Sentences with phrase «cancer gene profiling»

Not exact matches

He and his colleagues are now investigating how gene profiles are altered and whether these techniques could ease symptoms in people with high blood pressure, inflammatory bowel disease and multiple myeloma, a type of bone marrow cancer.

profile of NF B - regulated genes and to extract clinically relevant data that could potentially bear on optimal cancer prevention and treatment.

In a recent attempt, oncologist Todd Golub of the Dana - Farber Cancer Institute in Boston, Massachusetts, and his colleagues collected gene expression profiles, taken from public databases, from 76 tumors.

«Researchers have done metabolic studies in patients with adrenal cancer, but they have looked at larger molecules, and they have targeted their investigations at specific steroids or gene profiles.

Lead author Christina von Roemeling, a graduate student at Mayo Clinic in Florida, used genomic profiling of nearly 100 kidney cancer patient samples to identify genes that were either over-expressed or under - expressed as compared to patient matched normal kidney tissue samples.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

Lead author Johan den Boon, associate scientist with the Morgridge Institute for Research at the University of Wisconsin - Madison, says the research team used gene expression profiling on 128 specimens from the Study to Understand Cervical Cancer Early Endpoints and Determinants, or SUCCEED.

The three - year study included cell culture studies at Rice as well as a detailed analysis of gene - expression profiles of more than 500 patients from the Cancer Genome Atlas and protein - expression profiles from about 200 MD Anderson patients.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

The researchers identified the LSC17 score by sampling the leukemia stem cell properties of blood or bone marrow samples from 78 AML patients from the cancer centre combined with molecular profiling technology that measures gene expression.

She and her colleagues propose that other replication inhibitors to fight cancer will also produce unique double strand break profiles, as gene expression patterns would dictate the locations of replication - transcription conflicts.

«It has taken us years to assemble the clinical outcome database and tissue samples, generate the immunohistochemical biomarkers, gene expression profiles and analyse the data for this study — and we were delighted to find a definite link between alpha beta crystallin and breast cancer progression, which we hope will ultimately improve clinical outcomes.

Gene expression profiling tests, such as Oncotype Dx, analyze the patterns of 21 different genes within cancer cells to help predict how likely it is that a women's cancer will recur within 10 years after initial treatment and how beneficial chemotherapy will be to her.

Oncologists welcome gene expression profiling tests as an added tool in deciding whether women with early - stage breast cancer should have chemotherapy, a new study has found.

Altered promoters in GC change the gene expression profile of GC cells and may confer its oncogenic properties, including cell movement and cancer signalling.

Hormone ‐ replacement therapy influences gene expression profiles and is associated with breast ‐ cancer prognosis: a cohort study

In 2009 gene therapy rebounded from years of high - profile failures — including unexpected deaths and cancers — to produce startling triumphs.

High quality of DNA / RNA products is the foundation of successful cancer research such as analysis of genetic alterations, gene expression profiling and next generation sequencing.

Eric S. Lander and colleagues provide the first evidence that gene - expression profiling can distinguish between cancer types.

Using gene expression profile (GEP) tests like Oncotype DX to inform treatment decision - making for breast cancer is likely to be less cost - effective in community oncology practice than previous estimates had suggested, according to an economic simulation analysis published in the Journal of Clinical Oncology.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

Effects of warm ischemic time on gene expression profiling in colorectal cancer tissues and normal mucosa.

Chinnaiyan's lab, which has extensively analyzed how genes and proteins in prostate cancer cells reflect these changes, thought that profiling cells» metabolites would offer an even more «holistic picture of the molecular alterations that occur,» he said.

«Simultaneous mutation detection, copy number measurement, and digital gene expression profiling of high - grade serous ovarian cancer FFPE samples using Hyb & SeqTM targeted sequencing technology»

Dr. Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders (e.g. Miller and Kabuki syndrome) and autism; cell - free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays and saturation genome editing; whole organism lineage tracing; and massively parallel molecular profiling of single cells.

In addition, University of Michigan has developed one of the nation's largest and most sophisticated gene sequencing programs, allowing for customization of treatment plans based on each child's own genetic cancer profile.

In addition, profiling has been exploited to identify non-coding RNAs that may represent downstream targets of activated oncogenic pathways or that are targeting protein coding genes involved in cancer.

To determine the genetic profile of a patient's tumor and identify cancer - driving genes, our team of experts uses advanced genomic sequencing technology.

Mar. 12, 2015 — Louis Staudt, M.D., Ph.D., a pioneer in gene expression profiling at the National Cancer Institute (NCI), will deliver the next Flexner Discovery Lecture on Thursday, March 19.

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes.

We found that mutation accumulation in organoids deficient in the mismatch repair gene MLH1 is driven by replication errors and accurately models the mutation profiles observed in mismatch repair - deficient colorectal cancers.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

Tapscott applies the method to study regulation of gene expression in normal development of muscle tissue, while Olson uses it to identify genetic profiles of brain - cancer development.

366/12: 15 Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2: ERG fusion positive versus negative tumors.

Saturday, Oct. 21, 11:20 - 11:40 a.m., South Hall B, South Building Featured Plenary Abstract: Massively parallel reporter assays combined with cell - type specific expression quantitative trait loci profiling identified a functional melanoma risk variant in HIV - 1 inhibitor gene, MX2 J. Choi, National Cancer Institute, et al

She emphasized several times the value of TCGA's GBM sequencing as a reference cancer genome, with high - quality mutations already profiled for mutations, gene expression, etc..

Breast cancer; Hormone receptors, hormone responsiveness, gene expression profiling, mutant ER, metastasis, predictive markers

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.

Expression Profiling of Hereditary versus Sporadic Prostate Cancer Suggests CYR61, EGR3, KLF6 and SNF1LK as Differentially Expressed Genes