Sentences with phrase «cancer cells from each patient»

When Fishel and Kolodner heard of the accumulation of mutations in cancer cells from patients with familial colon cancer, they suspected that the gene responsible would be similar to the bacterial and yeast genes they had studied.

By matching normal and cancer cells from a patient, we can now study the differences — what molecules are key to tumor development and growth, and, ultimately, match treatments that might disable this cancer,» says the study's senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the Center for Cell Reprogramming (CCR) at Georgetown University Medical Center.

Not exact matches

Consider: Last year alone, the FDA approved two treatments, from Novartis and Gilead, that literally reengineer patients» immune T - cells to target and destroy blood cancers.

Researchers from the Sichuan University in Chengdu inserted the re-engineered cells into a lung cancer patient participating in a clinical trial at the West China Hospital on October 28th, according to Nature.

Speaking of Novartis — the company's experimental CTL019, which is expected to be the first approved drug in a revolutionary new cancer treatment space that turns the body's own immune cells into cancer - killers, is already facing some apprehension from doctors and patient groups who are worried about its eventual pricing.

This new kind of approach to fighting blood cancers is truly personalized; immune T - cells are extracted from patients, genetically tinkered to home in on an destroy cancerous cells, multiplied in a lab, and then jolted back into the patient's body within about two weeks.

Lab - grown tissues derived from patients» stem cells may also allow researchers to screen drugs and test their effectiveness on diseases like cancer.

And using cells from someone other than the cancer patient being treated might trigger an immune response against the foreign cells.

In the March 22 online issue of Cancer Research, scientists explained how they injected triple negative breast cancer stem cells from patients intoCancer Research, scientists explained how they injected triple negative breast cancer stem cells from patients intocancer stem cells from patients into mice.

They also determined that blocking the enzyme reduces multiple myeloma regeneration in experimental models derived from patient cancer cells.

However, for patients with lymphoma, it may be a rather different story, as new research from the University of Copenhagen shows that toxins in the staphylococcus bacteria help cancer cells gain control over healthy cells.

The study also suggests that targeting the machinery that makes cells mobile, rather than targeting the tissue - clearing process — which has been tested in patients but has not been very effective — may be a better treatment strategy to stop cancers from spreading.

Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Rescancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer ResCancer Discovery, a journal of the American Association for Cancer ResCancer Research.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

The results of the empirical study show a clear distinction between the damage to the white blood cells from patients with cancer, with pre-cancerous conditions and from healthy patients.

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

«If you give patients immune cells to eradicate any remaining cancer cells that might be present,» he says, «those immune cells would not be prevented from doing their job by ongoing immune suppression drugs that are being used in patients treated with conventional transplant approaches.»

From a simple blood draw, the test reads the DNA of the patient's immune repertoire to find the immune cell barcodes associated with the cancer.

By promoting DNA demethylation, high - dose vitamin C treatment induced stem cells to mature, and also suppressed the growth of leukemia cancer stem cells from human patients implanted in mice.

Pre-clinical studies have shown it to be effective in eliminating a number of different kinds of cancers cells, including cancer stem cells from human breast cancer patient biopsies.

Fat cells cultured from the body mass index of a morbidly obese patient cause multiple myeloma cells to anchor to a much greater extent than normal cells and produce a significantly larger number of blood vessels to sustain the cancer cells.

Dr. Jochen Maurer and his research group were able to cultivate several cancer stem cell lines from triple receptor - negative breast cancer that are excellent representations of the original tumors they isolated from the patients.

The researchers isolated bacteria from the tumors of pancreatic cancer patients and tested how they affect the sensitivity of pancreatic cancer cells to gemcitabine, a chemotherapy drug.

Patricia McGowan of University College Dublin, Ireland, treated triple - negative cells taken from seven patients with a compound that inhibits receptors important for the cell division and spread of this form of cancer.

Whether investigating fat cells, immunotherapy or use of the CRISPR - Cas 9 gene - editing tool, which a federal panel recently approved for a select number of patients suffering from three types of cancers, including multiple myeloma, approaches beyond attacking cancer cells are needed in the fight against many cancers.

Shown here is a cluster of circulating tumor cells (red) from a patient with breast cancer.

Porter and June are now participating in a new trial, funded by the National Cancer Institute, that will administer about a dozen patients a fifty - fifty mixture of cells from the Penn and Sloan - Kettering groups.

He then evaluated the levels of specific microRNAs in populations of highly metastatic, compared to poorly metastatic, cancer cells taken from the same patient.

In this study, researchers took cells from patients with blood cancer MDS and turned them into stem cells to study the deletions of human chromosome 7 often associated with this disease.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Until recently, Ain was renowned for a highly prized repository of 18 immortal cancer cell lines, which he developed by harvesting tissue from his patients» tumors after removal, carefully culturing them to everlasting life in vials.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

They found out that TiY is capable of distinguishing TICs from non-TICs in various human lung cancer cell lines and patient - derived lung tumors.

Using tumor samples from a patient, they do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.

By assessing the survival of the cells that engulf the particles and measuring the levels of red or green light that they emitted, the researchers determined which formulation of particles performed best, then tested that formulation in mice with human brain cancer derived from their patients.

The initial experiments made use of cancer cells that Quiñones - Hinojosa and his team removed from willing patients and grew in the laboratory until they formed little spheres of cells, termed oncospheres, likely to be the most resistant to chemotherapy and radiation, and capable of creating new tumors.

Now a team of researchers in China has developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood, with potential applications for cancer screenings and treatment assessments.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol - lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.

This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype.

Apart from patient testimonials and a few preliminary studies in tumor cell lines and in mice, critics say, there is no evidence of the safety or efficacy of the compound, popularly known as the «cancer pill» or «fosfo.»

«FDG PET shows tumor DNA levels in blood are linked to NSCLC aggressiveness: Insights derived from FDG PET could improve treatment selection for patients with advanced non-small cell lung cancer.»

To make the vaccine, cancer cells are harvested from a tumor after surgery and stripped of their proteins; then those proteins are cultured with dendritic cells, a subclass of white blood cells, drawn from the patient's blood.

He did, however, publish a paper last year documenting a study in which he infused three cancer patients with white blood cells from young donors who had been injected with G - CSF.

A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

Fine got federal approval this year to try such a drug screen on one patient whom he describes as «well - connected,» creating an organoid from her cells and adding bits of her tumor to it in hopes of throwing drug after drug at it until one vanquished the organoid's cancer.

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

Nana - Sinkam and his colleagues examined lung - tumor samples from 81 patients with stage - 1 nonsmall - cell lung cancer and tumor - cell lines.