Sentences with phrase «cancer immune escape»

«This is the first study to illustrate that a structural abnormality in the 3» untranslated region of the PD - L1 gene causes an abnormally high production of PD - L1 protein, consequently aiding cancer immune escape,» says one of the lead authors, Keisuke Kataoka, at Kyoto University.

Not exact matches

But cancer cells can escape immune surveillance using a variety of techniques to disguise themselves.

This may explain how cancer cells escape detection by our body's immune system.

In addition to formulating diagnostic strategies for cancer immunotherapy agents, her team is focused on developing a deep understanding of tumor immune biology as well as mechanisms associated with immune response and immune escape in cancer patients, with the intent of generating rational strategies for the creation of combination therapies.

Therefore, having less MHC I molecules may allow cancer cells to hide better and escape detection by the immune system.

Cancer cells can leverage such mechanisms to escape the immune system response.

Publishing in Nature, the study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Then, they treated the dormant cells with a product of the immune system, they found that dormant cells were susceptible to immunotherapy, and that quiescent, but not indolent cancer cells, could not escape from immunotherapy.

Publishing in Nature, a recent study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Conversely, the immune system contains triggers to blunt immune responses, and antibodies that block these «off - switch» checkpoints might be able to further reduce the ability of these cancers to escape the immune system.

A team of scientists from Singapore has discovered new ways in which cancers can escape the body's immune system.

More recently, we have learned that it is critical to understand the biology of cancer plasticity to identify the mechanisms that allow tumours to resist or escape immune control.

Some of our next steps are to determine the biological process that causes cancer cells to express non-mutated, shared antigens, and the means by which dormant metastases escape immune elimination.

In fact, some researchers are even suggesting that lung cancers use the PD - 1 pathway to escape immune destruction in the first place.

What this suggests is that lung cancers are able to take hold in the lungs by disarming T cells and escaping the immune system's control.

CRI postdoctoral fellow Dr. Haihui Lu at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, is studying some of the unique characteristics that differentiate metastatic cancer cells from primary tumor cells, and specifically aims to understand how these unique characteristics enable breast cancer cells to escape elimination by the immune system.

This past October, led by postdoc Nicholas McGranahan and graduate student Rachel Rosenthal, Swanton's lab found one way that lung cancers evolve to escape detection by the immune system.

Here, we review the current state of the art of somatic cancer evolution and mechanisms of immune control and escape.

Cancer cells have developed a number of ways to survive, including ways to escape detection and attack by our immune system, but their ability to respond to viral infections is actually quite limited.

Based on this data, researchers concluded that learned helplessness in rats who couldn't escape the shocks must have suppressed the immune response known to fight off cancer cells in tumors of this sort.