Sentences with phrase «cancer gene found»

Not exact matches

The company will now be able to sell health risk reports on three variants found on the BRCA1 and BRCA2 genes, which are linked with a higher risk of breast, ovarian, and prostate cancer.

At last year's Brainstorm Health conference in San Diego, Bergh found himself sitting at dinner with Othman Laraki, the cofounder and CEO of Color Genomics — a company that extracts the DNA from a customer's submitted saliva sample and then looks for a set number of gene mutations known to be associated with increased risk for developing certain hereditary cancers or heart conditions (depending on the test).

Editas, founded in 2013 in Cambridge, Massachusetts, is a visionary gene - therapy company with a pipeline of therapies for cancer and lung, liver, muscle, eye, and blood diseases.

Health matters: A recent study found that women with good nutrition are more likely to have babies born with a cancer - suppressing gene variant

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

The field of cancer epigenetics was recently transformed by the finding that genes encoding for epigenetic regulators are among the most commonly mutated genes in human cancers.

Teixeira and his team also found that a malfunctioning tumor - suppressing gene that's associated with certain cancers, such as colon and pancreatic, and is known as Stk11, additionally influenced the development of BPH.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

So Sandra Ryeom at the Children's Hospital in Boston and colleagues bred mice with three genes to find out if an extra copy gave them extra protection against cancer.

Bernard Friedenson, associate professor of biochemistry and molecular genetics at UIC, looked at the DNA sequences of breast cancers from 21 different women and found mutations in genes involved in immunity in every one of them.

«We found 74 genes with 123 aberrations involved in cancer growth.

If similar genes are found in people, drugs that mimic their protective effects could be a better strategy against cancer and ageing than simply mopping up all free radicals (PLoS Genetics, DOI: 10.1371 / journal.pgen.1000488).

«We were surprised to find cancer - linked genes in these benign endometriosis samples because these lesions do not typically become cancer,» says Papadopoulos, whose Ludwig Center laboratories performed the sequencing.

«Gene mutation findings may lead to treatment for liver cancer.»

«Machine learning finds tumor gene variants and sensitivity to drugs in The Cancer Genome Atlas.»

Since 1994, dozens more genes have been found that increase a woman's risk of hereditary breast cancer, but by how much is uncertain, confounding already complicated issues in genetic testing and counseling.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

The study also found that some of the morphing genes in the python's intestine, notably those in a signaling pathway called WNT, were genes that were involved in intestinal and other cancers.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

Bloch's colleagues at the National Institute of Environmental Health Sciences tested the oils in gene expression studies on lab - grown human breast cancer cells and found that they could mimic estrogens, the primary female sex hormones, and inhibit androgens, the primary male sex hormones.

Researchers at Moffitt Cancer Center hope to improve NSCLC patient survival with the results of a study that found that inherited genetic variations in interleukin genes are associated with improved patient survival and response to therapy.

«We found targetable FGFR gene fusions across a diverse array of cancer types.

In the study, they found that miR - 182 suppressed Bcl2L12, a cancer gene that blocks cancer cell death in response to chemo - and radiation therapy.

Moreno also found a homologue of a human cancer gene involved in cell competition.

Levels of a gene found in ovarian cancers could predict how well chemotherapy will work.

Earlier MD Anderson investigations demonstrated exosomes as a factor in detecting pancreatic cancer, but these latest findings reveal genetically altered exosomes as a potentially novel approach for direct and specific targeting of mutated KRAS, the cancer gene commonly linked to pancreatic cancer.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

«Genes may cause tumor aggressiveness, drug resistance in African - American prostate cancer: Research found many targeted therapies for prostate cancer may not be effective against tumors in African - American men.»

The first direct evidence has been found linking smoking to epigenetic changes in genes that help fight cancer.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

They say their study, published online in Endocrine Related Cancers, provides some surprising findings about HDAC inhibitors, which all seemingly do the same thing — remove the HDAC enzymes that wrap DNA so tightly that genes are silenced.

Now, researchers studying mice have found one of the most powerful tumor suppressor genes yet — animals lacking it have a startling 50 % chance of developing cancer.

Out of 750 genes measured, they found that every individual's cancer had a unique set of about 15 key genetic mutations.

Vogelstein, Kenneth Kinzler, and other colleagues found a minor change in the APC gene, which normally holds cell growth in check and can cause colon cancers when mutated.

The researchers found a set of frequently mutated genes in SBAs that could be helpful to clinicians when they are looking to use targeted therapies that work best in cancers with specifics mutations.

Since beginning a lab dedicated to understanding cancer metastasis at Rockefeller six years ago, Associate Professor Sohail Tavazoie has found that microRNAs — tiny strands of RNA that function as switches to inactivate specific genes — play an important role in controlling genes linked to metastasis.

Previous studies of genetic alterations in lymphoma and lung cancer have found that certain genetic mutations — specifically when part of a gene breaks off and gets fused to another — can inappropriately switch on ALK, driving cancer cells to grow and divide.

Scientists have identified unique genetic signatures strongly associated with a long and healthy life, findings that could help to further the understanding of how certain genes may offer protection from common age - related diseases like cancer, dementia and cardiovascular disease.

The findings provide proof of principle that restoring the function of a single tumor suppressor gene can cause tumor regression and suggest future avenues for developing effective cancer treatments.

PTEN prevents tumor cells from growing uncontrollably, and mutations in the gene encoding this protein are commonly found in many different types of cancer.

New research findings from Uppsala University and Uppsala Clinical Research Center show that smoking alters several genes that can be associated with health problems for smokers, such as increased risk for cancer and diabetes.

York University researchers have learned how living beings can keep gene expression in check — which might partly explain the uncontrolled gene expression found in many cancers.

«It is exciting to have found a way to selectively target gene delivery to cancer cells,» says Quiñones - Hinojosa.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

He found that genes that respond to hypoxia are known to also play a role in aging and in suppressing or promoting cancer.

For example, if scientists can find a way to turn down overexpression of these genes in cancer, we could disrupt cancer growth and prevent tumor progression.

Genes were found for familial breast cancer, for Huntington's disease, for fragile X syndrome.

They knew that they had found a new type of genetic defect, because the DNA in cancer cells from people with the altered gene was riddled with mutations.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

His troubles also led to an Institute of Medicine report that faulted Duke's oversight and found broad problems in the cancer field with using gene signatures and other biomarkers to guide treatment.