Sentences with phrase «cancer driver genes»

«The loss or gain of multiple cancer driver genes that individually have low potency can add up to have big effects,» he said.

We have developed a sequencing based approach to show similar in human tissues, finding around a third of cells in normal sun exposed facial skin carry cancer driver gene mutations.

Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes.

«The major known cancer driver genes are often mutated in the primary tumor and all metastases, and successfully targeting them in therapy could provide widespread therapeutic benefit,» said Townsend.

The results, still in a preliminary stage, show that patients with a specific variant in the RET gene - a proto - oncogene or cancer driver gene; variant G2071A - could be more sensitive to this drug.

These findings provide new opportunities to develop drugs, which could switch Myc from a cancer driver gene to a deadly assassin of the cancer cells.