Sentences with phrase «cancer cells express»

There is evidence that hyperinsulinaemia, hyperglycaemia and chronic inflammation may affect the neoplastic process through various pathways, including the insulin / IGF -1 pathway, and most cancer cells express insulin and IGF - 1 receptors.

Studies show that human cancer cells express high levels of the fatty acid synthase enzyme, which is associated with aggressive tumor behavior and tumor - cell growth.

In addition, many cancer cells express insulin receptors (IRs) and show hyperactivation of the IGF1R - IR pathway.

However, examining OS tumours the research team behind the new results found that OS cancer cells express special enzymes and receptors, enabling them to degrade bone tissue themselves.

CAR - Ts also have their limitations; they target specific proteins, but not all cancer cells express these and some healthy ones may.

The team has identified that aggressively spreading cancer cells express a protein called Myosin - 10 which drives cancer cell motility.

Cervical cancer cells expressing a wound - healing signal (green) in response to TRAIL stimulation.

Neil Johnson's lab at the Fox Chase Cancer Center examined treatment resistance in breast cancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatments.

«Our work also suggests that cancer cells expressing high levels of BOK may be particularly sensitive to inhibitors that target the proteasome or the ERAD pathway.»

An initial payload of CD8 cells breaks down the tumor, and the HSC - derived CD4 cleans up the remaining cells and acts as protection against the recurrence of any cancer cells expressing NY - ESO - 1.

TAZ protein abundance was not decreased by GNF5 treatment in breast cancer cells expressing murine Abl2 - E505K, a mutant that is resistant to the GNF5 allosteric inhibitor (fig.

Not exact matches

Because prostate cancer does not express SLC13A5, the growth of prostate cancer cells was unaffected by suppressing SLC13A5 expression.

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

«We think that these genes, which are normally only expressed in the placenta to facilitate invasion, are becoming reactivated in cancer cells and supporting invasion in this context too,» she says.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

In the GD2 CAR - T treated animals, the residual cancer cells did not express GD2, suggesting that these remaining cells were not vulnerable to the immune therapy and might be able to cause the cancer to recur.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

«We have been able to show that this protein is highly expressed in metastatic triple - negative breast cancer, and when we are depleting it from triple - negative breast cancer cells, we found that the cancer cells are not metastasizing,» Dr. Paul said.

They found that atypical protein kinase c lambda / iota, which is known to influence cell growth, was highly expressed and phosphorylated in metastatic breast cancers.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

The group looked at an oncogene, AF1q discovered in Tse's lab, which is expressed in hematological cancer cells and is known to be related to multiple myeloma.

In 1994, scientists first realized that putting the EGFP gene into cells made them glow green, making it possible to easily visualize them: ever since, scientists have generated thousands of living systems with EGFP, including EGFP - expressing viruses and EGFP - expressing cancer cells.

However, this coupling does not exist in cell culture models with exogenously expressed c - MYC — the type of systems that are mainly used to investigate glutamine addiction in cancer.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

They compared the global proteome (all of the expressed proteins) of Ras - driven cancer cells where autophagy was present to those where autophagy was deficient.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

As different cancers express different biomarkers, it might be possible to modify the molecular structure of the ruthenium molecule to target different types of cancer cell.»

In this study, researchers compared the effectiveness of the immunotherapy drug nivolumab (pronounced «nye VOL ue mab,» marketed at Opdivo), with standard - of - care chemotherapy in 541 patients with previously untreated or recurrent non-small cell lung cancer (NSCLC) that expressed PDL - 1 antibodies.

Wellcome Trust Sanger Institute scientists and their collaborators have developed a new analysis tool that was able to show, for the first time, which genes were expressed by individual cells in different genetic versions of a benign blood cancer.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

They found that the number of copies of lncRNA genes on a chromosome consistently change in 12 different cancer types and lncRNA genes are widely expressed in cancer cells.

More importantly, the fibronectin part of the complex is expressed during a cell's transition to cancer and plays a role in cell growth, migration and differentiation.

This capability allowed the researchers to maneuver the nanospears in a lab dish to modify brain cancer cells so that they expressed a green fluorescent protein.

After being infused back into patients» bodies, these newly built cells both multiply and seek out a peptide expressed by the antigens NY - ESO - 1 and LAGE - 1 found in multiple myeloma cancer cells.

In one experiment, the researchers created arrays of mammary epithelial cells and asked how adding one or more cells expressing low levels of the cancer gene RasG12V affected the cells around them.

Next, the researchers tested the effects of RK - 33 and radiation in mice that had been injected with human prostate cancer cells that highly express DDX3.

High - resolution microscope image of an invasive breast cancer cell (magenta) expressing Myosin - 10 induced «sticky - fingers» (green).

What's more, the disrupted circadian oscillations in the MYC - expressing cancer cells could be partially rescued by inhibiting expression of REV - ERBα.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

At Gritstone Oncology, researchers pair deep learning with multi-omic profiling to characterize a patient's cancer and identify unique antigens that aren't expressed by healthy cells.

At the Dana - Farber Cancer Institute and the Broad Institute, for instance, Todd Golub, a specialist in the genetics of cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their Cancer Institute and the Broad Institute, for instance, Todd Golub, a specialist in the genetics of cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their cells.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

«There was some skepticism about whether a CD19 - directed therapy would work in this disease, since nearly all of these patients» cancerous plasma cells do not express CD19,» said the study's senior author, Edward Stadtmauer, MD, chief of Hematologic Malignancies and a professor of Hematology / Oncology in Penn's Abramson Cancer Center and Perelman School of Medicine.

«The study represents a clear breakthrough in precision medicine, as this molecule only kills the cancer cells that express the cancer - causing gene — not healthy cells.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.