Sentences with phrase «cancer microenvironment»
Zou's group was the first to show PD - L1 expression, regulation and functional blockade in dendritic cells in the human cancer microenvironment.
https://www.uofmhealth.org/
We have shown that invariant Natural Killer T cells (iNKT), a subset of CD1d - restricted T cells displaying innate effector functions, rewire the prostate cancer microenvironment leading to cancer control.
Cancer cells are shown in green, Musashi expression in red and blue includes cells within the cancer microenvironment.
Not exact matches
«These occult lung cancer cells have found a unique way to co-opt the «brain microenvironment» and survive,» said Nguyen.
Metastatic melanoma is the deadliest of the skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain microenvironment remain shrouded in mystery.
The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.
Yet in a study led by Aimy Sebastian, a graduate student in the School of Natural Sciences at UC Merced who is conducting her Ph.D thesis work under Loots, identified the secreted bone protein Sclerostin (SOST), as a key molecule dysregulated as a result of prostate cancer - bone microenvironment interactions.
Development of new therapies for the prevention and treatment of prostate cancer bone metastasis depends on understanding the dynamic reciprocal interactions between prostate cancer cells and the bone microenvironment.
This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.
«Ionizing radiation found to soften tumor cell microenvironment: When irradiated, less stiff extracellular matrices reduced cancer growth and migration, bolstering the case to further understand fractionated radiation therapy.»
«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.
«These findings suggest that BLBC cells have an innate ability to establish a local microenvironment that is supportive of cancer stem cells,» explained Thiagalingam, associate professor in Genetics & Genomics, Medicine, and Pathology & Laboratory Medicine, at BUSM.
Co-senior study investigator and cancer biologist Iannis Aifantis, PhD, says the study offers the first evidence that «drugs targeting and disrupting leukemia cells» microenvironment — or what goes on around them — could prove effective against the disease.»
In fact, associations of cancer cells with the normal peritumoral microenvironment can profoundly impact tumor growth and development.
The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cCancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cancercancer.
Here, they observed that while estrogen receptor was absent in cancer cells, it was prevalent and in many cases increased in the so - called tumor microenvironment — the area around the tumor that helps it grow.
Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature — the small blood vessels that transport blood within tissues — as a niche where dormant cancer cells reside.
Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival.
The result is an immune system less able to fight the virus, and, if the virus causes cancer, a «microenvironment» near the tumor in which the immune system is suppressed.
Instead, tumors should be considered as complex tissues in which the cancer cells communicate directly and indirectly with the surrounding cellular microenvironment and evolve traits that promote their own survival.
«Understanding the crosstalk between acinar cells with Kras mutations and the microenvironment of those cells is key to developing targeted strategies to prevent and treat this cancer,» he says.
If there is a microenvironment that provides the context for activating cells that can spread cancer, then that's important to know.»
Managing the microenvironment is an emerging approach to treat many diseases, from cancer to cardiovascular disease to neurodegeneration.
«Our findings suggest that evaluating the composition of this microenvironment, in addition to mammographic density, could potentially provide a better assessment of breast cancer risk,» Chaudhuri says.
«The key to taking cancer vaccines to another level is combining them with immunotherapies that target the tumor microenvironment,» Kwak said.
Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.
GLUD1 and SLC25A13 may serve as new targets in treating refractory colorectal cancer, which survives in malnutritional microenvironments.»
Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel thCancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel thcancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.
In cancer, the protein helps malignant tumors evade the immune system as they metastasize and alter their microenvironment in a stealth type of expansion.
It suggests a new pathway to target in the microenvironment for cancer cells.»
«Our research shows that the protein GSK3 plays a crucial role in helping B cells meet the energy needs of their distinct states,» says Robert Rickert, Ph.D., director of the Tumor Microenvironment and Cancer Immunology Program at Sanford Burnham Prebys Medical Discovery Institute (SBP).
Numerous studies have already shown that cancer spreads particularly aggressively if there is an unfavorable balance between suppressing and active immune cells in the tumor microenvironment.
Cells of the latter cancer types contain many DNA mutations, which are thought to make distinctive «neoantigens» that help the patient's immune system recognize and attack tumors, and make the cancer cells» «microenvironment» hospitable to tumor - fighting T cells.
In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of the osteoblastic or osteolytic phenotype.
We decided to look at the exosomes of stromal cells, a type of cell that is commonly found in the tumor microenvironment, and see if stromal exosomes were influencing the energy consumption of cancer cells.»
According to the study's results, the microenvironment of a tumor cell has significant impact on cancer metastasis.
«Our original hypothesis was that cancer cells were modifying their metabolism based on communications they were receiving from cells in the microenvironment near the tumor,» said Nagrath, assistant professor of chemical and biomolecular engineering at Rice and co-author of a new study describing the research in the open - access journal eLife.
«Pancreatic cancer is a deadly disease and is very understudied when it comes to how it communicates with the microenvironment,» says senior author Ronald Evans, director of Salk's Gene Expression Laboratory, a Howard Hughes Medical Institute investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology.
This discovery by Siyuan Zhang at the University of Notre Dame and a team at the University of Texas MD Anderson Cancer Center has focused attention on fighting cancer in the tumor cell's microenviroCancer Center has focused attention on fighting cancer in the tumor cell's microenvirocancer in the tumor cell's microenvironment.
Next, Mao and colleagues developed a way to study how genes and the tumor microenvironment influence cancer development.
They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.
«A growing body of evidence suggests that exosomes can facilitate crosstalk between cancer cells and other types of cells that are nearby in the microenvironment that surrounds the tumor,» said Hongyun Zhao, the first author of the eLife study.
We found that cancer susceptibility is related to the complex interplay between exposure to low - dose radiation, an individual mouse's genes, and their tumor microenvironment,» says Jian - Hua Mao of Berkeley Lab's Life Sciences Division.
Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?
Zhang, the Nancy Dee Professor of Cancer Research, has published the breakthrough, «Microenvironment - induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth,» this month in Nature.
How exactly these genetic loci affect the tumor microenvironment and cancer development is not yet entirely understood.
A breast cancer tumor imaged with a technique that highlights aspects of its microenvironment.
The researchers expanded the relevance of these findings to lung carcinoma, showing that soluble antibodies are generally important in the tumor microenvironment to induce accumulation of MDSCs and promote cancer progression.
The Cancer Research Institute (CRI) iAtlas (www.cri-iatlas.org) is an interactive web - based platform and set of analytic tools for studying interactions between tumors and the immune microenvironment.
We are unraveling the mechanisms of this modulation in different solid and hematological malignancies and investigating ways to potentiate iNKT cell control of the tumor microenvironment for cancer immunotherapy.