To complement ongoing positional cloning efforts, we have undertaken a large - scale
candidate gene association study.
Not exact matches
The Republican
candidate,
Gene DeFrancis, is a United States Navy veteran who founded a merchants
association.
In 2013, Soderling's group selected one of those
gene candidates, Arp2 / 3, based on its importance in controlling the formation of synapses — the links between neurons — and its
association with multiple neuropsychiatric disorders.
«These findings suggest that focusing on
genes with conserved expression levels among primates may be helpful in identifying promising
candidates for disease -
association studies,» the researchers write.
Previous genetic studies have examined the
association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of
candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of
gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.
Candidate gene and genome - wide
association studies have identified variants associated with HBV - related disease progression or hepatocellular carcinoma in various populations [46][52].
Among differentially expressed obesity and T2D
candidate genes (Supplementary Tables 4 and 5), there were significant
associations between methylation and expression for 65 sites corresponding to 17
genes (Supplementary Table 20).
Despite type 2 diabetes having been well studied by genome - wide
association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel
candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.
Projects restricted to the creation of conventional mouse knockouts in
candidate disease
genes identified by
association studies, or to broadly overexpress those
genes, are discouraged.
«We started with
candidate gene studies, then moved to common variants and genome wide
association studies, and then, most recently, leveraged exome sequencing, he said.
Candidate genes and genetic architecture revealed by whole - genome, sequence - based
association genetics in Medicago truncatula.
This section invites manuscripts describing (a) Linkage,
association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of
candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and
gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in
genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.
We examined 152 SNPs in 71
candidate genes for
association with diabetes status and related phenotypes in 2,134 Caucasians in a case - control study and an independent quantitative trait (QT) cohort in the United Kingdom.
To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD
candidate single nucleotide polymorphisms (SNPs) in seven
genes were tested for
association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the
genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).
Methods: Genetic
associations of 175 high quality polymorphisms within several malaria
candidate genes were examined in a sample of 8,096 individuals from northeast Tanzania using altitude, seroconversion rates and parasite rates as proxies of historical, recent and current malaria transmission intensity.
Due to extensive linkage disequilibrium and multiple polymorphic
candidate genes in the HLA complex, identifying the alleles responsible for these
associations has proven difficult.
299/4: 30 Large - scale exome chip
association analysis identifies novel type 2 diabetes susceptibility loci and highlights
candidate effector
genes.
330/11: 15 Colocalization of eQTLs at WHRadjBMI GWAS loci with multiple
association signals highlighted
candidate functional
genes for body fat distribution.
These include: a) Global Clusters that consist of a small, tight subset of
genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of
gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clust
gene expression profiles during successive days of standard ES cell differentiation; c) Specific
Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clust
Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of
genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of
genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the
association of
candidate genes with various FunGenES database clusters.
By integrating promoter capture Hi - C data with genetic
associations for five autoimmune diseases, we prioritised 245
candidate genes with a median distance from peak signal to prioritised
gene of 153 kb.
Studies have been extended by investigating
associations with other
candidate genes.
Genetic research comprises formal genetic studies,
candidate gene studies, linkage analyses, and recently large - scale genome wide
association studies,
gene - environement interaction studies, and pharmacogenetics.
Family - based
association study of serotonergic
candidate genes and attention - deficit / hyperactivity disorder in a German sample
The results of the present study suggest that the debate about the validity of cG × E (Duncan and Keller, 2011) and the preferred strategy of genome - wide
association studies, rather than studies of
candidate genes, merits nuance, as these designs are complementary.