Serotonergic receptor genes have been considered
candidate genes in many studies looking at panic disorders in humans, but results have been inconsistent.
We have already screened several
candidate genes in Old English Sheepdogs with PRA and also screened gene loci which cause PRA in other breeds.
This study additionally demonstrates that the systematic examination of panels of biological
candidate genes in large, well - characterised populations can be an effective complement to positional cloning approaches.
Due to extensive linkage disequilibrium and multiple polymorphic
candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult.
Such sharing raises the odds that two or more similar patients with
candidate genes in common may be found, thereby allowing their condition to be more readily studied and understood.
To demonstrate VarScan's capabilities, we used data from a collaboration with Stephen Daiger and colleagues, who are resequencing
candidate genes in a cohort of families with Retinitis Pigmentosa (RP).
They identified 10
candidate genes in the hypothalamus, an area of the brain which helps regulate anxiety.
We helped with the analysis of targeted 3730 sequencing of
some candidate genes in a warfarin patient cohort, and uncovered another gene, (CALU, encoding calumenin) in which variants influenced warfarin dose.
RESEARCH DESIGN AND METHODS Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5 ′ from five
candidate genes in umbilical cord tissue DNA from healthy neonates.
Susanne Foitzik, an evolutionary biologist at Johannes Gutenberg University Mainz in Germany who was not involved in the new research, has discovered a few
candidate genes in another slavemaking group of ants — the Myrmicinae subfamily.
The race was on, with the two teams probing for
candidate genes in that region to determine which bore the APECED mutations.
So Beller's team looked for just such a cluster of genes among
the candidate genes in the toluenemaking sewage sample, and they found the GRE phenylacetate decarboxylase (PhdB) and its activator, PhdA.
And since a medical condition with an apparent patient population of one could hardly garner federal funding, Rienhoff recast himself as a citizen scientist, a do - it - yourselfer who now finally has
a candidate gene in hand.
Cd14 is involved in the detection of bacterial factors and has been identified as
a candidate gene in genetic screens.
Another candidate gene in this region is LIM domain only 3 (LMO3 [NCBI Entrez Gene 55885), a known oncogene located about 686 kb upstream from rs2965667 (eFigure 3 in the Supplement).
For
the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.
Over the past ten years, at least 27 studies in humans, and many in other animals, have identified one
candidate gene in particular, known as NR3C1, which appears to be linked to methylation - induced changes in response to early life adversity and parental stress.
Not exact matches
Abeona Therapeutics (ABEO)- Data for ABO - 102
in MPS IIIA appears encouraging to me (decreases
in heparan sulfate, neurocognitive benefits), initial data for ABO - 101
in MPS IIIB showed early promise, EB - 101
in RDEB could see an expedited path to market if the pivotal study yields fruit, and other
gene therapy
candidates are soon to enter the clinic.
Candidates in the running include Liberal MLA Laurie Blakeman and Tory MLA's
Gene Zwozdesky, Wayne Cao, and Mary Anne Jablonski.
We identify key
candidate genes that may control rate - limiting steps during lactation and outline future work
in the endeavor to discover the biological underpinnings of poor lactation performance
in women attempting to breastfeed.
Republican
Gene Conway, left, and Democrat Toby Shelley are the
candidates in the race for Onondaga County Sheriff.
Gene DeFrancis, a registered independent, is the GOP
candidate running
in the 80th AD.
«It says something about the Labour
gene pool that all the serious
candidates for the leadership are white Oxbridge - educated men
in their forties who were special advisers
in 1997.
To generate a rich source of potential vaccine and drug target
candidates, the team identified a set of
genes that are more active
in certain stages of the parasite life cycle and within the parasite's gut.
McCallion's strategy to make sense of all this data looks at the active
genes in cells affected by a disease, groups of
genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand
gene candidates for disease risk down to just a handful within any one implicated region.
«Identifying which of these
candidate genes actually causes variation
in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur
in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics
in the Division of Biology at Kansas State University and senior author of the study.
«Within these genomes, the areas where we see relatively common Neanderthal introgression are
in genes related to metabolism and immune system responses,» says Recep Ozgur Taskent, the study's first author and a UB PhD
candidate in biological sciences.
«Essentially, we are using the human placenta as a model to identify
genes that play a key role
in invasion
in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D.
candidate leading the project,
in an email.
