Sentences with phrase «cancer immunosurveillance»
Type - I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance.
https://science.institut-curie.org/ Not exact matches
But University of California San Diego School of Medicine researchers have now found that chronic liver inflammation also promotes cancer by suppressing immunosurveillance — a natural defense mechanism in which it's thought the immune system suppresses cancer development.
«Recent successes in cancer immunotherapy — in the form of immune checkpoint inhibitors and adoptive T cell transfer — demonstrate how activated immune cells can eradicate tumors, but until now we didn't fully appreciate immunosurveillance or the role of adaptive immunity in tumor formation,» said senior author Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.
This study adds to the discussion about the role of this immunosurveillance in the risk of developing the common cancers among those with compromised immune systems,» adds first author Paul Mayor, MD, Fellow in the Department of Gynecologic Oncology at RPCI.
The results of her project will help scientists develop novel therapies to target the regulatory proteins that cause CD47 overproduction in leukemia and other cancer stem cells, with the goal of restoring immunosurveillance and enabling the immune system to recognize and destroy these aberrant cancer cells.