Sentences with phrase «cancer genome research»

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer Genome Research, 22 (2), 246 - 258 DOI: 10.1101 / gr.125872.111

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«Cancer cells disguise themselves by switching off genes, new research reveals: A genome - wide map of the genes switched off in aggressive tumors reveals a «signature».»

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

Horizon has partnered with The Wistar Institute of Anatomy and Biology in Philadelphia, Pennsylvania, to make available their large collection of highly characterized Melanoma PDX models to the research community; these models are representative of all previously well - described melanoma subtypes identified by The Cancer Genome Atlas.

He directs The Cancer Genome Atlas (TCGA), an initiative of the U.S. National Cancer Institute (NCI) and the U.S. National Human Genome Research Institute.

Silencing five genes whose expression negatively correlated with caspase activity significantly increased cancer cells» sensitivity to radiation (Genome Research, DOI: 10.1101 / gr.122044.111).

What's more, the highly connected «hub» miRNAs were often different for cancer cells (Genome Research, DOI: 10.1101 / gr.098046.109).

Readers will have at their fingertips key articles in the history of science from the late 19th through the early 21st centuries, including research about the human genome, breast and colon cancer genes, and the Bose - Einstein condensate in physics.

The findings are the latest from the St. Jude Children's Research Hospital — Washington University Pediatric Cancer Genome Project and appear in the December 9 edition of the scientific journal Cancer Cell.

The research team comprises representatives from National Cancer Centre Singapore (NCCS), Singapore General Hospital (SGH), Duke - NUS Graduate Medical School (Duke - NUS), A * STAR's Genome Institute of Singapore (GIS) and Cancer Science Institute Singapore (CSI Singapore) of the National University of Singapore (NUS).

The new research, which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant melanoma, suggests that telomerase plays a more complex role in cancer.

Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.

He has chaired numerous NIH committees and served on the National Advisory Council for Human Genome Research and the NCI Mouce Models for Human Cancer Consortium.

When The Cancer Genome Atlas Research Network reported its genomic profiling of clear - cell kidney tumours, about one - quarter of participants (126 patients) had been operated on at Memorial Sloan Kettering3.

New research led by Li Ding, Ph.D., of Washington University School of Medicine in St. Louis, shows that current approaches to genome analysis systematically miss detecting a certain type of complex mutation in cancer patients» tumors.

Researchers using data collected by the Ovarian Cancer Association Consortium have discovered uncommon variants in new regions of the genome that influence ovarian cancer risk, and will present their findings on April 6, 2014 at the American Association for Cancer Research Annual Meeting in San DiegCancer Association Consortium have discovered uncommon variants in new regions of the genome that influence ovarian cancer risk, and will present their findings on April 6, 2014 at the American Association for Cancer Research Annual Meeting in San Diegcancer risk, and will present their findings on April 6, 2014 at the American Association for Cancer Research Annual Meeting in San DiegCancer Research Annual Meeting in San Diego, CA.

Using Epiviz and Bioconductor, the research team found consistent regions of DNA methylation changes in colon cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer cancer types.

The St. Laurent Institute, a non-profit medical research institute focused on the systems biology of disease, today announced in a study published in the July edition of Genome Biology, that genetic matter, previously ignored by the scientific community, may play an important role in cancer.

The research groups then examined the landscape of the pancreatic cancer epigenome using a combination of stains on patient tissues, direct examination of the proteins that wrap DNA and whole - genome sequencing of the detected epigenetic changes to map precisely where they were located.

The research team from the National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifyinresearch team from the National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifyinResearch Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying fungi.

The molecular mechanisms involved in the development of cancer have been uncovered by extensive research over the past 30 years, culminating in The Cancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel ccancer have been uncovered by extensive research over the past 30 years, culminating in The Cancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel cCancer Genome Atlas, a National Institutes of Health project that identified and characterized many genetic mutations that fuel cancercancer.

