The race was on, with the two teams probing for
candidate genes in that region to determine which bore the APECED mutations.
Another candidate gene in this region is LIM domain only 3 (LMO3 [NCBI Entrez Gene 55885), a known oncogene located about 686 kb upstream from rs2965667 (eFigure 3 in the Supplement).
For
the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.
Not exact matches
McCallion's strategy to make sense of all this data looks at the active
genes in cells affected by a disease, groups of
genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand
gene candidates for disease risk down to just a handful within any one implicated
region.
However, more studies are needed to dissect the role of the
candidate regions and
genes identified
in selection
regions,» says Järvelä.
What I like about this study is that it studied GWAS and
candidate gene regions in careful investigations that included functional validation components.
In their search for a culprit gene, the researchers localized the gene to a small region of the genome, and then sequenced six candidate genes, based on their roles in early brain developmen
In their search for a culprit
gene, the researchers localized the
gene to a small
region of the genome, and then sequenced six
candidate genes, based on their roles
in early brain developmen
in early brain development.
She is scanning the genomes of individuals
in the current study to identify
regions that may contain additional
gene candidates.
Published
candidate ivermectin SOR
genes were largely absent
in these
regions; QTLs differentiating GR and SOR worms were enriched for
genes in molecular pathways associated with neurotransmission, development, and stress responses.
Linking such regulatory
regions to
gene promoters
in disease - relevant cell contexts facilitates identification of
candidate disease
genes.
Other than IGF1, all the other
regions will require fine - mapping
in order to confirm a single
candidate gene.
Everts (2000) suggested a major
gene model for fragmented coronoid process, which is one form of a growth disorder
in the elbow joint, but approximately 80 % of the dog genome was excluded as a
candidate region in a search of markers, under a hypothesis of a recessive inheritance.
In the absence of a population suitable for GWAS, we utilized genome - wide SNP profiles from a nuclear family to evaluate inheritance patterns in chromosomal regions harboring all 18 candidate gene
In the absence of a population suitable for GWAS, we utilized genome - wide SNP profiles from a nuclear family to evaluate inheritance patterns
in chromosomal regions harboring all 18 candidate gene
in chromosomal
regions harboring all 18
candidate genes.
Allele frequencies
in regions on the 13 chromosomes harboring
candidate genes were evaluated for a pattern consistent with a recessive trait (Table S2).
A
candidate gene study of the androgen receptor
gene enabled the detection of three alleles
in the trinucleotide (CAG) repeat
region in exon 1
in the Japanese Akita inu breed [100].