Sentences with phrase «candidate genes for»

Chase et al. [106] nominated drd1 and igf1 as positional candidate genes for boldness.

This study is designed to determine the incidence of BCSL in the breed, to determine the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.

Her research initially focused on the identification and characterization of juvenile dilated cardiomyopathy in Portuguese water dogs and has led to several ongoing studies, including most recently the evaluation of various candidate genes for use in a therapeutic gene transfer approach to improve cardiac function in failing hearts.

Supplemental Material for «Overcoming challenges in variant calling: exploring sequence diversity in candidate genes for plant development in perennial ryegrass (Lolium perenne)»

Currently, the information in BGEM is used to select candidate genes for use in constructing BAC transgenic mice as part of the Gene Expression Nervous System Atlas (GENSAT) project (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gensat and http://www.gensat.org).

We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case - control study and an independent quantitative trait (QT) cohort in the United Kingdom.

This observation and the availability of a reference rabbit genome allowed us to identify several candidate genes for reproductive isolation in this system that suggest an important role for epigenetic and transcription regulation in the maintenance of reproductive barriers.

PRDM14 and DAZL could be among the candidate genes for detecting germ cells differentiated from ES cells, but both genes were expressed in ES cells to a greater degree than VASA.

This resource provided cross-species candidate genes for mammalian phenotypes, including human diseases, and stimulated interactions between basic scientists working on various organisms and the medical genetics community.

During these years, my team discovered several promising candidate genes for schizophrenia and smoking addiction.

Richarda Voer and colleagues report a study on novel candidate genes for colorectal cancer (CRC) at an early age in life.

This observation suggests that the bulk of genes involved in Nasonia immune response remain uncharacterized, with the current study being the first identification of additional candidate genes for immunity based on functional response to infection.

Moreover, 127 sites representing 65 candidate genes for obesity were differentially methylated in case - control cohort 2 (q < 0.15, P = 0.5, χ2 test; Supplementary Table 15).

We also examined whether candidate genes for T2D and / or obesity, previously identified by GWAS (P < 1.0 × 10 − 5 [www.genome.gov/gwastudies]-RRB-, exhibit differential methylation in adipose tissue of unrelated patients with diabetes versus nondiabetic subjects.

Of these, SLC24A4 and CACNA1H are potential candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers.

Several candidate genes for obesity and T2D (e.g., IRS1 and VEGFA) were differentially expressed in discordant twins.

This study presents several candidate genes for further studies of the regeneration process.

«Given that there are hundreds of candidate genes for male infertility,» Wang said, «1 percent is actually very significant.»

An analysis of whole - genome sequences from more than 5,000 people has unearthed 18 new candidate genes for autism.

Harris cited other examples of concern — a review of 100 studies in the field of psychology in which the findings in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical candidate genes for schizophrenia which found no evidence that the candidate genes are more associated with the disease than other genes.

Family - based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four.

«IL - 33 stands as one of the strongest candidate genes for asthma to date,» Barnes says.

«Humans also suffer from different types of inherited chondrodysplasia, and the ITGA10 gene could represent a good candidate gene for some of these disorders, which still have an unknown genetic cause,» tells Kaisa Kyöstilä, the first author of the paper.

In previous studies, Hu and her group reported that RORA is a novel candidate gene for autism and is regulated in opposite directions by male and female hormones.

Gomez, S., Estrada, E. and Linder, C, Zcchc8: A candidate gene for repro29 male infertility.

Evaluation of Zcchc8 as a candidate gene for male infertility in repro29 mice.

Yee, OL, Bentson, LF, Linder, CC Clip1 as a candidate gene for repro29 male infertility mice.

Despite type 2 diabetes having been well studied by genome - wide association studies in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism.

Among the early germ cell markers examined, VASA is a candidate gene for detecting pre-meiotic germ cell differentiation from monkey ES cells, because its expression is detected earlier in the primordial stage of germ cell development in comparison to that of PIWI family genes in vivo in mice and humans [11], [36]--[38], [49].

You can send it to us via our Facebook page or through the contact form... Continue reading Research Roundup: candidate gene for bad breath found, using mouse stem cells to grow hairy skin and more.

Analysis of a candidate gene for pancreatic acinar atrophy in the German Shepherd Dog.

The data will also have translational value through the discovery of a new candidate gene for GCKD in people.

She is journal published («Collie Eye Anomaly in Australian Shepherd Dogs» Rubin, Nelson and Sharp, Progress In Veterinary & Comparative Ophthalmology, 1991, 1 (2): 105 - 8 and «KITLG maps to canine chromosome 15 and is excluded as a candidate gene for merle in dogs,» Schmutz, Berryere and Sharp, Animal Genetics, 2003 Feb; 34 (1): 75 - 6.)

Not exact matches

Abeona Therapeutics (ABEO)- Data for ABO - 102 in MPS IIIA appears encouraging to me (decreases in heparan sulfate, neurocognitive benefits), initial data for ABO - 101 in MPS IIIB showed early promise, EB - 101 in RDEB could see an expedited path to market if the pivotal study yields fruit, and other gene therapy candidates are soon to enter the clinic.

Republican Gene Conway, left, and Democrat Toby Shelley are the candidates in the race for Onondaga County Sheriff.

Political Independent Gene DeFrancis Readies GOP Bid for State Assembly New York Assembly candidate (8oth AD) Gene DeFrancis became the official nominee of the Republican Party of Bronx County back February 13, 2018.

«It says something about the Labour gene pool that all the serious candidates for the leadership are white Oxbridge - educated men in their forties who were special advisers in 1997.

So Beller's team looked for just such a cluster of genes among the candidate genes in the toluenemaking sewage sample, and they found the GRE phenylacetate decarboxylase (PhdB) and its activator, PhdA.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

The postdocs refused: they were busy hunting for genes underlying Alzheimer's, and APOE seemed an unlikely candidate.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

After demonstrating the existence of several genes that control indefinite cell division, she, a grad student named Yi Ning, and their colleagues found a candidate for one of those genes on chromosome 4.

The race was on, with the two teams probing for candidate genes in that region to determine which bore the APECED mutations.

«Perhaps as many as 30 percent of schizophrenic patients may now become candidates for more precise treatment based on the individual characteristics of these four genes, with the remaining cases becoming less mysterious as we pull these groups out of the mix,» says Malaspina, the Anita Steckler and Joseph Steckler Professor in the Department of Psychiatry at NYU Langone.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

Two years ago the pharmaceutical giant GlaxoSmithKline purchased Sirtris for $ 720 million, and by August of last year The New York Times was speculating that compounds capable of activating sirtuin genes were now the leading candidates for what the newspaper called «the ultimate free lunch... a drug that tricks the body into thinking it is on [a calorie - restricted] diet.»

Matthew Brown, a skeletal geneticist at the University of Oxford says the gene is «a really hot candidate for [human] chondrocalcinosis,» a rare genetic form of joint stiffening that leads to crystal deposition and shows a similarly imbalanced pyrophosphate distribution in the joints.

Using previous data, Orkin and his team identified the BCL11A gene as a candidate for controlling the molecular switch.

Furthermore, the cells offer a renewable, long - lasting model system for testing drug candidates or gene modifications that may offer new treatments, personalized to individual patients.

We have some gene candidates for the next step of the pathway, and we are just starting to characterize those.»