Sentences with phrase «cancer cells involve»

Growth inhibition induced by antiprogestins RU - 38486, ORG - 31710, and CDB - 2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.

Not exact matches

Basically, CAR - T therapy involves taking a patient's own immune «killer» T - cells, inserting new genetic code into those cells which turn them into cancer - hunters that can home in on malignant B - cells (another kind of immune cell), and then pumping these specialized leukemia - busting cells back into the patient.

Cancer - focused CRISPR technology involves taking a set of molecular shears and the guiding molecule Cas9 in order to cut out unwanted genes in immune cells that may help proliferate cancers.

In clinical trials the treatment — which involves extracting individual patients» immune T - cells, modifying them to seek out tell - tale biological markers associated with blood cancers like aggressive lymphoma, and then pumping those modified killer cells back into the body — has shown major promise, in some cases eliminating all signs of the cancer in patients six months after treatment.

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

The novel treatment space involves transforming a patient's own immune T - cells into cancer - busting weapons.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

It's the second approval for this pioneering approach to cancer treatment, which involves re-engineering patients» own immune cells to become cancer killers, after the FDA's approval of Novartis» Kymriah in August.

Overcoming the immense logistical challenges involved with withdrawing, shipping, modifying, returning, then reinfusing cells for every patient treated paints a scary question mark on the future of cell - based cancer therapies.

CAR - T approaches involve reengineering T - cells to find and destroy cancer cells, but that process can cause cytokine release syndrome (CRS), a life - threatening immune response NantKwest hopes to sidestep.

Metastasis involves clumps of cancer cells becoming detached and moving through the blood stream or the lymphatic system to other areas, where they become attached to a new site and continue growing.

Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor Cancer: Flaxseed may protect against breast cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cancer, prostate cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cancer, and colon cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cancer by inhibiting tumor growth and blocking enzymes that are involved in the spread of tumor cells.

Treatment typically involves chemotherapy (using chemicals intravenously to kill cancer cells), radiation therapy (using high - powered X-rays to kill cancer cells), or surgery to remove the breast and surrounding lymph nodes.

She demonstrated that early experience leads to lasting changes in the molecular structure of the brain and discovered a gene involved in the spread of brain cancer cells into healthy brain tissue.

Non — small cell lung cancer may involve genetic aberrations that can be used to direct therapy.

Lewis is now skimming through these genes to check their function; of those he's looked at so far, several are involved in growth and development, cell differentiation, cell death, and protecting against cancer.

The team led by Andreas Plückthun, Director of the Department of Biochemistry at the University of Zurich, involving postdoc Rastik Tamaskovic and PhD student Martin Schwill, has now found out why these antibodies merely slow tumor growth rather than killing off the cancer cells.

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

Moreno also found a homologue of a human cancer gene involved in cell competition.

Non-melanoma skin cancers — specifically, basal cell carcinoma and squamous cell carcinoma — are more likely than melanoma to involve itch or pain, the study found.

Therefore, a novel therapeutic approach in inflammatory breast cancer could involve a combination of conventional chemotherapy with small - molecule inhibitors of the Cdk2 cell cycle kinase.

«Our work suggests a mechanism for cell lethality involving the regulation of BCAAs as crucial elements in pancreatic cancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD Andcancer by regulating ME3,» said Ronald DePinho, M.D., professor of Cancer Biology, senior author of the Nature paper and president of MD AndCancer Biology, senior author of the Nature paper and president of MD Anderson.

The theory that cancer progression involves the acquisition by tumor cells of features similar to those of stem cells has gained strength in the scientific community.

These progenitor cells are often drug resistant and can initiate cancer development and are possibly involved in cancer relapse.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cCancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancercancer.

By providing a woman's family history of these cancers, including the ages they were diagnosed, the programs calculate a probability that the patient carries a harmful mutation in BRCA1 or BRCA2 (genes involved in controlling malignant cell growth).

If a breast cancer line had silently contaminated Klonisch's cell culture early on, it would have been subject to the usual technique for immortalizing a normal cell (which involves applying enzymes, antibiotics and antibiotic - resistant genes).

But Pearse had shown that no virus was involved; the cancer cells had transferred directly from one animal to the next.

Óscar Llorca and his team have used this technique to learn about the structure and functioning of a complex system called R2TP, which is involved in various key processes for cell survival such as the activation of the kinases mTOR, ATR and ATM, proteins that are the target of various cancer drugs currently being developed.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

The study involved 23 patients with relapsed or treatment - resistant HL, a cancer of white blood cells called lymphocytes.

Finding out involves passing a sample of blood through a microfluidic device, in whose tiny channels cancer cells can be captured and identified.

The IFNGR receptor is one of these membrane proteins and undertakes to activate genes involved in a huge variety of cell processes, including defence against pathogens and cancer.

Many genes that are involved in the growth and development of embryos or adult stem cells also play roles in cancer, Resar adds.

The researchers also want to see what other proteins and mRNAs are involved in the relationship, and why some cancer cell lines they tested did not show the same increased ALKBH5 levels in response to low oxygen levels.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

This complex is involved in regulating the cell replication cycle, which becomes dysregulated in cancer.

Diagnosing cancer today usually involves various imaging techniques, examining tissue samples under a microscope, or testing cells for proteins or genetic material.

Such cell - tracing techniques are the right approach to test the cancer stem cell model, says Sean Morrison, who studies stem cells and cancer at UTSMC and who was not involved in any of the studies.

The current research involved acute lymphoblastic leukemia (ALL) cells, a common type of childhood cancer.

Studying breast and brain cancer cells in a hypoxia incubator, Uniacke and his team discovered that cadherin - 22 is involved in this process to enable the spread of cancer cells.

«The research, which involved one of the most common childhood cancers, shows that the cancer cells were eliminated.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

New results from a clinical trial involving more than 900 military veterans at high risk for keratinocyte carcinoma skin cancer provides evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75 percent within a year.

The team is now working with doctors at Massachusetts General Hospital, who hope to use the new, noninvasive technique to study cells involved in cancer, asthma, and other conditions in which cell properties change as a disease progresses.

A similar idea involves injecting cancer patients with strains of different bacteria that have been genetically modified to present antigens found on pancreatic cancer cells.

Because AML is difficult to treat, standard treatment commonly involves multiple chemotherapy medicines that are given at a higher dose in order to kill the cancer cells.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing ceCell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cecell division — prevents cellular proliferation of rapidly dividing cells.