Sentences with phrase «candidate genes in the human»

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«Essentially, we are using the human placenta as a model to identify genes that play a key role in invasion in both the placenta and cancer,» wrote Chi Sutherland, a Ph.D. candidate leading the project, in an email.

Matthew Brown, a skeletal geneticist at the University of Oxford says the gene is «a really hot candidate for [human] chondrocalcinosis,» a rare genetic form of joint stiffening that leads to crystal deposition and shows a similarly imbalanced pyrophosphate distribution in the joints.

Perform phenotypic profiling in primary human cells to identify and characterize candidate genes with therapeutic potential,

His lab has extensive experience evaluating and modulating T cell responses to tumors and viruses, including introducing genes into T cells to impart specificity and modulate function, designing strategies to overcome tolerance and enhance in vivo activity, and developing mouse models that more accurately model human immune responses to candidate vaccines.

Among the early germ cell markers examined, VASA is a candidate gene for detecting pre-meiotic germ cell differentiation from monkey ES cells, because its expression is detected earlier in the primordial stage of germ cell development in comparison to that of PIWI family genes in vivo in mice and humans [11], [36]--[38], [49].

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

CXCR4, which is a chemokine receptor, is expressed in migratory and post-migratory germ cells in vivo in mice [27], and is also a marker for germ cells derived from human ES cells [28], thus suggesting that CXCR4 is a candidate marker gene for detecting ES cells - derived germ cell in monkeys.

For the candidate gene in the region, RSPO3, we demonstrated expression in key liver - resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.

This method is designed to discover gene function and validate candidate genomic sequences involved in human disease.

Although all seven genes in the interval are Idd10 candidates, we suggest the gene encoding the EWI immunoglobulin subfamily member EWI - 101 (Cd101) as the most likely Idd10 candidate because of the previously reported immune - associated properties of the human CD101 molecule.

One way they have looked for these potential «genetic modifiers,» has been through a candidate gene approach, methodically hand - picking their most likely candidates from the 20,000 - some genes in the human genome.

Candidate gene - a gene that might be relevant to a specific canine disease due to the gene's role in a similar disease in another animal or human.

The canine disease is compared to similar diseases in other species, most often humans, to determine if there are any possible candidate genes (i.e., genes that are known to be involved in these similar diseases or in the normal processes affected by the disease may offer important leads).

Serotonergic receptor genes have been considered candidate genes in many studies looking at panic disorders in humans, but results have been inconsistent.

Over the past ten years, at least 27 studies in humans, and many in other animals, have identified one candidate gene in particular, known as NR3C1, which appears to be linked to methylation - induced changes in response to early life adversity and parental stress.