Sentences with phrase «cancers affecting the cells»

In fact, preliminary evidence already exists that HHV - 6 may be associated with some lymphomas, a diverse set of cancers affecting the cells of the immune system.

Not exact matches

And to affect more people, the cell therapies would need to go beyond blood cancers.

Importantly, HAMLET kills only cancer cells and does not affect healthy cells.

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» GreeneCancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greenecancer cell lines,» Greene said.

He identified gene mutations in breast cancer cells that affect their ability to recognize viruses, including some mutations that would be expected to significantly increase the cells» vulnerability to viruses implicated in breast cancer.

Each of the four compounds was then tested in the lab to see how it would affect a line of prostate cancer cells relatively sensitive to the chemotherapeutic Paclitaxel, commonly used to treat prostate cancer patients.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

The researchers also affected mouse models with Mantle Cell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall surviCell Lymphoma, using the new platform to target cancer cells, induce cell death and dramatically improve overall survicell death and dramatically improve overall survival.

In their latest study, they tested compounds against cells from nine different types of human cancer, including common types affecting blood, colon, breast, prostate, ovaries, kidneys, and lungs.

Although researchers do not yet know the biological significance of these discoveries, they say that fully cataloguing the genome may help them understand how genetic variations affect the risk of contracting diseases such as cancer as well as how humans grow from a single - celled embryo into an adult.

«With this discovery in our hands, we'd now like to try to find out which additional immune - cell properties cancer cells have and study how they affect the metastatic process,» says Dr Fuxe.

Multiple myeloma is a cancer that affects plasma cells.

The researchers isolated bacteria from the tumors of pancreatic cancer patients and tested how they affect the sensitivity of pancreatic cancer cells to gemcitabine, a chemotherapy drug.

Chemotherapy drugs kill cancer cells, but they also affect the vasculature inside the tumor.

Lymphoma is a type of blood cancer that affects the white blood cells — called lymphocytes — that help protect the body from infection.

Classified as either Hodgkin lymphoma or non-Hodgkin lymphoma, depending on which cells are affected, lymphoma accounted for approximately five percent of all new cancers diagnosed in the United States in 2014, according to the National Cancer Institute.

Center for Nuclear Receptors & Cell Signaling (CNRCS) Assistant Professor Daniel Frigo and his research team recently published a study investigating the processes through which androgen receptors affect prostate cancer progression.

This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

If a given drug cocktail kills 90 percent of the cancer cells but doesn't affect the remaining 10 percent, the resistant tumor cells can take over and cause the tumor to grow back.

«In a large number of diseases, ranging from cancer to ALS, major stress occurs in the affected cells, leading the UPR pathway to be triggered,» he said.

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Publishing in Nature, the study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Publishing in Nature, a recent study reports that genetic alterations affecting a part of the PD - L1 gene increases the production of the protein, allowing cancer cells to escape detection by the immune system.

Lymphoma is a cancer that affects lymphocytes, a type of white blood cell.

Organic synthesis is a scientific discipline central to the drug discovery process that is focused on building new carbon - based molecules that can affect biology — for example, targeting and destroying cancer cells.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

Published in the March 31 advance online issue of Cell, their findings reveal that circular RNAs — like their protein counterparts — are also affected by genomic rearrangements in cancer, resulting in abnormal fusions.

A wide variety of conditions that affect human adults, with the notable exception of cancer and infections, could be aided if we could stimulate regeneration, argues Mark T. Keating, a professor of cell biology at Harvard Medical School.

Researchers at Boston Children's Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

A few years ago, Manalis and colleagues set out to adapt this technique to predict how cancer drugs affect tumor cell growth.

Cancer cells, for instance, are known to be softer than normal, while asthma - affected cells can be rather stiff.

Researchers at MIT have now shown that they can use a new type of measurement to predict how drugs will affect cancer cells taken from multiple - myeloma patients.

Non-Hodgkin lymphomas are cancers that affect white blood cells of the immune system called B - lymphocytes or B cells.

I'm studying how changes in chromosome number (a condition known as aneuploidy) affect cell physiology and cancer progression.

In one experiment, the researchers created arrays of mammary epithelial cells and asked how adding one or more cells expressing low levels of the cancer gene RasG12V affected the cells around them.

Researchers have long thought that's because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death.

The researchers also tested how the loss of HSF1 affected mouse cells carrying either of two cancer - inducing mutant genes.

Samples of tumours from bowel cancer patients given different doses of resveratrol showed that even lower doses can get into cancer cells and potentially affect processes involved in tumour growth.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

With this type of cancer, the genes in the white blood cells affected change slightly, causing two chromosomes to cross.

In the 1990s the U.S. Food and Drug Administration approved its use in the treatment of both multiple myeloma (a form of cancer that affects plasma cells) and the complications of leprosy.

Affecting about one breast cancer patient in four, it is characterized by tumor cells overexpressing a signaling protein called HER2.

«New research helps explain why a deadly blood cancer often affects children with malaria: Immune responses to malaria - infected red blood cells appear to sometimes lead to cancer - promoting changes.»

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

«A better understanding of how inflammation affects stem cells and other components of tissue will revolutionize our understanding of many diseases, including cancer, and likely lead to novel therapies,» Naik says.

Merkel cell carcinoma is a rare type of skin cancer, affecting only a few thousand people each year, compared to tens of thousands with melanoma.