Sentences with phrase «candidate gene regions»

What I like about this study is that it studied GWAS and candidate gene regions in careful investigations that included functional validation components.

Not exact matches

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

After gene mapping we had several candidate regions to choose but exome sequencing quickly identified the actual mutation.

The race was on, with the two teams probing for candidate genes in that region to determine which bore the APECED mutations.

However, further investigation revealed two candidate genomic regions that appeared to be involved, one of which contained the TGBF3 gene.

However, more studies are needed to dissect the role of the candidate regions and genes identified in selection regions,» says Järvelä.

They found that the associated regions contained numerous candidate genes, among them genes known to affect ear function, language development, memory, bird song and the brain's reward mechanism.

Another candidate gene in this region is LIM domain only 3 (LMO3 [NCBI Entrez Gene 55885), a known oncogene located about 686 kb upstream from rs2965667 (eFigure 3 in the Supplemegene in this region is LIM domain only 3 (LMO3 [NCBI Entrez Gene 55885), a known oncogene located about 686 kb upstream from rs2965667 (eFigure 3 in the SupplemeGene 55885), a known oncogene located about 686 kb upstream from rs2965667 (eFigure 3 in the Supplement).

In their search for a culprit gene, the researchers localized the gene to a small region of the genome, and then sequenced six candidate genes, based on their roles in early brain development.

The availability of an annotated rabbit genome provides a good opportunity to access candidate genes within differentiated regions.

She is scanning the genomes of individuals in the current study to identify regions that may contain additional gene candidates.

Remarkably, 30 regions were each found to contain a single gene, facilitating the identification of candidate genes underlying reproductive isolation.

For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.

Published candidate ivermectin SOR genes were largely absent in these regions; QTLs differentiating GR and SOR worms were enriched for genes in molecular pathways associated with neurotransmission, development, and stress responses.

Linking such regulatory regions to gene promoters in disease - relevant cell contexts facilitates identification of candidate disease genes.

Other than IGF1, all the other regions will require fine - mapping in order to confirm a single candidate gene.

Everts (2000) suggested a major gene model for fragmented coronoid process, which is one form of a growth disorder in the elbow joint, but approximately 80 % of the dog genome was excluded as a candidate region in a search of markers, under a hypothesis of a recessive inheritance.

Genomic regions known to harbor CMS candidate genes were screened for case allele frequencies of 1.0 and control allele frequencies of between 0.14 and 0.50.

Analysis of polymorphic microsatellites showed that the regions flanking COLQ are IBD, whereas those flanking the other 2 identified candidate genes are not.

In the absence of a population suitable for GWAS, we utilized genome - wide SNP profiles from a nuclear family to evaluate inheritance patterns in chromosomal regions harboring all 18 candidate genes.

Allele frequencies in regions on the 13 chromosomes harboring candidate genes were evaluated for a pattern consistent with a recessive trait (Table S2).

A candidate gene study of the androgen receptor gene enabled the detection of three alleles in the trinucleotide (CAG) repeat region in exon 1 in the Japanese Akita inu breed [100].