This work was carried out with funding from the Association for International Cancer Research (United Kingdom), the Lymphoma Research Foundation (USA) and the Instituto de Salud Carlos III (Spain), and illustrates how new genome sequencing technologies are revolutionizing the study of different types of cCancer Research (United Kingdom), the Lymphoma Research Foundation (USA) and the Instituto de Salud Carlos III (Spain), and illustrates how new genome sequencing technologies are revolutionizing the study of different types of cancercancer.

But Stratton is convinced that in a few years time, once the full pattern of the cancer genome is revealed, his next group of students will ask the same question about the present state of research.

Nevertheless, trying to develop new therapies based on what treatments will look like in the coming decade is a nearly impossible task, points out Michael Stratton, joint head of the Cancer Genome Project and professor of cancer genetics at the University of London's Institute of Cancer Research, who has been working on developing finely targeted cancer treatments since identifying the BRAF oncogene inCancer Genome Project and professor of cancer genetics at the University of London's Institute of Cancer Research, who has been working on developing finely targeted cancer treatments since identifying the BRAF oncogene incancer genetics at the University of London's Institute of Cancer Research, who has been working on developing finely targeted cancer treatments since identifying the BRAF oncogene inCancer Research, who has been working on developing finely targeted cancer treatments since identifying the BRAF oncogene incancer treatments since identifying the BRAF oncogene in 2002.

To answer that question, they analyzed genome sequencing data from The Cancer Genome Atlas and epidemiologic data from the Cancer Research UK database, developing a mathematical model that allowed them to determine the proportion of cancer mutations that resulted from R, hereditary or environmental mutations, respectgenome sequencing data from The Cancer Genome Atlas and epidemiologic data from the Cancer Research UK database, developing a mathematical model that allowed them to determine the proportion of cancer mutations that resulted from R, hereditary or environmental mutations, respectCancer Genome Atlas and epidemiologic data from the Cancer Research UK database, developing a mathematical model that allowed them to determine the proportion of cancer mutations that resulted from R, hereditary or environmental mutations, respectGenome Atlas and epidemiologic data from the Cancer Research UK database, developing a mathematical model that allowed them to determine the proportion of cancer mutations that resulted from R, hereditary or environmental mutations, respectCancer Research UK database, developing a mathematical model that allowed them to determine the proportion of cancer mutations that resulted from R, hereditary or environmental mutations, respectcancer mutations that resulted from R, hereditary or environmental mutations, respectively.

Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified novel genomic and molecular characteristics of cervical cancer that will aid in the subclassification of the disease and may help target therapies that are most appropriate for each paCancer Genome Atlas (TCGA) Research Network have identified novel genomic and molecular characteristics of cervical cancer that will aid in the subclassification of the disease and may help target therapies that are most appropriate for each pacancer that will aid in the subclassification of the disease and may help target therapies that are most appropriate for each patient.

The researchers, including scientists from The Genome Institute at Washington University School of Medicine, presented the research titled, «Patient - derived xenograft study reveals endocrine therapy resistance of ER + breast cancer caused by distinct ESR1 gene aberrations.»

This was the challenge addressed by Mary - Claire King, Ph.D., American Cancer Society Professor of Medicine and Genome Sciences, and Tomas Walsh, Ph.D., Associate Research Professor of Medical Genetics, both at the University of Washington, Seattle.

Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily.

Already researchers at the Cancer Genome Atlas project (a collaboration of the National Cancer Institute and the National Human Genome Research Institute) are sequencing mutations involved in more than 20 types of cCancer Genome Atlas project (a collaboration of the National Cancer Institute and the National Human Genome Research Institute) are sequencing mutations involved in more than 20 types of cCancer Institute and the National Human Genome Research Institute) are sequencing mutations involved in more than 20 types of cancercancer.

It's an «elegant study» and «a well - documented example of this fascinating interplay between ERVs and their host organism,» says Dixie Mager, a geneticist at British Columbia Cancer Agency in Vancouver, Canada, who researches how genetic elements sometimes «jump» around genomes.

A simple blood test is currently in development that could help predict the likelihood of a woman developing breast cancer, even in the absence of a high - risk BRCA1 gene mutation, according to research published in the open access journal Genome Medicine.

