Sentences with phrase «candidate gene sequencing»

Umarova, A., Garcia, A., and Linder C. Finding the gene for repro29 infertile mice: Zcchc8 candidate gene sequencing.

Not exact matches

After gene mapping we had several candidate regions to choose but exome sequencing quickly identified the actual mutation.

Professor Lijuan Qiu and Dr Rongxia Guan at the Institute of Crop Sciences pinpointed a candidate salt tolerance gene after examining the genetic sequence of several hundred soybean varieties.

«We're generating so much sequence data right now, from so many species, that it's relatively straightforward to look for signatures of selection in genes and to find good candidates for adaptations,» Montooth said.

An analysis of whole - genome sequences from more than 5,000 people has unearthed 18 new candidate genes for autism.

Now, geneticist Bing Su of the Kunming Institute of Zoology in China and colleagues believe they have found another candidate by comparing the evolution of gene sequences across a menagerie of animals.

«There has to be a functional way of assessing the role of these cancer - gene candidates as they appear in sequencing studies,» Sanchez - Rivera says.

We helped with the analysis of targeted 3730 sequencing of some candidate genes in a warfarin patient cohort, and uncovered another gene, (CALU, encoding calumenin) in which variants influenced warfarin dose.

We also sequenced the bsl1 - 2 genome to 30 × coverage to determine whether SNPs resided in or around these candidate genes (Supplemental Data Set 1).

In the sequencing of five candidate genes (LPL, LCAT, ABCA1, PON1, and SERPINE1), rare and common SNPs were identified that were associated with differences in serum lipids.

A shotgun genome sequencing project was undertaken in the expectation that access to the complete protein coding repertoire of the organism will facilitate the search for vaccine candidate genes.

In addition to finding vaccine candidates, «the most striking feature of N. meningitidis from a genome perspective is that there are more contingency genes than any other bacterium or organism studied so far,» says Hervé Tettelin, leader of the N. meningitidis sequencing project at TIGR.

In their search for a culprit gene, the researchers localized the gene to a small region of the genome, and then sequenced six candidate genes, based on their roles in early brain development.

By sequencing the exomes of multiple individuals, isolating what we'd call «tier 1» variants — Nonsynonymous, nonsense, splice site, or frameshift - indel — and then removing all known common variants from public databases, Dr. Shendure and colleagues can reduce 20,000 gene candidates down to a handful.

«We started with candidate gene studies, then moved to common variants and genome wide association studies, and then, most recently, leveraged exome sequencing, he said.

Candidate genes and genetic architecture revealed by whole - genome, sequence - based association genetics in Medicago truncatula.

No doubt we'll be revisiting lung cancer, for which we sequenced candidate genes as part of the Tumor Sequencing Project (TSP) consortium.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

This method is designed to discover gene function and validate candidate genomic sequences involved in human disease.

Supplemental Material for «Overcoming challenges in variant calling: exploring sequence diversity in candidate genes for plant development in perennial ryegrass (Lolium perenne)»

The data indicate that the epigenetic response to maternal care involves not only single candidate gene promoters but includes transcriptional and intragenic sequences, as well as those residing distantly from transcription start sites.