Sentences with phrase «cancer tumorigenesis»

Using a comprehensive integration of genomic and molecular approaches we will determine the biochemical context in which AR signaling drives breast cancer tumorigenesis.

Not exact matches

«This novel technique,» they said, «should help distinguish and monitor cancer stages and progression, aid in elucidation of basic mechanisms underlying tumorigenesis, and facilitate analyses of processes related to early detection of cancer, screening and / or cancer risk assessment.»

«We found that AIM2 inhibits tumorigenesis in multiple animal models of colorectal cancer by restricting the pro-survival signaling molecule, Akt, which is commonly hyperactive in many human cancers.»

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

IBD is known to promote colon tumorigenesis and gave rise to the term «colitis - associated cancer.»

Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis and leads to the progressive disappearance of the oncogene expressing cells.

Identification and functional validation of proteins involved in tumorigenesis are essential steps toward advancing cancer precision medicine.

Since proliferation is a hallmark of cancer cells, the researchers analyzed the involvement of tRNA halves in tumorigenesis.

We have found that the initiation of pancreatic cancer does not follow the classic paradigm seen in colon cancer where loss of a tumor suppressor gene initiates tumorigenesis and then acquisition of an oncogene promotes tumor formation.

The tumorigenesis mechanisms of colorectal cancer have been widely studied at a molecular level.

GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.

Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis.

These findings reinforce many things that we already know: that mutations acquire gradually with age, that most of the mutations in AML (and likely other tumors) are random background events not contributing to tumorigenesis, and that subsequent mutation and evolution can give rise to subclones that ultimately determine cancer progression and response to therapy.

Cancer studies have increasingly focused on chromatin — the intertwined proteins and DNA that are packaged into chromosomes — because of its ability to regulate genes important for either activating or inhibiting tumorigenesis.

Dr. Harris is a renowned expert on the role of COX - 2 in chronic inflammation and in promoting tumorigenesis and angiogenesis, and has authored numerous papers in peer - reviewed journals and book chapters on the use of NSAIDS and selective COX - 2 inhibitors in the chemoprevention of various cancer types.

With the help of cancer biologists, these data will be leveraged to better understand the genes, proteins, and pathways underlying tumorigenesis.

Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells

Bench and mouse studies have shown that the Notch1 gene is a crucial contributor to tumorigenesis in non — small - cell lung cancer (NSCLC).

Although driver mutations were the main focus of cancer research for a long time, passenger mutational signatures, the imprints of DNA damage and DNA repair processes that have been operative during tumorigenesis, are also biologically illuminating.

In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2).

Interestingly, BRCA1 is not a haploid - insufficient tumor suppressor gene; therefore monoallelic deletion may not affect its function or affect tumorigenesis of those breast cancers bearing deletions.

The paper, Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis, http://cancerres.aacrjournals.org/content/76/8/2115, April 2016 found that colorectal cancers associated with B. fragilis could be suppressed, not just by eradicating the microorganism, BUT ALSO BY REDUCING INFLAMMATION.

Evidence exists that chronically elevated blood glucose, insulin and IGF1 levels facilitate tumorigenesis and worsen the outcome in cancer patients.