Sentences with phrase «cancer stem cell markers»

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity.

Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

Not exact matches

Scientists from the German Cancer Research Center (DKFZ) have developed a way to equip mouse blood stem cells with a fluorescent marker that can be switched on from the outside.

Comparing the markers on these stem cells with those on the surfaces of cancer cells, Johnson adds, will also help scientists determine if stem cells contribute to prostate malignancies.

Significantly, cells with reduced mtDNA became self - renewing and expressed specific cell surface markers characteristic of breast cancer stem cells.

A section of a head and neck tumor — red and green markers show the proliferation of cancer stem cells — that formed when one of several newly characterized genes, Myh9, was suppressed.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

A lot of effort in tumor stem cell research has always been directed to finding a so - called marker, a molecule whose presence on a cell reliably identifies it as a cancer stem cell.

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

Although triple negative cancer cells lack the three critical genetic markers that are currently used to guide breast cancer treatment, the scientists» analysis suggests a strong reliance on signaling through pathways similar to those that affect fetal breast stem cell growth.

Stem cell marker aldehyde dehydrogenase 1 - positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression

Other flow cytometry applications include: cellular phenotyping by multiparameter cytofluorimetric analysis, sorting of fluorescence protein - tagged cells, assessing apoptosis and cell cycle status, the identification / isolation of stem and cancer stem cells (e.g., marker positive, side - population, etc.) and the deposition of single cells.

She plans to test whether or not molecules designed to target the marker can block the signaling necessary for maintaining the cells» stem - like properties, which could lead to new antibody - based immunotherapies for breast cancer.

The fact that all three markers are expressed in essentially all cells in the holoclones suggests that these three molecules are probably expressed in both cancer stem and progenitor cells.

Even more profound was a drop in insulinlike growth factor 1 (IGF - 1), which is a biomarker for cancer growth, and an increase in stem cell production, which is a marker for regeneration of cells.