Sentences with phrase «cancer cells infected»

D, the same primary breast cancer cells infected with KLF4 or control lentivirus were cultured in low - attachment plates and the number of mammospheres was counted after 10 days.

That was the first report of such contagious cancer cells infecting a new species.

Not exact matches

An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer.

These don't normally integrate into the genome of cells that they infect and therefore present little risk of cancer.

To address this gap in knowledge, Mirabello and Schiffman teamed up with co-senior author Robert Burk of Albert Einstein College of Medicine to sequence the whole genomes of 5,570 HPV16 - infected cell and tissue samples from women around the world and to identify associations between HPV16 genetic variants and the risk of cervical precancer and cancer.

They lack the ability to infect cancer cells and therefore can not inject the genetic blueprints for the therapeutic molecules to fight the disease.

But this ability to infect brain stem cells may prove useful for fighting deadly brain cancers, many of which are caused by mutated stem cells.

Developed by Amgen, it uses a modified version of the herpes virus that can't infect healthy tissue but attacks cancer cells.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

Dr. Cripe and his colleagues at The Ohio State University, the University of Pittsburgh School of Medicine and Cincinnati Children's Hospital Medical Center tested how well the oncolytic viral therapy — a cancer - killing form of the herpes simplex virus, called oHSV — infected and killed tumor cells in mice with and without a healthy immune system.

The second challenge to researching viral therapies for childhood cancers is the fact that mouse cells don't get infected with human viruses as easily as human cells.

However, some human tumor cells may also be hard to infect with viral therapies, Dr. Cripe reasoned, and knowing how cells respond in those situations could also be important to improving cancer treatments.

Epigenetic therapies are thought to work in two ways to fix these errors in cancer cells — by correcting the «position» of the gene switches and by making the cell appear as though it's infected by a virus, triggering the immune system.

Many clinical trials combine virotherapy with chemotherapy or other immunosuppressive agents to try to allow the virus to survive and infect as many cancer cells as possible.

But infected cells can reach such high numbers that the progression to cancer is not terminated by the many mutations that kill the cells or make them nonfunctional.

He is using the virus to cure a rare form of blood cancer called EBV lymphoma, caused when B lymphocyte immune cells get infected with the Epstein - Barr virus (EBV).

The company says the reovirus selectively infects cancer cells over healthy ones because once a cell turns malignant it stops making an antiviral factor called protein kinase R.

Next, T cells — the immune system's foot soldiers — are harvested from the patient's blood and infected with the virus, which rewrites their genetic code to recognize and destroy cancer cells.

«They are paralyzed and don't have the fire - power to destroy cancer or virally - infected cells.

These cells are highly specialized guardians of the immune system and their role is to kill cells infected by a virus, damaged cells, or cancer cells.

«How the virus infects and replicates has a direct influence on how the cell becomes a cancer cell,» Gao said, adding that you can not cure cancer without some kind of roadmap.

But while researchers have previously been able to infect cultures of human hepatocytes with HBV, the cells» limited lifespan has made it difficult to study the virus, says Bhatia, who is also a Howard Hughes Medical Institute investigator and a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.

«Infected Tasmanian devils reveal how cancer cells evolve in response to humans.»

«In people chronically infected with hepatitis B or C, human papillomaviruses or other viruses known to cause cancer, radioimmunotherapy could potentially eliminate virus - infected cells before they're able to transform into cancer cells.»

In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapy.

«New research helps explain why a deadly blood cancer often affects children with malaria: Immune responses to malaria - infected red blood cells appear to sometimes lead to cancer - promoting changes.»

First, the viruses infect and kill cancer cells.

Doctors in France have found the first evidence that a cancer drug may be able to eradicate HIV - infected cells in humans.

Viral agents then burst out of the stem cells, infecting the cancer tissue — but leaving healthy brain tissue alone.

Both strains spread through the tumors, infecting and killing the cancer stem cells while largely avoiding other tumor cells.

Genome studies show that several such viruses, including one that infects mouse mammary cells and has been linked to cancer, have something in common — a sequence of DNA similar to that found in immune system cells.

Led by Ludwig Lausanne investigator Alexandre Harari and George Coukos, director of the Ludwig Institute for Cancer Research, Lausanne, the study shows that ovarian tumors harbor highly reactive killer T cells — which kill infected and cancerous cells — and demonstrates how they can be identified and selectively grown for use in personalized, cell - based immunotherapies.

But the barrier also prevents treatments — like cancer drugs — from reaching infected cells, limiting options for patients.

«It gives credence to the concept that like cancer cells, HIV - infected cells can be targeted and eliminated by a drug.»

«Since MCR works by targeting specific DNA sequences, in cases where diseased cells have altered DNA as in HIV - infected individuals or some types of cancer, MCR - based methods should be able to distinguish diseased from healthy cells and then be used to selectively either destroy or modify the diseased cells.»

C, primary breast cancer cells isolated from patients with advanced cancer were directly infected with KLF4 or control lentivirus, and the CSC population (CD24 − CD44 + ESA +) was measured by FACS after culturing the cells for 72 hours in low - attachment plates.

CTLs can destroy cancer cells and cells infected with viruses, fungi, or certain bacteria.

In addition, consistent with past studies, AAV2 - infected cancer cells produced more Ki - 67, an immunity system activating protein and c - Myc, a protein that helps both to increase cell growth and induce apoptosis.

The body, in return, produces an immune response that attacks virally infected cervical cancer cells.

It's not a germ that infects them but a sickening cell — a cancer cell — from a member of their own species.

One of its key cells is known as the Natural Killer (NK) cells, which identify and eliminate those cells that are infected with viruses or transformed by cancer.

The Pexa - Vec virus was originally developed by Michael Mastrangelo, MD, and Edmund Lattime, PhD, of Thomas Jefferson University in Philadelphia, who engineered the harmless vaccinia virus to infect only cancer cells and other rapidly dividing cells, as well as to stimulate immune activity, in hopes of boosting the immune response to tumors.

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

A new UC San Francisco study has shown that a cancer - killing («oncolytic») virus currently in clinical trials may function as a cancer vaccine — in addition to killing some cancer cells directly, the virus alerts the immune system to the presence of a tumor, triggering a powerful, widespread immune response that kills cancer cells far outside the virus - infected region.

From there they showed that cancer cells had lost structural polarity, resulting in random distribution of CAR receptors on their surface, thereby allowing the virus to attach to and infect the tumor cells.

This protects the normal, healthy cells from being infected, while still allowing the virus to work against cancer cells.

These observations lent additional support for the premise of prostate cancer tissue contamination by XMRV - infected LNCaP, and not 22Rv1, cells.

In 2011, Paprotka, et al. reported that XMRV likely originated through recombination between 2 endogenous murine retroviruses, PreXMRV - 1 and PreXMRV - 2, during in vivo passaging of the human prostate cancer xenograft CWR - R1, resulting in establishment of the XMRV - infected 22Rv1 cell line [38].

To prove the hypothesis that an XMRV - infected cell line had contaminated the prostate cancer samples in the 2006 Urisman, et al. study, we analyzed available RNA extracts using a novel technique referred to as mitochondrial RNA (mtRNA) profiling.

Natural Killer cells patrol the body and detect characteristic alterations on the surface of cancer cells or virus - infected cells.