Sentences with phrase «cancer cells reprogram»

Not exact matches

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

We're entering a new frontier in medical innovation with the ability to reprogram a patient's own cells to attack a deadly cancer.

Eventually, Lim hopes that reprogrammed cells will measure glucose levels in the pancreases of diabetics and trigger a biological insulin response, or even cure cancer.

As melanoma develops, these cells are eventually reprogrammed, lose their differentiated features and become invasive, migratory cancer cells.

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

For the first time, specialised cells have been reprogrammed into the equivalent of embryonic stem cells without using genes that might trigger cancer.

This is how treatments based on a type of white blood cell called T - cells are curing some cancers, rather than just slowing their advance (see «Cancer meets its nemesis in reprogrammed blood cells «-RRB-.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

«How to reprogram cells in our immune system: The discovery could improve treatments for autoimmune diseases and cancer.»

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

In the future, such developments could enable cancer cells to be reprogrammed, thereby preventing them from dividing at an uncontrollable rate.

Summers and the research team, led by Dr. Mike Jensen at the Ben Towne Center for Childhood Cancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02 trial, approximately 40 percent of them relapsed with a leukemia that evolved to circumvent the CAR T cells that were reprogrammed to detect and destroy cCancer Research at Seattle Children's Research Institute, are opening PLAT - 04 after discovering that of the patients who relapsed in the PLAT - 02 trial, approximately 40 percent of them relapsed with a leukemia that evolved to circumvent the CAR T cells that were reprogrammed to detect and destroy cancercancer.

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

Researchers are also working to develop a trial where they will reprogram CAR T cells to identify the CD19 and CD22 proteins simultaneously, enabling them to target the cancer cells from more than one angle with the initial round of T - cell immunotherapy.

In this webinar we will explore how cancer cells are able to reprogram their metabolic pathways to enable energy production under conditions that are disabling to most normal cells.

«We now know much more about metabolic reprogramming of cancerous tissues in human patients, particularly that the activation of pyruvate carboxylase is important to lung cancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of Kencancer cell growth and survival,» said Fan, UK professor of toxicology and faculty member of the Markey Cancer Center and CESB at the University of KenCancer Center and CESB at the University of Kentucky.

«We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life - long increased susceptibility for diseases including cancer,» Prins says.

«We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life - long increased susceptibility to diseases including cancer,» Prins said.

New gene - editing technology that successfully reprogrammed cells to fight leukemia in a 14 - weeks - old infant could be applied to other cancers

Three teams of scientists reported earlier this year that they had directly reprogrammed adult mouse skin cells into embryonic cells, although the process involved viruses and cancer - causing genes.

By matching normal and cancer cells from a patient, we can now study the differences — what molecules are key to tumor development and growth, and, ultimately, match treatments that might disable this cancer,» says the study's senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the Center for Cell Reprogramming (CCR) at Georgetown University Medical Center.

One week after a breakthrough finding, scientists report they can reprogram human skin cells to behave like embryonic stem cells without a growth factor known to cause cancer

The sponge is implanted under the skin, and is designed to recruit and reprogram a patient's own immune cells «on site,» instructing them to travel through the body, home in on cancer cells, then kill them.

He adds that the stem cells used in the study have advantages over reprogrammed skin cells, including eliminating the tricky business of inducing the cells to become muscle cells, but he notes that both types of cells could pose risks because the virus used to modify them could cause cancer.

The Cancer Research UK team, based at the UCL Cancer Institute, has successfully fixed this fault in lung cancer cells — reprogramming the cells to self - desCancer Research UK team, based at the UCL Cancer Institute, has successfully fixed this fault in lung cancer cells — reprogramming the cells to self - desCancer Institute, has successfully fixed this fault in lung cancer cells — reprogramming the cells to self - descancer cells — reprogramming the cells to self - destruct.

• In March, a University of Wisconsin team reprogrammed skin fibroblasts into embryonic stem cells without incorporating the viral or other foreign DNA that can lead to complications like cancer.

In a relatively short period since its foundation in 2002, the CRG has generated important scientific insights in our understanding of the organization, deployment and evolution of genetic information, the internal workings of cells, their differentiation and reprogramming, their collective organization to form tissues and their alterations in disease, including cancer.

Using this approach, immune cells are taken from a patient's bloodstream, reprogrammed to recognize and attack a specific protein found in cancer cells, then reintroduced into the patient's system, where they get to work destroying targeted tumor cells.

Further, they present two new hallmarks — reprogramming of energy metabolism and evasion of immune destruction — that have emerged as critical capabilities of cancer cells.

With immunotherapy, we reprogram your immune cells, so they can do what they do best: Destroy infection and illness, like cancer.

Clarke notes that this kind of work — reprogramming normal cells to replace damaged tissues or organs in regenerative medicine, or even growing cells from an individual's cancer to determine what the best treatment is — speaks to the doctrine rather than challenges it.

No one yet knows what's actually going on in cells when they're reprogrammed, and cancer is still a very real problem, with most rodents that get iPS cells developing the disease.

Understanding these pathways, and the identification of the key proteins that control the ability of cancer cells to reprogram their metabolism through biochemical, and epigenetic or genetic alterations that make them resistant to therapies, is of paramount importance for the design of more targeted and therefore less toxic therapies.

While investigating one of the most commonly mutated genes in lung cancer, Shaw discovered an energy - sensing pathway that shuts down cell growth and reprograms metabolism when nutrients are scarce.

«Not only have we shown that we can reprogram skin cells, but we have also demonstrated that these reprogrammed cells can be differentiated into insulin - producing cells which hold great therapeutic potential for diabetes,» said study lead author Yi Zhang, Ph.D., Howard Hughes Medical Institute investigator, professor of biochemistry and biophysics at UNC and member of the Lineberger Comprehensive Cancer Center.

FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer types as well.

«It seems quite plausible from our results that reprogramming of enhancers enables cancer cells, generally, to achieve metastatic competence,» Vakoc says.

We will assemble leading experts to discuss basic immunology, cancer - immune cell interactions, and examine how tumor - associated inflammation can be reprogrammed for therapeutic benefit.

A team of researchers has engineered smart protein molecules that can reprogram white blood cells to ignore a self - defense signaling mechanism that cancer cells...

Bypassing apoptosis is a hallmark of cancer, and medical science is eager to find new ways of «reprogramming» cancer cells to die.

Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal

Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue - specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem - cell - based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource - based innovations.

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patients.

While the cancer normally excludes immune T - cells, the Evans lab discovered that modified vitamin D reprograms the cancer environment in a way that may allow the Merck drug Keytruda ® to invade and destroy the tumor.

An epigenetic factor reprograms gene enhancers, enabling cancer cells to «remember» an earlier developmental state and causing metastasis.

A brief history of stem cell research serves as an introduction, followed by coverage of stem cell fundamentals; chapters then explore embryonic and fetal amniotic stem cells, adult stem cells, nuclear reprogramming, and cancer stem cells.

«The epigenomic state of a cancer cell is totally different — it's been reprogrammed.»