Sentences with phrase «cancer lung metastasis»

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

In the orthotopic breast cancer model around 12 % of tail injected iPSC - EPCs homed to the mammary pad region, while in the breast cancer lung metastasis model iPSC - EPCs were distributed predominantly to the lung region.

Not exact matches

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

E2F1 is known to contribute to the development of cancer by promoting cancer cell proliferation; however, this is the first time that E2F1 has been shown to contribute to metastasis of lung cancer.

«Protein pathway involved in nicotine - induced lung cancer metastasis found.»

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

In the first series of tests, researchers found that luteolin inhibited the metastasis of triple - negative cancer in the lungs of affected mice.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

Breast cancer has a high rate of metastasis to bone, lung, liver, lymph nodes, and the brain.

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

By identifying the cause of this metastasis — which often happens quickly in lung cancer and results in a bleak survival rate — Salk scientists are able to explain why some tumors are more prone to spreading than others.

«New gene discovered that stops spread of deadly cancer: Scientists identify gene that fights metastasis of a common lung cancer.»

Their initial experiments found increased bone activity in two mouse models of a common form of lung cancer and in 70 lung cancer patients, even in absence of bone metastasis.

When cancer cells from eg breast or lung tumours invade the bones through metastasis, the bone tissue is degraded.

«BMI1 plays a substantial role in many solid tumors, including one of the most aggressive models of lung cancer, and its expression is linked with tumor growth, invasion, metastasis, prognosis and recurrence,» Levantini said.

«In this study, we found that enhanced neuropilin - 1 (NRP - 1) and NEDD9 levels in endometrial and lung cancer positively correlated with metastasis, while liver kinase B1 (LKB1) inhibited the migration of cancer cells.»

The high amounts of dietary sugar in the typical Western diet may increase the risk of breast cancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer Ccancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer CCancer Center.

Cancer biologist Joan Massagué of the Memorial Sloan - Kettering Cancer Center in New York City uncovered the new clues by studying breast cancer metastasis, in which malignant cells tend to spread to the bones and Cancer biologist Joan Massagué of the Memorial Sloan - Kettering Cancer Center in New York City uncovered the new clues by studying breast cancer metastasis, in which malignant cells tend to spread to the bones and Cancer Center in New York City uncovered the new clues by studying breast cancer metastasis, in which malignant cells tend to spread to the bones and cancer metastasis, in which malignant cells tend to spread to the bones and lungs.

Shah and his team are currently developing similar animal models of brain metastasis from lung cancers and from melanoma.

Of the colon cancer patients that develop metastases, 40 % present metastasis first to the liver and later to the lung, always in this clinical order of appearance.

She studies the process of cancer initiation and progression along with cancer stem cells, the evolution of drug resistance and the dynamics of metastasis formation focusing on lung, brain, breast and pancreatic cancers.

AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): preclinical evidence and clinical cases.

Toyokawa G, Seto T, Takenoyama M, Ichinose Y. Insights into brain metastasis in patients with ALK + lung cancer: is the brain truly a sanctuary?

What: The Second Edition of the IASLC Staging Manual in Thoracic Oncology reports on the latest revisions of the tumor, node and metastasis (TNM) classifications of thoracic malignancies, namely, lung cancer, malignant pleural mesothelioma, carcinoma of the esophagus and of the esophago - gastric junction and thymic epithelial tumors.

Long - term survival in patients with non-small cell lung cancer and synchronous brain metastasis treated with whole - brain radiotherapy and thoracic chemoradiation.

[39] These results underscore the importance of monitoring long - term treatment of CNS metastasis in this subtype of lung cancer, and the importance of focusing on non — WBRT - based treatments to achieve a meaningful response.

Extended survival and prognostic factors for patients with ALK - rearranged non-small-cell lung cancer and brain metastasis.

A peptide that inhibits function of Myristoylated Alanine - Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis

Depletion of ABL kinases does not inhibit metastasis of 4175 breast cancer cells, which show tropism to the lung.

His current research focuses on the molecular mechanisms underlying lung cancer initiation, progression, and metastasis.

Whitehead Institute researchers have found that an ancient, highly conserved cell survival factor drives expression of a specific set of genes that is strongly associated with metastasis and death in patients with breast, colon, and lung cancers.

Cancer that comes from another part of the body to the lungs is called pulmonary metastasis.

The 1833 (bone metastasis), 4175 (lung metastasis), and BrM2a (brain metastasis) sublines were derived from the parental cell line MDA - MB - 231 (19) and were gifts from J. Massague (Memorial Sloan - Kettering Cancer Center).

Studies on the effects of GHRH antagonists on prostate and lung cancers demonstrated their ability to modulate signaling pathways involved in cellular proliferation, survival, metastasis, and apoptosis.

The experimental metastasis assay we detail here includes tail - vein injection of cancer cells into the mouse and determination of the resulting secondary organ colonization, primarily in the lung, 10 d post dosing.

Lung cancer metastasis could be stopped by targeting a couple of proteins in the Golgi apparatus, reported a study.

Finally, to determine whether LARP7 KD also results in an increase in breast cancer metastasis in vivo, the T47D control or shLARP7 - 2 cells were injected intravenously into the nude mice, and lung metastasis was examined 12 weeks later.

Now, a study published by the University of Texas MD Anderson Cancer Center is confirming that too much sugar can lead to breast cancer and metastasis to the Cancer Center is confirming that too much sugar can lead to breast cancer and metastasis to the cancer and metastasis to the lungs.

The limitations of the chemo beads Although cisplatin beads are often effective at preventing or slowing the cancer from coming back, they do not prevent spreading (metastasis), e.g. to the lungs.

Hi Pearl, my cat was diagnosed with spleen cancer with metastasis in the lungs based only on ultrasound.

The cancer also spread to the lungs (metastasis), but it has been held in check by the vaccine.

Death mostly occurs in treated dogs due to metastasis (cancer spreading) & recurrence of lung cancer.

Spread of cancer (metastasis) from the mammary glands, liver, lung or prostate to the bones is relatively common.

Chemodectomas have historically been thought of as being relatively benign (i.e., not very aggressive cancers that typically grow slowly and do not spread), but some of these cancers will spread to other parts of the body (e.g., lungs and lymph nodes) through a process called metastasis.

Risk factors for bone metastasis in patients with primary lung cancer: study protocol for a systematic review