Sentences with phrase «candidate drugs designed»
Over the past 5 years, a few promising candidate drugs designed to ward off the effects of radiation exposure have begun to undergo animal, and even human, testing.
http://www.sciencemag.org/ Not exact matches
In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.
Many of the candidate drugs developed in recent years were designed to clear these protein aggregates.
Across many drug candidates, the team saw a several-fold increase in protein production using the new designs.
The drug candidates it has developed are designed for single pathogens, not multiple threats.
«On the other hand the US Food and Drug Administration has taken the more conservative approach which recognises that SQUIRE was designed for all - comers without prior selection, and this subgroup analysis is insufficient evidence to conclude that patients with EGFR negative tumours are not candidates.»
«Now, because we know the resistance mechanism, we can design elements to minimize the emergence of resistance as these promising new drug candidates are developed,» said Ben Shen, a TSRI professor who led the study, which was published February 20, 2014 online ahead of print by the Cell Press journal Chemistry & Biology.
«This is the first example of taking a genetic sequence and designing a drug candidate that works effectively in an animal model against triple negative breast cancer,» said TSRI Professor Matthew Disney.
In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers — triple negative breast cancer.
With its novel technology to enable mRNA as a drug, Moderna is building a fully scaled drug discovery and development platform centered on the rapid and low - cost design, delivery and production of mRNA drug candidates.
«Working closely alongside the drug development teams at Merck offers an outstanding opportunity to create new benchmarks for the R&D process, with the ultimate goal of optimizing drug candidates earlier by testing them in Organ - Chips that mirror what happens in the patients whom the medicines are designed to treat and cure,» said Geraldine A. Hamilton, Ph.D., President and Chief Scientific Officer of Emulate.
Quantitative proteomics can also be applied to identify major candidates of proteins targets and mechanism of action by specifically designed experiments using multiple drug / compounds in addition to that / those of interest and probing drug / compound - specific proteome responses to a treatment.
A series of six cell culture assays was designed to mimic multiple old - age - associated pathways of central nervous system (CNS) nerve cell damage, and drug candidates were required to show efficacy in all of these assays before being moved forward into animals.
Once utility of Foldit for fragment - based drug design is proven, candidate receptors for new puzzles will be identified in collaboration with Eli Lilly.
An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.
The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.
Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost - effective decision making in exploratory development and increase phase II success.
Combined with our structures, the screening data is enabling us to identify potential chemical selectivity cues that can be used for structure - guided design of selective anti-parasitic drug candidates.
Emulate will provide its technology along with the scientific expertise to implement a range of experimental designs for evaluating Roche's drug candidates.
Avalanche has two drug candidates designed to treat the most common forms of color vision deficiency: AVA - 322 carries the gene for L - opsin and targets protan defects and AVA - 323 carries the gene for M - opsin and targets deutan defects.
Its drug candidates are designed to improve the pharmacokinetics, pharmacodynamics, half - life, bioavailability, metabolism or distribution of drugs and improve the overall benefits and use of a drug for the patient.
It features ready - to - use packages, designed to industry best practices, to accelerate your candidate background checking and drug testing processes.