Predisposition to vascular disease was my focus here, using genetic epidemiological studies to identify novel polymorphisms
in a range of
candidate genes.
Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1
gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant
candidate, a single amino acid switch from alanine to threonine, as a
candidate marker for prediction.
«Perhaps as many as 30 percent of schizophrenic patients may now become
candidates for more precise treatment based on the individual characteristics of these four
genes, with the remaining cases becoming less mysterious as we pull these groups out of the mix,» says Malaspina, the Anita Steckler and Joseph Steckler Professor
in the Department of Psychiatry at NYU Langone.
A team led by Margaret Pericak - Vance of Duke University, Jonathan Haines of Vanderbilt University
in Nashville, Tennessee, and Allen Roses — a former Duke researcher now
in charge of genetics research at the Glaxo Wellcome Company
in Research Triangle Park, North Carolina — scanned the DNA of members of 16 large families with a high rate of Alzheimer's, looking at 280 genetic markers that might help identify
candidate genes.
University of Illinois researchers have identified
candidate genes controlling the accumulation of phenolic compounds
in broccoli.
We plan to take the
candidate genes we identified here and use them
in a breeding program to improve the health benefits of these vegetables.
Another
candidate, AVXS - 101 (AveXis), is a
gene therapy approach to increase SMN levels, which is
in Phase I clinical trials.
Matthew Brown, a skeletal geneticist at the University of Oxford says the
gene is «a really hot
candidate for [human] chondrocalcinosis,» a rare genetic form of joint stiffening that leads to crystal deposition and shows a similarly imbalanced pyrophosphate distribution
in the joints.
The new
candidate myeloma
genes we identified
in the African - American population may have been overlooked because of the lack of diversity
in previous genomic efforts.»
«We're generating so much sequence data right now, from so many species, that it's relatively straightforward to look for signatures of selection
in genes and to find good
candidates for adaptations,» Montooth said.
Some obvious
candidates, such as the
gene for a form of collagen which is prevalent
in breast tissue, have been excluded.
Published Dec. 18, 2017
in Nature Genetics, a team led by researchers at Joint Genome Institute (JGI) and the Howard Hughes Medical Institute at the University of North Carolina at Chapel Hill (UNC) have exploited a catalog of bacterial genomes to identify and characterize
candidate genes that aid bacteria
in adapting to plant environments, specifically
genes involved
in bacterial root colonization.
Published December 18, 2017 issue
in Nature Genetics, a team led by researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, and the Howard Hughes Medical Institute at the University of North Carolina at Chapel Hill (UNC) have exploited a catalog of bacterial genomes to identify and characterize
candidate genes that aid bacteria
in adapting to plant environments, specifically
genes involved
in bacterial root colonization.
For the new study, presented last week at the Biology of Genomes meeting here, molecular biologist Marco Osterwalder of Lawrence Berkeley National Laboratory
in Berkeley, California, and colleagues harnessed a powerful new
gene - editing technique called CRISPR to figure out exactly how some of these
candidate enhancers work.
«Importantly, the team was able to identify several
genes that may be able to help us to predict outcomes
in certain circumstances or serve as good
candidates for therapeutic efforts.»
An active international research has been carried out for several years
in order to identify
candidate genes which explain the origin and development of the disease.
The study, which has identified more than 200 rare variants inherited by children, determines that
genes YWHAZ and DRP2, among others, are new
candidates in the research on autism genetic basis.
Akassoglou and her colleagues thought they had a good
candidate in the
gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death
in the brain that also switches on soon after liver injuries.
Lynch and his colleagues are now identifying
candidates for other mammoth
genes to functionally test as well as planning experiments to study mammoth proteins
in elephant cells.
Right now, the UPV / EHU researchers are
in the phase involving the validation of
candidate genes by analyzing their expression levels
in biopsies of melanoma and nevi (growths of non-malignant melanocytes).
Harris cited other examples of concern — a review of 100 studies
in the field of psychology
in which the findings
in only about a third of the studies were reproducible; an effort by scientists at Bayer, another large drug company, that managed to reproduce the findings of only one - quarter of the studies under review; a just - published review of 25 historical
candidate genes for schizophrenia which found no evidence that the
candidate genes are more associated with the disease than other
genes.
Pruitt says RNA «templates» derived from the original
gene and stored
in the gametes are the best
candidates for reverting the mutant
gene to its original state.