Sentences with phrase «cancer cells properties»

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Not exact matches

Elsewhere, Philip Ball, an English science writer, reports on research into the mechanical properties of cancer cells.

Goji's are reported to have anti-aging properties and show anti-tumor activities against various types of skin cancer cells by inhibiting tumor growth and inducing apoptosis.

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrated.

To hunt for drugs that target these cells, Piyush Gupta, a molecular biologist at the Broad Institute at the Massachusetts Institute of Technology, and colleagues genetically engineered ordinary human cells so that they acquired some of the properties of cancer stem cells, including being impervious to chemotherapy.

Previous work from Shenoy's group has shown that the relationship between cancer cells and the extracellular matrix is dynamic, containing feedback mechanisms that can change the ECM's properties, including overall stiffness.

«With this discovery in our hands, we'd now like to try to find out which additional immune - cell properties cancer cells have and study how they affect the metastatic process,» says Dr Fuxe.

Beales and co-senior study author João Ruggiero Neto of São Paulo State University in Brazil suspected that the reason might have something to do with the unique properties of cancer cell membranes.

Within that sting lies a peptide called chlorotoxin, which has an unusual property — it sticks strongly to tumour cells while ignoring surrounding healthy tissue, by binding to a cancer - specific protein called matrix metalloproteinase - 2.

Now, a new study adds another twist to the story: It argues that two commonly prescribed diabetes drugs with antioxidant properties also spur metastasis, at least in cancer cells and mice.

Their stem cell - like properties enable them to maintain a pool of cancer stem cells within the tumor, as well as to produce new mature tumor cells.

Given their similar profiles, Seyedsayamdost and coworkers hypothesized that TDA might exhibit anticancer properties as well, and indeed observed its strong anticancer activity in a screen against 60 different cancer cell lines.

But the cells also changed shape and other properties in the absence of the protein in ways that reduced the likelihood that they would travel away from the tumor — a sign that myoferlin not only changes genes in cancer cells, but also alters the cells» mechanical properties.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

The team is now working with doctors at Massachusetts General Hospital, who hope to use the new, noninvasive technique to study cells involved in cancer, asthma, and other conditions in which cell properties change as a disease progresses.

He is researching the functions and properties of human sulfotransferase (EST) enzymes in human breast cancer cell lines.

«One of the challenges of current cancer therapies, including new targeted therapies, is a cancer cell's ability to overcome a treatment's anticancer properties.

In order to identify the cancer stem cells from other cells in the tumor, the research team studied epigenetic mechanisms that distinguish between the least - sorted cells, with endless division properties and a potential to create growth, and the more sorted cells which lack this ability.

The researchers identified the LSC17 score by sampling the leukemia stem cell properties of blood or bone marrow samples from 78 AML patients from the cancer centre combined with molecular profiling technology that measures gene expression.

When cancer develops, the generated cells are not uniform in their biological properties and contribute differently to tumor development.

Moffitt researchers wanted to determine if it would be possible to activate the cancer - fighting properties of T cells indirectly by targeting another type of immune cell called a dendritic cell.

«This study provides evidence that CA125 - negative high - grade serous ovarian cancer cells have stem properties and are inherently platinum resistant.

The adhesive properties of cancer cells play a key role in the formation and development of a tumour.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

«In addition, although many shared properties exist between infection and cancer, future studies identifying distinct regulatory wiring in cancer - infiltrating T cells are essential for the continued progress of cancer immunotherapy.»

And we have a potential target to be able to influence that activity to change the properties of cancer cells,» says Professor Richards.

Cédric Blanpain, MD / PhD, professor and WELBIO investigator at the IRIBHM, Université libre de Bruxelles, Belgium, report that Sox9, directly controls skin cancer formation by regulating the expansion of tumor initiating cells and the invasive properties of cancer cells.

Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human breast cancer cells to take on aggressive, metastatic properties.

Altered promoters in GC change the gene expression profile of GC cells and may confer its oncogenic properties, including cell movement and cancer signalling.

We can use those chemicals to thwart the cancer cells» ability to harness the properties of HSF1.

The aggressiveness of a tumor is determined partly by the properties of the actual cancer cells, but also to a surprisingly large degree by the surrounding envi...

Juan R. Cubillos - Ruiz, Ph.D., a 2012 - 2014 CRI postdoctoral fellow at Weill Cornell Medical College, is working to understand how dendritic cells (DCs), immune cells responsible for activating and «training» other immune cells, acquire pro-tumor properties in ovarian cancer.

Both microRNA families have the connection to drug resistance as well as to cancer stem cells, sub-population of cancer cells that have self - renewal properties and the ability to give rise to new tumors that are more resistant to current therapy.

Sphere - forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines.

Besides their stem cell properties, CSCs have become a focus of pharmacological studies due to their resistance to many cancer therapies.

Cancer cells have altered membrane properties that hamper their ability to take up nanomedicines.

Structural analogues with similar binding properties may also be active against HIV infection, cancer cell migration, and inflammatory disorders mediated by CXCR4.

Tie - 2 regulates the stemness and metastatic properties of prostate cancer cells.

Currently, her research interest is focused on the functional characterization of cell - autonomous molecular determinants, known to control cardinal stem cell properties in normal NSCs, in the attempt of understanding their putative role in regulating the same properties in brain tumor - derived cancer stem cells.

FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer types as well.

This has allowed investigation of the mechanical properties of cells, which, according to some research studies, could have applications in medicine, for example by enabling cancer cells to be distinguished from healthy ones.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Our results led us to speculate that there might be a metastatic subpopulation within stem - like cancer cells since other studies have shown that CSC phenotype alone may exhibit invasive property in vitro but is inadequate to determine or predict in vivo metastasis.

Stem cells and their tumorigenic alter egos cancer stem cells (CSCs) share many key properties, although CSCs are also posited to promote tumour growth, evolution, and drug resistance [1].

Cells in a tumor or tissue can change their own mechanical properties in often complex ways, using genetic programs and other feedback loops, and if jamming is to provide a solid conceptual foundation for aspects of cancer, it will need to account for this ability.

Epithelial - mesenchymal transition (EMT) contributes to the progression of cancer through enhanced invasion and stem - like properties of cancer cells.

Stem Cells Make Bone Marrow Cancer Resistant to Treatment Scientists at the Johns Hopkins Kimmel Cancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatmCells Make Bone Marrow Cancer Resistant to Treatment Scientists at the Johns Hopkins Kimmel Cancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatCancer Resistant to Treatment Scientists at the Johns Hopkins Kimmel Cancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatCancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatcancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatmcells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatmcells and have multiple ways of resisting chemotherapy and other treatments.

Although cancer stem cells have been identified in many different types of cancer, it is becoming increasingly clear that the properties of these cells may vary greatly among the different tumor types.

We also observed inhibition of triple negative breast cancer cells, HCT1143 and MDA - MB231, with RIPK2 inhibitor 1 (Supplemental Fig. 4B), suggesting effective antiproliferative properties.