Sentences with phrase «cancer gene in mice»

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Insertional mutagenesis using engineered transposons is a potent forward genetic screening technique used to identify cancer genes in mouse model systems.

Not exact matches

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

So Sandra Ryeom at the Children's Hospital in Boston and colleagues bred mice with three genes to find out if an extra copy gave them extra protection against cancer.

They started with pairs of fat yellow mice known to scientists as agouti mice, so called because they carry a particular gene — the agouti gene — that in addition to making the rodents ravenous and yellow renders them prone to cancer and diabetes.

Northwestern Medicine scientists have identified a small RNA molecule called miR - 182 that can suppress cancer - causing genes in mice with glioblastoma mulitforme (GBM), a deadly and incurable type of brain tumor.

Moreno and his team already have shown that when cell - competition genes are knocked out in mice, cancer growth is inhibited.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

«In our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of MedicinIn our experiments, our nanoparticles successfully delivered a test gene to brain cancer cells in mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicinin mice, where it was then turned on,» says Jordan Green, Ph.D., an assistant professor of biomedical engineering and neurosurgery at the Johns Hopkins University School of Medicine.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

He examined the gene expression changes in mice well before some of them developed advanced cancers.

They then mutated three of these genes simultaneously in renal cells of mice, which then developed renal cancer.

Coussens and her U.C.S.F. colleagues Douglas Hanahan and Zena Werb reported in 1999 that mice engineered with activated cancer genes but without mast cells (another type of innate immune cell) developed premalignant tissue that did not progress to full malignancy.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

William Shawlot and Richard Behringer of the University of Texas M. D. Anderson Cancer Center in Houston created 125 headless mice by knocking out a gene called Lim1 in the developing embryos.

When the team turned the gene on in a set of colon cancer cells and injected them into mouse spleens, the cells spread into the animals» livers; cells that didn't make the L1CAM protein stayed put.

But researchers will have to figure out how to eliminate the viral DNA used to introduce the genes, which in Yamanaka's experiments led to cancers in 20 percent of mice grown from blastocysts.

In tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cellIn tests on human breast cancer cells and in special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cellin special immunodeficient mice with tissue grafts, the scientists found that both agents interfered with genes involved with breast cancer cell growth, resulting in more cancer cellin more cancer cells.

In the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in micIn the lab, the scientific team used an approach that combined functional RNAi analysis with gene expression analysis in breast cancer - derived cell lines and in human breast cancers replicated in micin breast cancer - derived cell lines and in human breast cancers replicated in micin human breast cancers replicated in micin mice.

The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

Foltz's team has also used the mouse atlas to help home in on two genes, known as BEX1 and BEX2, which seem to be silenced in a form of brain cancer called glioma.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA: gene interactions that influence bladder cancer.

This study, which will be published Oct. 24 in eLife, and two other new Northwestern studies in Oncotarget and Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

Yilmaz, who studies colon cancer and how it is influenced by genes, diet, and aging, decided to adapt this approach to generate colon tumors in mice.

A new study backs that idea, linking a gene that is triplicated in Down syndrome to a lower risk of colon cancer in mice.

Working with mouse prostate cancer cell lines in the laboratory, the investigators found that cells containing overexpressed TOP2A and EZH2 genes were highly sensitive to attack with a combination of two drugs.

A study in mice has found that variations in a gene that regulates the circadian clock seem to increase the chances of breast cancer spreading.

Looking at mice with differing risks of metastasis, Kent Hunter at the National Cancer Institute in Bethesda, Maryland, and his team found a circadian rhythm gene, Arntl2, seemed to be involved.

The team then validated this finding, by disrupting the KAT2A gene from leukemia cells in transgenic mice, and observing the effect on the cancer.

«A new tumor suppressor gene for breast cancer in mice.»

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

When the researchers extended the analysis to a separate group of patients and mice that had been exposed to tobacco smoke, they narrowed down the epigenetic modifications to several sites located in four genes that have been weakly linked to cancer before.

Additionally, the study showed that genetic knockdown of RASAL2 gene can lead to reduced metastasis in breast cancer mouse model.

This system could be used in combination with hundreds of existing mouse strains that have been engineered to express known cancer genes, allowing researchers to study more thoroughly the interactions of multiple genes.

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

Next steps include He's collaboration with Piedmont Atlanta Hospital to retrieve T cells, liver cancer cells and healthy tissue normally removed from patients during surgery, put the mouse receptor genes on these T cells and monitor in a dish both how those cells now fight the tumor and react to healthy human tissue.

Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.

The same effect was seen in a mouse model of human brain cancer containing this gene fusion.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

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Aug. 8, 2017 — Using bioinformatics approaches, Vanderbilt investigators have identified gene expression networks that are deregulated in mouse and human stomach cancers.

use CRISPR - Cas technology to carry out genome - wide screens of gene - gene, gene - drug and cancer - microenvironment interactions in cells and mice in order to explore fundamental biology and to identify drug targets and drug resistance / sensitisation mechanisms.

From the development of insulin and transplant surgery to modern day advances, including gene therapies and cancer treatments; animals — from mice to monkeys — continue to play a crucial role in both basic and applied research.

The research, published this month in PNAS, shows that the gene known as BRCA1 has a significant role in creating healthy brains in mice and may provide a hint as to why some women genetically prone to breast cancer experience brain seizures.

Now, they have investigated gene expression in low - grade dysplastic lesions and normal stomach tissue from mice and in gastric cancer and normal stomach tissue from humans.

Interestingly, the Salk researchers found that satellite de-repression was observed in both mouse and human BRCA1 - deficient breast cancers, and that restoration of BRCA1 repressed expression of the satellite genes by about 20-fold.

Largaespada's laboratory is working to exploit insertional mutagenesis for cancer gene discovery and functional genomics in the mouse.

Scientists exploit gene therapy to shrink tumors in mice with an aggressive form of breast cancer.

Researchers, funded by Cancer Research UK, from the Section of Gene Function and Regulation and the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate Cancer Research UK, from the Section of Gene Function and Regulation and the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate glGene Function and Regulation and the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate Cancer Research Centre at The Institute of Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate Cancer Research (ICR), have pinpointed early genetic changes that lead to cancer in mice lacking the BRCA2 gene in their prostate cancer in mice lacking the BRCA2 gene in their prostate glgene in their prostate gland.