's lab, imagines that someday the droplets could be controlled to deliver drugs or seek out cancer cells.

Using immunostaining, the researchers counted the remaining tumor cells; the mice treated with GD2 CAR - T cells had a few dozen remaining cancer cells per animal, while each control mouse had tens of thousands of cancer cells.

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

«We have identified a code of «molecular switches» that control a very aggressive subpopulation of brain cancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell arcancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell arCancer Research, co-lead author of the Cell article.

When injected with cancer cells, animals housed there developed tumors 80 % smaller than those in control mice, or no tumors at all.

«In pancreatic, ovarian and liver cancers, we hope that by adding anti-cancer stem cell drugs to standard of care, we can control proliferating cells within the tumor that could otherwise help the tumor regenerate in the face of existing chemotherapies.»

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

But the researchers also found that the new molecule intervened directly in the growth of the cancer itself, inhibiting a protein that controls the division and proliferation of malignant cells.

(D) When accounting for the reduced efficiency in adherence, the cancer cells display a similar inefficiency in their ability in invade through the collagen of irradiated matrices relative to controls.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

«A general message from these studies is that cancer cells benefit from modulating epigenetic factors like SIRT6 by acquiring the ability to override normal cellular growth control patterns,» says Mostoslavsky, an associate professor of Medicine at Harvard Medical School and an associate member at the Broad Institute.

Surprisingly, the cancer - promoting program that RB - loss unleashed was distinct from the cell - cycle control genes that RB is best known for controlling.

By providing a woman's family history of these cancers, including the ages they were diagnosed, the programs calculate a probability that the patient carries a harmful mutation in BRCA1 or BRCA2 (genes involved in controlling malignant cell growth).

Once stem cells can be grown and differentiated in a controlled way to replace degenerated cells and repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.

But sometimes things went wrong, cells multiplied out of control, and the result was cancer.

In contrast, viruses that cause cancer, such as the human papillomavirus that is responsible for most cases of cervical cancer, disrupt a cell's genome, thereby triggering out - of - control growth.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

The runaway replication of cancer cells can also traced to genetic causes — mutations that remove the normal controls on cell growth.

His hunch is that the mechanisms controlling cell division have gone wrong — somewhat like what happens in cancer — and that plaques and tangles are the result.

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol - lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

Many cancers take control of regulatory T cells to suppress the immune system, creating an environment where tumors can grow without being detected.

While cancer cells are immortal — their hallmark is wildly reproducing out of control — Hayflick discovered that normal cells have a limited life span.

Experiments showed that HIFs controlled the production of GSTO1 in breast cancer cells when they were exposed to chemotherapy; if HIF activity was blocked in these lab - grown cells, GSTO1 was not produced.

Klingelhutz and his team immortalized immature precursor fat cells by adding in two genes from HPV (the virus that causes cervical cancer) along with a gene for part of an enzyme that controls the length of cells» telomeres — the pieces of DNA that protect chromosome tips from deterioration.

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasicancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer MetastasiCancer Metastasis Lab.

Moffitt Cancer Center researchers have discovered a novel mechanism that controls a cell's response to DNA damage.

The study, «VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer» found that novel non-coding parts of the human genome known as vlincRNAs (very long intergenic, non-coding RNAs) triggered by ancient viruses, participate in the biology of stem cells, and in the development of cancer.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.

Analyzing white blood cells from 934 patients and 1,698 healthy controls, they found BRCA1 methylation among 6.4 % of patients diagnosed with ovarian cancer, contrasting 4.2 % among controls.

In these vesicles, we saw the EGFR and HER2 receptors being broken down, but we also saw our negative control receptor, c - MET,» said Dent, who is the Universal Corporation Chair in Cancer Cell Signaling and a member of the Cancer Cell Signaling research program at Massey.

«Potentially reversible changes in gene control «prime» pancreatic cancer cells to spread: Epigenetic changes, not DNA mutations, drive some metastasis.»

FOXO was normally thought of as the «good guy» molecule that controls cancerous cell growth, while c - Myc, the cancer - promoting molecule, the «bad guy.»

The drug, lapatinib, activates the suppressor called FOXO, in HER2 + breast cancer cells, but then FOXO becomes a turncoat molecule, working with an epigenetic regulator that controls gene expression.

The finding could reveal much about how cells control gene activity, and also illuminate cancer, multiple sclerosis, and other diseases spurred by faulty gene expression.

Professor Aoki says, «By controlling the intercellular transmission of ERK activity in the future, it may be possible to suppress the infiltration of cancer cells.»

The immune system is not only responsible for controlling infections, but also for recognizing and destroying cancer cells.