Sentences with phrase «cancer initiation»
"Cancer initiation" refers to the process through which normal cells in the body begin to transform into cancer cells and develop into a tumor or malignant growth. It involves genetic changes or mutations that cause cells to divide and grow uncontrollably, potentially leading to the development of cancer. Full definition
Estrogens as Endogenous Genotoxic Agents: DNA Adducts and Mutations Remarks: Dr. Joachim Liehr, Stehlin Foundation for Cancer Research Dr. Ercole Cavalieri, University of Nebraska Medical Center Catechol Estrogen -3,4-Quinones and Apurinic Sites in Cancer Initiation Dr. Ercole Cavalieri, University of Nebraska Medical Center Endogenous Oxidants and DNA Damage Dr. Krystyna Frenkel, New York University Medical Center
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But if, as this study suggests, the way that cells become proliferative again is similar across many different organs, we can imagine therapies that interfere with cancer initiation in a more global way, regardless of where that cancer may appear in the body,» he explains.
His current research focuses on the molecular mechanisms underlying lung cancer initiation, progression, and metastasis.
The mission of our lab is to improve therapy for patients with brain tumors by elucidating the molecular mechanisms driving cancer initiation and progression, and in doing so, promote rigorous science and train the next generation of scientists.
Jean - Christophe Larsimont and colleagues used state of the art genetic mouse models to dissect the functional role and molecular mechanisms by which Sox9 controls skin cancer initiation and invasion.
YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up - regulation of JAK - STAT3 Signaling.
We want to understand more about how these monocyte subsets impact cancer initiation and progression.
We have four major research programs on: (a) understanding the polarization machinery of mammalian epithelial cells (b) control of epithelial homeostasis in mammary gland morphogenesis, breast cancer initiation and metastasis (c) the role of stem cells and mechanisms controling stemness in the mammary gland and in breast cancer (d) the role of a novel exonuclease in DNA repair of inter-strand crosslinks.
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
It has also been assumed that 5α - DHT is a key contributor to prostate cancer initiation and progression, so 5AR inhibitors are commonly used to treat prostate cancer.
Animals starting with the most cancer initiation (high - aflatoxin dose) developed substantially less foci when fed the 5 % protein diet.
Rats fed with adequate amounts of proteins protect themselves better from cancer initiation compared to malnourished rats, but high proteins diets also stimulates cancer growth.
They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.
Furthermore, by combining this information with the characterization of mice genetically engineered to develop lung tumours, we attempt to elucidate the key genes driving lung cancer initiation, progression and response to therapy.
PDAC genetic analyses show that KRAS mutations are encountered in a majority of patients and play a significant role in cancer initiation, progression and metastasis.
One of his professors, Dag Jenssen, persuaded Helleday to join his lab in the Department of Genetics, Microbiology, and Toxicology at Stockholm University to investigate the importance of recombination in somatic cells, tumor cells, and cancer initiation.
MET is overexpressed in up to 60 % of ovarian tumors and its activation has been implicated in both cancer initiation and in advanced cancers with poor prognosis.
Therefore, we have explored the role of the alpha2 beta1 integrin in cancer initiation and progression using a clinically - relevant, spontaneous mouse model, the MMTV - Neu model of breast cancer progression and metastasis.
The authors hope that this study into origin licensing in PSCs and the discovery of a link between cell differentiation and DNA replication will further direct investigations into the early stages of developmental biology, cancer initiation and progression, and regenerative medicine.
However, because mature cells in the stomach, pancreas, liver, and kidney all activate the same genes and go through the same process when they begin to divide again, the findings could mean that cancer initiation is much more similar across organs than scientists have thought.
Discerning how transcriptionally formed R - loops contribute to cancer initiation and progression