Sentences with phrase «cancer in laboratory mice»

The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

(It's relatively easy to cure cancer in laboratory mice — «If you can't cure cancer in a mouse,» a cancer researcher once said to me, «then you should change careers» — but certainly not easy in people.

Not exact matches

Laboratory mice that have received rapamycin have reduced the age - dependent decline in spontaneous activity, demonstrated more fitness, improved cognition and cardiovascular health, had less cancer and lived substantially longer than mice fed a normal diet.

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

«Despite the low infection levels of mouse cells with oHSV, we were able to cause a delay in tumor growth in one of the cancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood Discancer models and even cure many of the mice in a second model,» said first author Jennifer Leddon, who conducted much of the laboratory work during a research experience in the Center for Childhood Cancer and Blood DisCancer and Blood Diseases.

Apart from a few studies in mouse models and in cell lines, there is no laboratory evidence that synthetic phosphoethanolamine works as a cancer drug.

In his current position at The Jackson Laboratory, he has overall responsibility for the ongoing operational development of the PDX resource, which generates, banks, and distributes patient - derived xenograft (PDX) mouse models of human cancers.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cells.

In both laboratory dishes and mice with human prostate cancers, the nanoparticles proved extremely effective.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micIn their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micin women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratorycancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratorycancer patients treated at the Cancer Institute into laboratoryCancer Institute into laboratory mice.

Researchers in the Cedars - Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents.

Working with mouse prostate cancer cell lines in the laboratory, the investigators found that cells containing overexpressed TOP2A and EZH2 genes were highly sensitive to attack with a combination of two drugs.

He said experiments are under way to test the two - drug combination in laboratory models of metastasis - prone prostate cancer, leading eventually to tests in mouse models.

But while most PDX mice are used as general models of human cancer in the laboratory, others seek to use them as Fiebig originally hoped — as avatars to guide customized patient care.

Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.

These days, mice grafted with human tumors, known as patient - derived xenograft (PDX) mice, are common in cancer research laboratories.

In 2012 she joined the laboratory of Dr. D.L. Konotyiannis at BSRC AL.Fleming, Greece as postdoctoral scientist, where she worked on the study of the RNA Binding Protein HuR during intestinal and lung inflammation and cancer, using inducible, KO and Tg mouse models and xenografts.

Largaespada's laboratory is working to exploit insertional mutagenesis for cancer gene discovery and functional genomics in the mouse.

«Mouse models of human cancer have taught us a great deal about the basic principles of cancer biology,» says Inder Verma, Ph.D., a professor in the Laboratory of Genetics.

In the laboratory of Dr. Mintz, an eminent developmental geneticist, Dr. Jaenisch learned the embryological techniques that would lead to the development of the first transgenic mice carrying foreign sequences in all tissues — an approach that has proved to be critically important to understanding cancer, neurological and connective tissue diseases, and developmental abnormalitieIn the laboratory of Dr. Mintz, an eminent developmental geneticist, Dr. Jaenisch learned the embryological techniques that would lead to the development of the first transgenic mice carrying foreign sequences in all tissues — an approach that has proved to be critically important to understanding cancer, neurological and connective tissue diseases, and developmental abnormalitiein all tissues — an approach that has proved to be critically important to understanding cancer, neurological and connective tissue diseases, and developmental abnormalities.

RNA from prostate cancer tissues corresponding to the 39 individuals identified in the prospective study was initially extracted in a separate mouse - free, XMRV PCR amplicon - free laboratory (University of California, San Francisco).

With rudimentary laboratories, one could argue that more was accomplished with regards to the effect of diet on cancer in the former half of the century, as revolutionary researchers like Tannenbaum, Rous, and their colleagues provided us with dozens of animal studies linking diet and cancer by exposing mice to free radical - laden vegetable oils.32, 33 Several decades later, two other researchers, Dayton and Pearce, provided one of the few studies revealing what happens when we give humans vegetable oils and their accompanying free radicals when they randomized men to a corn oil solution and a similar rise in cancer followed.34 It is no surprise that corn oil is often used in animal studies to cause cancer, as the ingestion of damaging free radicals predictably hastens cancer development.35 Furthermore, these scientists were the first to show that fasting, restricting calories, and cutting carbohydrates could lower the chance of cancer in animals exposed to dangerous chemicals and carcinogens.

Among it's valuable components are gamma - linolenic acid (GLA), linoleic and arachidonic acids, vitamin B12 (needed, especially for vegetarians, for healthy red blood cells), iron, a high level of protein (60 to 70 percent), essential amino acids, the nucleic acids RNA and DNA, chlorophyll, and phycocyanin, a blue pigment that is found only in blue - green algae and that has increased the survival rate of mice with liver cancer in laboratory experiments.