Co-senior author on the Cancer Cell study, Dr. Matthew Wilkerson, associate professor and Bioinformatics Director of The American Genome Center and the Collaborative Health Initiative Research Program at the Uniformed Services University.

Researchers at the Children's Medical Center Research Institute (CRI) at UT Southwestern have discovered that cells in the liver with whole genome duplications, known as polyploid cells, can protect the liver against cancer.

The research is part of the International Cancer Genome Consortium (ICGC)-- a global project using the latest gene - sequencing technology to reveal the genetic changes driving the disease.

To help detect genetic mutations and better understand this disease, a group of researchers at USU and the nationwide Cancer Genome Atlas Research Network examined 173 tumors, performing six genomic tests, such as DNA and RNA sequencing.

In 2012, the St. Jude Children's Research Hospital — Washington University Pediatric Cancer Genome Project highlighted DDX3X as a promising focus for efforts to develop targeted therapies against medulloblastoma.

Following a postdoctoral fellowship in the National Human Genome Research Institute at the National Institutes of Health (NIH), Dr. Wei stayed on at NIH, first as a biologist and currently as a staff scientist, in the Pediatric Oncology Branch of the National Cancer Institute.

«We're not saying there's no point» to whole - genome sequencing, says Vogelstein, who presented the findings here today at the annual meeting of the American Association for Cancer Research.

Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open access journal Genome Biology.

Dr. Mardis has research interests in the application of DNA sequencing to characterize cancer genomes and transcriptomes, and using these data to support therapeutic decision - making.

She serves as an editorial board member of Molecular Cancer Research, Genome Research, and Molecular Oncology in addition to serving on the scientific advisory boards of Pacific Biosciences, DNA Nexus, and Edge Biosciences.

«All of these [studies] are pretty important for cancer research,» says cancer geneticist Paul Meltzer of the National Human Genome Research Institute in Bethesda, Mresearch,» says cancer geneticist Paul Meltzer of the National Human Genome Research Institute in Bethesda, MResearch Institute in Bethesda, Maryland.

Following his postdoctoral training at the INSERM U. 311 in Strasbourg, France and the Cancer Genetics Branch at the National Human Genome Research Institute in Bethesda, Maryland, Dr. Azorsa joined the Translational Genomics Research Institute (TGen) based in Phoenix, Arizona.

The study analyzed data from The Cancer Genome Atlas (TCGA), a research program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cCancer Genome Atlas (TCGA), a research program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types ofresearch program supported by the National Cancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cCancer Institute and National Human Genome Research Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types ofResearch Institute within the National Institutes of Health that is looking at genomic changes in more than 20 different types of cancercancer.

This information is crucial to understand how cells maintain their identity and protect their genome, which is essential to avoid cancer development,» says associate professor Anja Groth, who has been heading the research team.

The researchers from the University of South Carolina College of Pharmacy and School of Medicine discovered this new subtype by analyzing data from 255 cervical cancer samples in The Cancer Genome Atlas, a large - scale federally funded project launched in 2005 by the National Cancer Institute and National Human Genome Research Instcancer samples in The Cancer Genome Atlas, a large - scale federally funded project launched in 2005 by the National Cancer Institute and National Human Genome Research InstCancer Genome Atlas, a large - scale federally funded project launched in 2005 by the National Cancer Institute and National Human Genome Research InstCancer Institute and National Human Genome Research Institute.

Interpretation of genome sequencing data is a significant challenge because of the volume of genomic data to sift through, as well as the large, growing body of research on molecular drivers of cancer and potential targeted therapies.

This work is as part of the International Cancer Genome Consortium (ICGC) Research Projects.

Filed Under: Cancer Genomics, Uncategorized Tagged With: cancer, DNA, genetics, genome, genomics, illumina, research, sequCancer Genomics, Uncategorized Tagged With: cancer, DNA, genetics, genome, genomics, illumina, research, sequcancer, DNA, genetics, genome, genomics, illumina, research, sequencing